Oxidized phospholipids and isoprostanes in atherosclerosis - PubMed (original) (raw)
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Oxidized phospholipids and isoprostanes in atherosclerosis
J L Witztum et al. Curr Opin Lipidol. 1998 Oct.
Abstract
Lipid oxidation has been shown to be a prominent feature of atherosclerosis. The presence of isoprostanes and other lipid oxidation products has been clearly demonstrated in lesions. Furthermore, antibodies to oxidized phospholipids have been identified in animal and human models. Recent evidence suggests that oxidized phospholipids may activate all vascular cell types. The identification and isolation of particular oxidative products has provided some important information about the receptors for these active lipids.
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