A CLOCK polymorphism associated with human diurnal preference - PubMed (original) (raw)

Comparative Study

. 1998 Sep 15;21(6):569-76.

doi: 10.1093/sleep/21.6.569.

Affiliations

• PMID: 9779516
• DOI: 10.1093/sleep/21.6.569

Comparative Study

A CLOCK polymorphism associated with human diurnal preference

D Katzenberg et al. Sleep. 1998.

Abstract

A single nucleotide polymorphism located in the 3' flanking region of the human CLOCK gene was investigated as a predictor of diurnal preference in a population-based random sample of 410 normal adults. Morningness-eveningness preferences were determined using the 19-item Home-Ostberg questionnaire. Subjects carrying one of the two CLOCK alleles, 3111C, had a significantly lower mean Horne-Ostberg score. The distribution of scores was clearly shifted toward eveningness for these subjects. The score difference was independent of age, sex and ethnic heritage, thus making population stratification effects unlikely to explain this difference. These subjects had a substantial 10- to 44-minute delay in preferred timing for activity or sleep episodes. We suggest that the identified polymorphism or another tightly linked polymorphism within the CLOCK gene or its regulatory elements may be responsible for the finding.

PubMed Disclaimer

Similar articles

• The 3111T/C polymorphism of hClock is associated with evening preference and delayed sleep timing in a Japanese population sample.
  Mishima K, Tozawa T, Satoh K, Saitoh H, Mishima Y. Mishima K, et al. Am J Med Genet B Neuropsychiatr Genet. 2005 Feb 5;133B(1):101-4. doi: 10.1002/ajmg.b.30110. Am J Med Genet B Neuropsychiatr Genet. 2005. PMID: 15578592
• The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects.
  Robilliard DL, Archer SN, Arendt J, Lockley SW, Hack LM, English J, Leger D, Smits MG, Williams A, Skene DJ, Von Schantz M. Robilliard DL, et al. J Sleep Res. 2002 Dec;11(4):305-12. doi: 10.1046/j.1365-2869.2002.00320.x. J Sleep Res. 2002. PMID: 12464098
• A polymorphism in the human timeless gene is not associated with diurnal preferences in normal adults.
  Pedrazzoli M, Ling L, Finn L, Kubin L, Young T, Katzenberg D, Mignot E. Pedrazzoli M, et al. Sleep Res Online. 2000;3(2):73-6. Sleep Res Online. 2000. PMID: 11382904
• Epidemiology of the human circadian clock.
  Roenneberg T, Kuehnle T, Juda M, Kantermann T, Allebrandt K, Gordijn M, Merrow M. Roenneberg T, et al. Sleep Med Rev. 2007 Dec;11(6):429-38. doi: 10.1016/j.smrv.2007.07.005. Epub 2007 Nov 1. Sleep Med Rev. 2007. PMID: 17936039 Review.
• [Biology and genetics of circadian rhythm].
  Bellivier F. Bellivier F. Encephale. 2009 Jan;35 Suppl 2:S53-7. doi: 10.1016/S0013-7006(09)75534-4. Encephale. 2009. PMID: 19268171 Review. French.

Cited by

• A Complex Relationship Among the Circadian Rhythm, Reward Circuit and Substance Use Disorder (SUD).
  Samanta S, Bagchi D, Gold MS, Badgaiyan RD, Barh D, Blum K. Samanta S, et al. Psychol Res Behav Manag. 2024 Oct 9;17:3485-3501. doi: 10.2147/PRBM.S473310. eCollection 2024. Psychol Res Behav Manag. 2024. PMID: 39411118 Free PMC article. Review.
• Association between sleep duration and the risk of hyperhomocysteinemia among adults in the United States: National Health and Nutrition Examination Survey, 2005-2006.
  Xu L, Jia Y, Xiao Q. Xu L, et al. Sleep Biol Rhythms. 2024 Jun 22;22(4):505-512. doi: 10.1007/s41105-024-00538-9. eCollection 2024 Oct. Sleep Biol Rhythms. 2024. PMID: 39300983 Free PMC article.
• Bipolar Disorder, Circadian Rhythm and Clock Genes.
  Chung J, Kim YC, Jeong JH. Chung J, et al. Clin Psychopharmacol Neurosci. 2024 May 31;22(2):211-221. doi: 10.9758/cpn.23.1093. Epub 2023 Jul 17. Clin Psychopharmacol Neurosci. 2024. PMID: 38627069 Free PMC article. Review.
• Risk for Seasonal Affective Disorder (SAD) Linked to Circadian Clock Gene Variants.
  Dang T, Russel WA, Saad T, Dhawka L, Ay A, Ingram KK. Dang T, et al. Biology (Basel). 2023 Dec 15;12(12):1532. doi: 10.3390/biology12121532. Biology (Basel). 2023. PMID: 38132358 Free PMC article.
• Machine learning analyses reveal circadian clock features predictive of anxiety among UK biobank participants.
  Ventresca C, Mohamed W, Russel WA, Ay A, Ingram KK. Ventresca C, et al. Sci Rep. 2023 Dec 15;13(1):22304. doi: 10.1038/s41598-023-49644-7. Sci Rep. 2023. PMID: 38102312 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Ovid Technologies, Inc.
  • Silverchair Information Systems

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • BioCyc