Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells - PubMed (original) (raw)
. 1998 Oct 29;251(3):802-5.
doi: 10.1006/bbrc.1998.9552.
Affiliations
- PMID: 9790990
- DOI: 10.1006/bbrc.1998.9552
Protein kinase C phosphorylates and activates GTP cyclohydrolase I in rat renal mesangial cells
C Lapize et al. Biochem Biophys Res Commun. 1998.
Abstract
GTP cyclohydrolase I is the rate-limiting enzyme in the de novo synthesis pathway of tetrahydrobiopterin which is an essential cofactor for all NO synthase isoforms. The expression of GTP cyclohydrolase I is regulated on a transcriptional level by a variety of cytokines like interleukin 1beta or tumor necrosis factor alpha. The present paper reports that stimulation of protein kinase C by angiotensin II, platelet-derived growth factor BB or the phorbol ester 12-O-tetradecanoylphorbol-13-acetate triggers the phosphorylation and activation of GTP cyclohydrolase I. These data establish that in addition to transcriptional regulation, there is a prominent post-transcriptional modulation of enzyme activity.
Copyright 1998 Academic Press.
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