An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components - PubMed (original) (raw)
. 1998 Nov 6;283(4):837-62.
doi: 10.1006/jmbi.1998.2115.
Affiliations
- PMID: 9790844
- DOI: 10.1006/jmbi.1998.2115
An extracellular beta-propeller module predicted in lipoprotein and scavenger receptors, tyrosine kinases, epidermal growth factor precursor, and extracellular matrix components
T A Springer. J Mol Biol. 1998.
Abstract
An abundant, widely dispersed, extracellular sequence repeat that contains a consensus YWTD motif is shown here to occur in groups of six contiguous repeats. Thirteen lines of evidence, including experimental and computational data, predict with p<3x10(-9) that the repeats do not form tandem domains, but rather each group of six repeats folds into a compact beta-propeller structure. The six beta-sheets are arranged about a 6-fold pseudosymmetry axis, and each repeat contributes loops to the faces surrounding the pseudosymmetry axis. Seven different endocytic receptors that contain from one to eight YWTD beta-propeller domains act as lipoprotein, vitellogenin, and scavenger receptors. In the low density lipoprotein receptor (LDLR), the many mutations in familial hypercholesterolaemia that map to the YWTD domain can now be interpreted. In the extracellular matrix component nidogen, the YWTD domain functions to bind laminin. Three YWTD domains and interspersed fibronectin type III (FN3) domains constitute almost the entire extracellular domain of the sevenless and c-ros receptor tyrosine kinases. YWTD domains often are bounded by epidermal growth factor (EGF) modules, including in the EGF precursor itself. YWTD beta-propellers have a circular folding pattern that brings neighboring modules into close proximity, and may have important consequences for the architecture of multi-domain proteins.
Copyright 1998 Academic Press.
Similar articles
- Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.
Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Jeon H, et al. Nat Struct Biol. 2001 Jun;8(6):499-504. doi: 10.1038/88556. Nat Struct Biol. 2001. PMID: 11373616 - NMR structure and backbone dynamics of a concatemer of epidermal growth factor homology modules of the human low-density lipoprotein receptor.
Kurniawan ND, Aliabadizadeh K, Brereton IM, Kroon PA, Smith R. Kurniawan ND, et al. J Mol Biol. 2001 Aug 10;311(2):341-56. doi: 10.1006/jmbi.2001.4867. J Mol Biol. 2001. PMID: 11478865 - Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface.
Takagi J, Yang Y, Liu JH, Wang JH, Springer TA. Takagi J, et al. Nature. 2003 Aug 21;424(6951):969-74. doi: 10.1038/nature01873. Nature. 2003. PMID: 12931195 - The many faces of epidermal growth factor repeats.
Davis CG. Davis CG. New Biol. 1990 May;2(5):410-9. New Biol. 1990. PMID: 2288911 Review. - Sequence analysis of the non-recurring C-terminal domains shows that insect lipoprotein receptors constitute a distinct group of LDL receptor family members.
Rodenburg KW, Smolenaars MM, Van Hoof D, Van der Horst DJ. Rodenburg KW, et al. Insect Biochem Mol Biol. 2006 Apr;36(4):250-63. doi: 10.1016/j.ibmb.2006.01.003. Epub 2006 Jan 18. Insect Biochem Mol Biol. 2006. PMID: 16551539 Review.
Cited by
- Novel insight into mechanisms of ROS1 catalytic activation via loss of the extracellular domain.
Jones K, Keddy C, Jenkins C, Nicholson K, Shinde U, Davare MA. Jones K, et al. Sci Rep. 2024 Sep 27;14(1):22191. doi: 10.1038/s41598-024-71687-7. Sci Rep. 2024. PMID: 39333184 Free PMC article. - Current treatment and novel insights regarding ROS1-targeted therapy in malignant tumors.
Li S, Zhang H, Chen T, Zhang X, Shang G. Li S, et al. Cancer Med. 2024 Apr;13(8):e7201. doi: 10.1002/cam4.7201. Cancer Med. 2024. PMID: 38629293 Free PMC article. Review. - Novel LDLR variants affecting low density lipoprotein metabolism identified in familial hypercholesterolemia.
Wang M, Hong L, Cai L, Zhang Z, Jiang N, Chen Y, Ying Q, Kong L, Wei Z, Xu Y, Jin L. Wang M, et al. Mol Biol Rep. 2024 Jan 18;51(1):153. doi: 10.1007/s11033-023-09169-8. Mol Biol Rep. 2024. PMID: 38236436 - Lumicrine signaling: Extracellular regulation of sperm maturation in the male reproductive tract lumen.
Kiyozumi D. Kiyozumi D. Genes Cells. 2023 Nov;28(11):757-763. doi: 10.1111/gtc.13066. Epub 2023 Sep 11. Genes Cells. 2023. PMID: 37696504 Free PMC article. Review. - Structures of LRP2 reveal a molecular machine for endocytosis.
Beenken A, Cerutti G, Brasch J, Guo Y, Sheng Z, Erdjument-Bromage H, Aziz Z, Robbins-Juarez SY, Chavez EY, Ahlsen G, Katsamba PS, Neubert TA, Fitzpatrick AWP, Barasch J, Shapiro L. Beenken A, et al. Cell. 2023 Feb 16;186(4):821-836.e13. doi: 10.1016/j.cell.2023.01.016. Epub 2023 Feb 6. Cell. 2023. PMID: 36750096 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases