PIP2 and PIP as determinants for ATP inhibition of KATP channels - PubMed (original) (raw)
PIP2 and PIP as determinants for ATP inhibition of KATP channels
T Baukrowitz et al. Science. 1998.
Abstract
Adenosine triphosphate (ATP)-sensitive potassium (KATP) channels couple electrical activity to cellular metabolism through their inhibition by intracellular ATP. ATP inhibition of KATP channels varies among tissues and is affected by the metabolic and regulatory state of individual cells, suggesting involvement of endogenous factors. It is reported here that phosphatidylinositol-4, 5-bisphosphate (PIP2) and phosphatidylinositol-4-phosphate (PIP) controlled ATP inhibition of cloned KATP channels (Kir6.2 and SUR1). These phospholipids acted on the Kir6.2 subunit and shifted ATP sensitivity by several orders of magnitude. Receptor-mediated activation of phospholipase C resulted in inhibition of KATP-mediated currents. These results represent a mechanism for control of excitability through phospholipids.
Comment in
- Exciting times for PIP2.
Ashcroft FM. Ashcroft FM. Science. 1998 Nov 6;282(5391):1059-60. doi: 10.1126/science.282.5391.1059. Science. 1998. PMID: 9841452 No abstract available.
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