Free recombination within Helicobacter pylori - PubMed (original) (raw)
Free recombination within Helicobacter pylori
S Suerbaum et al. Proc Natl Acad Sci U S A. 1998.
Abstract
Sequences of three gene fragments (flaA, flaB, and vacA) from Helicobacter pylori strains isolated from patients in Germany, Canada, and South Africa were analyzed for diversity and for linkage equilibrium by using the Homoplasy Test and compatibility matrices. Horizontal genetic exchange in H. pylori is so frequent that different loci and polymorphisms within each locus are all at linkage equilibrium. These results indicate that H. pylori is panmictic. Comparisons with sequences from Escherichia coli, Neisseria meningitidis, and Drosophila melanogaster showed that recombination in H. pylori was much more frequent than in other species. In contrast, when multiple family members infected with H. pylori were investigated, some strains were indistinguishable at all three loci. Thus, H. pylori is clonal over short time periods after natural transmission.
Figures
Figure 1
Representative compatibility matrices of alleles from different species. White spaces represent pairs of informative sites that are compatible with a maximal parsimony tree and black spaces show pairs of sites that could not be accommodated by such a tree. The genes selected from each species were broadly representative of the other genes examined and were chosen as including approximately the same number of informative sites. Quantitative mean neighborhood similarities are given in Table 2.
Similar articles
- Construction of expression systems for flaA and flaB genes of Helicobacter pylori and determination of immunoreactivity and antigenicity of recombinant proteins.
Yan J, Liang SH, Mao YF, Li LW, Li SP. Yan J, et al. World J Gastroenterol. 2003 Oct;9(10):2240-50. doi: 10.3748/wjg.v9.i10.2240. World J Gastroenterol. 2003. PMID: 14562386 Free PMC article. - Cloning and genetic characterization of a Helicobacter pylori flagellin gene.
Leying H, Suerbaum S, Geis G, Haas R. Leying H, et al. Mol Microbiol. 1992 Oct;6(19):2863-74. doi: 10.1111/j.1365-2958.1992.tb01466.x. Mol Microbiol. 1992. PMID: 1435261 - Allelic variation in the Helicobacter pylori flagellin genes flaA and flaB: its consequences for strain typing schemes and population structure.
Forbes KJ, Fang Z, Pennington TH. Forbes KJ, et al. Epidemiol Infect. 1995 Apr;114(2):257-66. doi: 10.1017/s0950268800057927. Epidemiol Infect. 1995. PMID: 7705489 Free PMC article.
Cited by
- Genetic variation and linkage disequilibrium in Bacillus anthracis.
Zwick ME, Thomason MK, Chen PE, Johnson HR, Sozhamannan S, Mateczun A, Read TD. Zwick ME, et al. Sci Rep. 2011;1:169. doi: 10.1038/srep00169. Epub 2011 Nov 24. Sci Rep. 2011. PMID: 22355684 Free PMC article. - Prophage-like gene transfer agents promote Caulobacter crescentus survival and DNA repair during stationary phase.
Gozzi K, Tran NT, Modell JW, Le TBK, Laub MT. Gozzi K, et al. PLoS Biol. 2022 Nov 3;20(11):e3001790. doi: 10.1371/journal.pbio.3001790. eCollection 2022 Nov. PLoS Biol. 2022. PMID: 36327213 Free PMC article. - Identifying strains that contribute to complex diseases through the study of microbial inheritance.
Faith JJ, Colombel JF, Gordon JI. Faith JJ, et al. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):633-40. doi: 10.1073/pnas.1418781112. Epub 2015 Jan 9. Proc Natl Acad Sci U S A. 2015. PMID: 25576328 Free PMC article. - Potential DNA binding and nuclease functions of ComEC domains characterized in silico.
Baker JA, Simkovic F, Taylor HM, Rigden DJ. Baker JA, et al. Proteins. 2016 Oct;84(10):1431-42. doi: 10.1002/prot.25088. Epub 2016 Jul 1. Proteins. 2016. PMID: 27318187 Free PMC article. - Helicobacter pylori genome variability in a framework of familial transmission.
Kivi M, Rodin S, Kupershmidt I, Lundin A, Tindberg Y, Granström M, Engstrand L. Kivi M, et al. BMC Microbiol. 2007 Jun 11;7:54. doi: 10.1186/1471-2180-7-54. BMC Microbiol. 2007. PMID: 17562007 Free PMC article.
References
- Peterson W L. N Engl J Med. 1991;324:1043–1048. - PubMed
- Parsonnet J, Friedman G D, Vandersteen D P, Chang Y, Vogelman J H, Orentreich N, Sibley R K. N Engl J Med. 1991;325:1127–1131. - PubMed
- Bayerdörffer E, Neubauer A, Rudolph B, Thiede C, Lehn N, Eidt S, Stolte M. Lancet. 1995;345:1591–1594. - PubMed
- Labigne A, de Reuse H. Infect Agents Dis. 1996;5:191–202. - PubMed
- Majewski S I, Goodwin C S. J Infect Dis. 1988;157:465–471. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources