Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins - PubMed (original) (raw)

. 1998 Nov;433(5):419-26.

doi: 10.1007/s004280050269.

Affiliations

• PMID: 9849856
• DOI: 10.1007/s004280050269

Helicobacter pylori infection produces reversible glycosylation changes to gastric mucins

H Ota et al. Virchows Arch. 1998 Nov.

Abstract

The protective ability of gastric mucins may depend largely on their oligosaccharide chains. We evaluated the effects of H. pylori infection on the glycosylation of gastric mucins. Gastric biopsy specimens from 20 H. pylori-infected patients before and after cure of the H. pylori infection and 8 normal uninfected volunteers were examined by immunostaining for simple mucin-type glycoproteins and blood-group-related antigens bearing type 1 chain backbone. The immunoreactivity in different gastric compartments was evaluated. Simple mucin-type glycoproteins and blood-group-related antigens were expressed in surface mucous cells. Simple mucin-type glycoproteins showed antrum-predominant expression in normal volunteers and were found in significantly fewer surface mucous cells in infected patients than in normal volunteers; their expression was restored after eradication of H. pylori. Sialyl Lewis(a) and Lewis(b) were expressed in fewer surface mucous cells after than before eradication. The patterns of glycosylation of gastric mucins vary in different gastric compartments and are reversibly altered by H. pylori infection. These alterations may affect the protective functions of gastric mucins.

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Comment in

• Simple mucin-type carbohydrate antigens in Helicobacter pylori-positive chronic active gastritis.
  Barresi G, Vitarelli E, Giuffrè G, Grosso M, Tuccari G. Barresi G, et al. Virchows Arch. 1999 Oct;435(4):458-60. doi: 10.1007/s004280050426. Virchows Arch. 1999. PMID: 10526012 No abstract available.

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