Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis - PubMed (original) (raw)
. 1998 Oct 30;273(44):28912-20.
doi: 10.1074/jbc.273.44.28912.
Affiliations
- PMID: 9786894
- DOI: 10.1074/jbc.273.44.28912
Free article
Mak21p of Saccharomyces cerevisiae, a homolog of human CAATT-binding protein, is essential for 60 S ribosomal subunit biogenesis
H K Edskes et al. J Biol Chem. 1998.
Free article
Abstract
Mak21-1 mutants are unable to propagate M1 double-stranded RNA, a satellite of the L-A double-stranded RNA virus, encoding a secreted protein toxin lethal to yeast strains that do not carry M1. We cloned MAK21 using its map location and found that Mak21p is homologous to a human and mouse CAATT-binding protein and open reading frames in Schizosaccharomyces pombe and Caenorhabditis elegans. Although the human protein regulates Hsp70 production, Mak21p is essential for growth and necessary for 60 S ribosomal subunit biogenesis. mak21-1 mutants have decreased levels of L-A coat protein and L-A double-stranded RNA. Electroporation with reporter mRNAs shows that mak21-1 cells cannot optimally express mRNAs which, like L-A viral mRNA, lack 3'-poly(A) or 5'-cap structures but can normally express mRNA with both cap and poly(A). The virus propagation phenotype of mak21-1 is suppressed by ski2 or ski6 mutations, each of which derepresses translation of non-poly(A) mRNA.
Similar articles
- Ski6p is a homolog of RNA-processing enzymes that affects translation of non-poly(A) mRNAs and 60S ribosomal subunit biogenesis.
Benard L, Carroll K, Valle RC, Wickner RB. Benard L, et al. Mol Cell Biol. 1998 May;18(5):2688-96. doi: 10.1128/MCB.18.5.2688. Mol Cell Biol. 1998. PMID: 9566888 Free PMC article. - The ski7 antiviral protein is an EF1-alpha homolog that blocks expression of non-Poly(A) mRNA in Saccharomyces cerevisiae.
Benard L, Carroll K, Valle RC, Masison DC, Wickner RB. Benard L, et al. J Virol. 1999 Apr;73(4):2893-900. doi: 10.1128/JVI.73.4.2893-2900.1999. J Virol. 1999. PMID: 10074137 Free PMC article. - Ribosomal protein L33 is required for ribosome biogenesis, subunit joining, and repression of GCN4 translation.
Martín-Marcos P, Hinnebusch AG, Tamame M. Martín-Marcos P, et al. Mol Cell Biol. 2007 Sep;27(17):5968-85. doi: 10.1128/MCB.00019-07. Epub 2007 Jun 4. Mol Cell Biol. 2007. PMID: 17548477 Free PMC article. - Molecular analysis of the dhp1+ gene of Schizosaccharomyces pombe: an essential gene that has homology to the DST2 and RAT1 genes of Saccharomyces cerevisiae.
Sugano S, Shobuike T, Takeda T, Sugino A, Ikeda H. Sugano S, et al. Mol Gen Genet. 1994 Apr;243(1):1-8. doi: 10.1007/BF00283869. Mol Gen Genet. 1994. PMID: 8190062 - Translation and M1 double-stranded RNA propagation: MAK18 = RPL41B and cycloheximide curing.
Carroll K, Wickner RB. Carroll K, et al. J Bacteriol. 1995 May;177(10):2887-91. doi: 10.1128/jb.177.10.2887-2891.1995. J Bacteriol. 1995. PMID: 7751301 Free PMC article.
Cited by
- BmC/EBPZ gene is essential for the larval growth and development of silkworm, Bombyx mori.
Mei X, Huang T, Chen A, Liu W, Jiang L, Zhong S, Shen D, Qiao P, Zhao Q. Mei X, et al. Front Physiol. 2024 Mar 7;15:1298869. doi: 10.3389/fphys.2024.1298869. eCollection 2024. Front Physiol. 2024. PMID: 38523808 Free PMC article. - Intrinsic protein disorder is insufficient to drive subnuclear clustering in embryonic transcription factors.
Hannon CE, Eisen MB. Hannon CE, et al. Elife. 2024 Jan 26;12:RP88221. doi: 10.7554/eLife.88221. Elife. 2024. PMID: 38275292 Free PMC article. - Conservation and Expansion of Transcriptional Factor Repertoire in the Fusarium oxysporum Species Complex.
Yu H, Yang H, Haridas S, Hayes RD, Lynch H, Andersen S, Newman M, Li G, Martínez-Soto D, Milo-Cochavi S, Hazal Ayhan D, Zhang Y, Grigoriev IV, Ma LJ. Yu H, et al. J Fungi (Basel). 2023 Mar 15;9(3):359. doi: 10.3390/jof9030359. J Fungi (Basel). 2023. PMID: 36983527 Free PMC article. - Conservation and Expansion of Transcriptional Factor Repertoire in the Fusarium oxysporum Species Complex.
Yu H, Yang H, Haridas S, Hayes RD, Lynch H, Andersen S, Li G, Martínez-Soto D, Milo-Cochavi S, Ayhan DH, Zhang Y, Grigoriev IV, Ma LJ. Yu H, et al. bioRxiv [Preprint]. 2023 Feb 10:2023.02.09.527873. doi: 10.1101/2023.02.09.527873. bioRxiv. 2023. PMID: 36798233 Free PMC article. Updated. Preprint. - Reduction of nucleolar NOC1 leads to the accumulation of pre-rRNAs and induces Xrp1, affecting growth and resulting in cell competition.
Destefanis F, Manara V, Santarelli S, Zola S, Brambilla M, Viola G, Maragno P, Signoria I, Viero G, Pasini ME, Penzo M, Bellosta P. Destefanis F, et al. J Cell Sci. 2022 Dec 1;135(23):jcs260110. doi: 10.1242/jcs.260110. Epub 2022 Dec 7. J Cell Sci. 2022. PMID: 36314272 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous