Embryonic stem cells and transgenic mice in the study of hematopoiesis - PubMed (original) (raw)

Affiliations

• PMID: 9853823

Review

Embryonic stem cells and transgenic mice in the study of hematopoiesis

S H Orkin. Int J Dev Biol. 1998.

Abstract

Blood formation (hematopoiesis) entails the generation of hematopoietic stem cells (HSCs) within the embryo and subsequent commitment of multipotential progenitors to differentiation along single lineages. These processes are controlled in large part by cell-restricted transcription factors which cooperate with more widely expressed factors to direct lineage-specific gene expression. Candidate hematopoietic transcriptional regulators have been identified by characterizing factors mediating cell-specific gene transcription and by defining genes involved in chromosomal rearrangements in leukemia. The application of transgenic and embryonic stem cell methods have provided insights into their in vivo functions and suggested mechanisms by which lineage selection may be achieved. One of the first, and best, characterized hematopoietic transcription factors is GATA-1. Herein studies of GATA-1 are reviewed to illustrate how manipulations of its locus in the mouse have contributed to current understanding in unique and unexpected ways.

PubMed Disclaimer

Similar articles

• SCL expression at critical points in human hematopoietic lineage commitment.
  Zhang Y, Payne KJ, Zhu Y, Price MA, Parrish YK, Zielinska E, Barsky LW, Crooks GM. Zhang Y, et al. Stem Cells. 2005 Jun-Jul;23(6):852-60. doi: 10.1634/stemcells.2004-0260. Stem Cells. 2005. PMID: 15917481
• Chromatin immunoselection defines a TAL-1 target gene.
  Cohen-Kaminsky S, Maouche-Chrétien L, Vitelli L, Vinit MA, Blanchard I, Yamamoto M, Peschle C, Roméo PH. Cohen-Kaminsky S, et al. EMBO J. 1998 Sep 1;17(17):5151-60. doi: 10.1093/emboj/17.17.5151. EMBO J. 1998. PMID: 9724651 Free PMC article.
• Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.
  Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH. Mikkola HK, et al. Nature. 2003 Jan 30;421(6922):547-51. doi: 10.1038/nature01345. Epub 2003 Jan 19. Nature. 2003. PMID: 12540851
• The SCL/TAL1 gene: roles in normal and malignant haematopoiesis.
  Robb L, Begley CG. Robb L, et al. Bioessays. 1997 Jul;19(7):607-13. doi: 10.1002/bies.950190711. Bioessays. 1997. PMID: 9230693 Review.
• [Regulation of hematopoiesis by transcription factors].
  Kurokawa M, Hirai H. Kurokawa M, et al. Tanpakushitsu Kakusan Koso. 2000 Jun;45(9 Suppl):1565-72. Tanpakushitsu Kakusan Koso. 2000. PMID: 10879135 Review. Japanese. No abstract available.

Cited by

• Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq.
  Wang B, Wang C, Wan Y, Gao J, Ma Y, Zhang Y, Tong J, Zhang Y, Liu J, Chang L, Xu C, Shen B, Chen Y, Jiang E, Kurita R, Nakamura Y, Lim KC, Engel JD, Zhou J, Cheng T, Zhu X, Zhu P, Shi L. Wang B, et al. Cell Discov. 2022 May 10;8(1):41. doi: 10.1038/s41421-022-00389-z. Cell Discov. 2022. PMID: 35534476 Free PMC article.
• MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia.
  Lu Q, Guo P, Wang X, Ares I, Lopez-Torres B, Martínez-Larrañaga MR, Li T, Zhang Y, Wang X, Anadón A, Martínez MA. Lu Q, et al. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28. Cell Biol Toxicol. 2023. PMID: 34581912
• Identifying Cell-Type Specific Genes and Expression Rules Based on Single-Cell Transcriptomic Atlas Data.
  Yuan F, Pan X, Zeng T, Zhang YH, Chen L, Gan Z, Huang T, Cai YD. Yuan F, et al. Front Bioeng Biotechnol. 2020 Apr 29;8:350. doi: 10.3389/fbioe.2020.00350. eCollection 2020. Front Bioeng Biotechnol. 2020. PMID: 32411685 Free PMC article.
• Recurrent deletions of IKZF1 in pediatric acute myeloid leukemia.
  de Rooij JD, Beuling E, van den Heuvel-Eibrink MM, Obulkasim A, Baruchel A, Trka J, Reinhardt D, Sonneveld E, Gibson BE, Pieters R, Zimmermann M, Zwaan CM, Fornerod M. de Rooij JD, et al. Haematologica. 2015 Sep;100(9):1151-9. doi: 10.3324/haematol.2015.124321. Epub 2015 Jun 11. Haematologica. 2015. PMID: 26069293 Free PMC article. Clinical Trial.
• The Saguenay-Lac-Saint-Jean asthma familial collection: the genetics of asthma in a young founder population.
  Laprise C. Laprise C. Genes Immun. 2014 Apr;15(4):247-55. doi: 10.1038/gene.2014.12. Epub 2014 Mar 20. Genes Immun. 2014. PMID: 24646526

Publication types

MeSH terms

Substances

LinkOut - more resources

• Other Literature Sources

  • The Lens - Patent Citations

• Medical

  • MedlinePlus Health Information