Evidence for altered synthesis of type II collagen in patients with osteoarthritis - PubMed (original) (raw)

. 1998 Dec 15;102(12):2115-25.

doi: 10.1172/JCI4853.

L Dahlberg, S Laverty, A Reiner, I Pidoux, M Ionescu, G L Fraser, E Brooks, M Tanzer, L C Rosenberg, P Dieppe, A Robin Poole

Affiliations

• PMID: 9854047
• PMCID: PMC509166
• DOI: 10.1172/JCI4853

Evidence for altered synthesis of type II collagen in patients with osteoarthritis

F Nelson et al. J Clin Invest. 1998.

Abstract

There is evidence to suggest that the synthesis of type II collagen is increased in osteoarthritis (OA). Using an immunoassay, we show that the content of the C-propeptide of type II procollagen (CPII), released extracellularly from the newly synthesized molecule, is directly related to the synthesis of this molecule in healthy and osteoarthritic articular cartilages. In OA cartilage, CPII content is often markedly elevated (mean 7.6-fold), particularly in the mid and deep zones, reaching 29.6% of the content in newborn. Synthesis is also directly related to total collagen II content in OA, suggesting its importance in maintaining collagen content and cartilage structure. The release of CPII from cartilage is correlated directly with cartilage content. However, the increase in CPII in OA cartilage is not reflected in serum, where a significant reduction is observed. Together these studies provide evidence for alterations in procollagen II synthesis in vivo in patients with OA.

PubMed Disclaimer

Similar articles

• The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis.
  Squires GR, Okouneff S, Ionescu M, Poole AR. Squires GR, et al. Arthritis Rheum. 2003 May;48(5):1261-70. doi: 10.1002/art.10976. Arthritis Rheum. 2003. PMID: 12746899
• Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis.
  Garnero P, Ayral X, Rousseau JC, Christgau S, Sandell LJ, Dougados M, Delmas PD. Garnero P, et al. Arthritis Rheum. 2002 Oct;46(10):2613-24. doi: 10.1002/art.10576. Arthritis Rheum. 2002. PMID: 12384919
• Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1).
  Dahlberg L, Billinghurst RC, Manner P, Nelson F, Webb G, Ionescu M, Reiner A, Tanzer M, Zukor D, Chen J, van Wart HE, Poole AR. Dahlberg L, et al. Arthritis Rheum. 2000 Mar;43(3):673-82. doi: 10.1002/1529-0131(200003)43:3<673::AID-ANR25>3.0.CO;2-8. Arthritis Rheum. 2000. PMID: 10728762
• The role of type IX collagen in osteoarthritis and rheumatoid arthritis.
  Diab M. Diab M. Orthop Rev. 1993 Feb;22(2):165-70. Orthop Rev. 1993. PMID: 8451069 Review.
• [Regulation of collagen from the cartilage by interleukin-1].
  Goldring MB. Goldring MB. Rev Prat. 1996 Dec 1;46(19 Spec No):S32-6. Rev Prat. 1996. PMID: 8978155 Review. French. No abstract available.

Cited by

• Effects of Etanercept and Adalimumab on Serum Levels of Cartilage Remodeling Markers in Women with Rheumatoid Arthritis.
  Szeremeta A, Jura-Półtorak A, Zoń-Giebel A, Olczyk K, Komosińska-Vassev K. Szeremeta A, et al. J Clin Med. 2023 Aug 9;12(16):5185. doi: 10.3390/jcm12165185. J Clin Med. 2023. PMID: 37629227 Free PMC article.
• In-silico assessment of high-risk non-synonymous SNPs in ADAMTS3 gene associated with Hennekam syndrome and their impact on protein stability and function.
  Shinwari K, Wu Y, Rehman HM, Xiao N, Bolkov M, Tuzankina I, Chereshnev V. Shinwari K, et al. BMC Bioinformatics. 2023 Jun 15;24(1):251. doi: 10.1186/s12859-023-05361-6. BMC Bioinformatics. 2023. PMID: 37322437 Free PMC article.
• Matrix metalloproteinases in arthritis: towards precision medicine.
  Grillet B, Pereira RVS, Van Damme J, Abu El-Asrar A, Proost P, Opdenakker G. Grillet B, et al. Nat Rev Rheumatol. 2023 Jun;19(6):363-377. doi: 10.1038/s41584-023-00966-w. Epub 2023 May 9. Nat Rev Rheumatol. 2023. PMID: 37161083 Review.
• Collagen type II: From biosynthesis to advanced biomaterials for cartilage engineering.
  Wu Z, Korntner SH, Mullen AM, Zeugolis DI. Wu Z, et al. Biomater Biosyst. 2021 Nov 22;4:100030. doi: 10.1016/j.bbiosy.2021.100030. eCollection 2021 Dec. Biomater Biosyst. 2021. PMID: 36824570 Free PMC article. Review.
• A Highly Sensitive Biomarker of Type II Collagen C-Terminal Pro-Peptide Associated with Cartilage Formation.
  Port H, Bay-Jensen AC, He Y, Karsdal MA, Gantzel T, Thudium CS, Holm Nielsen S. Port H, et al. Int J Mol Sci. 2022 Dec 27;24(1):454. doi: 10.3390/ijms24010454. Int J Mol Sci. 2022. PMID: 36613894 Free PMC article.

References

1. 1. J Bone Joint Surg Am. 1971 Apr;53(3):523-37 - PubMed
2. 1. Biochim Biophys Acta. 1973 Feb 28;297(2):456-72 - PubMed
3. 1. Biochem J. 1974 Feb;137(2):387-98 - PubMed
4. 1. J Clin Invest. 1977 Apr;59(4):593-600 - PubMed
5. 1. J Bone Joint Surg Am. 1979 Apr;61(3):407-16 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • American Society for Clinical Investigation
  • Europe PubMed Central
  • Ovid Technologies, Inc.
  • PubMed Central

• Other Literature Sources

  • The Lens - Patent Citations

• Medical

  • MedlinePlus Health Information