G protein signaling events are activated at the leading edge of chemotactic cells - PubMed (original) (raw)
G protein signaling events are activated at the leading edge of chemotactic cells
C A Parent et al. Cell. 1998.
Free article
Abstract
Directional sensing by eukaryotic cells does not require polarization of chemoattractant receptors. The translocation of the PH domain-containing protein CRAC in D. discoideum to binding sites on the inner face of the plasma membrane reflects activation of the G protein-linked signaling system. Increments in chemoattractant elicit a uniform response around the cell periphery. Yet when cells are exposed to a gradient, the activation occurs selectively at the stimulated edge, even in immobilized cells. We propose that such localized activation, transmitted by the recruitment of cytosolic proteins, may be a general mechanism for gradient sensing by G protein-linked chemotactic systems including those involving chemotactic cytokines in leukocytes.
Comment in
- Follow the leader.
Meili R, Firtel RA. Meili R, et al. Dev Cell. 2003 Mar;4(3):291-3. doi: 10.1016/s1534-5807(03)00064-9. Dev Cell. 2003. PMID: 12636911 Review.
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