Chemical basis for alkali cation selectivity in potassium-channel proteins - PubMed (original) (raw)

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Chemical basis for alkali cation selectivity in potassium-channel proteins

E Moczydlowski. Chem Biol. 1998 Nov.

Abstract

The determination of the crystal structure of a K+-selective channel protein from Streptomyces lividans reveals how the rapid movement of K+ across membranes is catalyzed by a large family of pore-forming proteins. Many features of the structure mirror hypotheses, predictions and models of K+ channels developed over the past four decades of functional analysis.

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