Activity-dependent modulation of synaptic AMPA receptor accumulation - PubMed (original) (raw)
Activity-dependent modulation of synaptic AMPA receptor accumulation
R J O'Brien et al. Neuron. 1998 Nov.
Free article
Abstract
Both theoretical and experimental work have suggested that central neurons compensate for changes in excitatory synaptic input in order to maintain a relatively constant output. We report here that inhibition of excitatory synaptic transmission in cultured spinal neurons leads to an increase in mEPSC amplitudes, accompanied by an equivalent increase in the accumulation of AMPA receptors at synapses. Conversely, increasing excitatory synaptic activity leads to a decrease in synaptic AMPA receptors and a decline in mEPSC amplitude. The time course of this synaptic remodeling is slow, similar to the metabolic half-life of neuronal AMPA receptors. Moreover, inhibiting excitatory synaptic transmission significantly prolongs the half-life of the AMPA receptor subunit GluR1, suggesting that synaptic activity modulates the size of the mEPSC by regulating the turnover of postsynaptic AMPA receptors.
Comment in
- Thinking globally, acting locally: AMPA receptor turnover and synaptic strength.
Turrigiano GG, Nelson SB. Turrigiano GG, et al. Neuron. 1998 Nov;21(5):933-5. doi: 10.1016/s0896-6273(00)80607-8. Neuron. 1998. PMID: 9856445 Review. No abstract available.
Similar articles
- Properties of miniature glutamatergic EPSCs in neurons of the locomotor regions of the developing zebrafish.
Ali DW, Buss RR, Drapeau P. Ali DW, et al. J Neurophysiol. 2000 Jan;83(1):181-91. doi: 10.1152/jn.2000.83.1.181. J Neurophysiol. 2000. PMID: 10634865 - Input- and subunit-specific AMPA receptor trafficking underlying long-term potentiation at hippocampal CA3 synapses.
Kakegawa W, Tsuzuki K, Yoshida Y, Kameyama K, Ozawa S. Kakegawa W, et al. Eur J Neurosci. 2004 Jul;20(1):101-10. doi: 10.1111/j.1460-9568.2004.03461.x. Eur J Neurosci. 2004. PMID: 15245483 - Activity- and BDNF-induced plasticity of miniature synaptic currents in ES cell-derived neurons integrated in a neocortical network.
Copi A, Jüngling K, Gottmann K. Copi A, et al. J Neurophysiol. 2005 Dec;94(6):4538-43. doi: 10.1152/jn.00155.2005. J Neurophysiol. 2005. PMID: 16293594 - Interacting partners of AMPA-type glutamate receptors.
Cheng J, Dong J, Cui Y, Wang L, Wu B, Zhang C. Cheng J, et al. J Mol Neurosci. 2012 Oct;48(2):441-7. doi: 10.1007/s12031-012-9724-6. Epub 2012 Feb 24. J Mol Neurosci. 2012. PMID: 22361832 Review. - AMPA-silent synapses in brain development and pathology.
Hanse E, Seth H, Riebe I. Hanse E, et al. Nat Rev Neurosci. 2013 Dec;14(12):839-50. doi: 10.1038/nrn3642. Epub 2013 Nov 8. Nat Rev Neurosci. 2013. PMID: 24201185 Review.
Cited by
- Trophic factor-induced activity 'signature' regulates the functional expression of postsynaptic excitatory acetylcholine receptors required for synaptogenesis.
Luk CC, Lee AJ, Wijdenes P, Zaidi W, Leung A, Wong NY, Andrews J, Syed NI. Luk CC, et al. Sci Rep. 2015 Apr 1;5:9523. doi: 10.1038/srep09523. Sci Rep. 2015. PMID: 25827640 Free PMC article. - Activity-Dependent Global Downscaling of Evoked Neurotransmitter Release across Glutamatergic Inputs in Drosophila.
Karunanithi S, Lin YQ, Odierna GL, Menon H, Gonzalez JM, Neely GG, Noakes PG, Lavidis NA, Moorhouse AJ, van Swinderen B. Karunanithi S, et al. J Neurosci. 2020 Oct 14;40(42):8025-8041. doi: 10.1523/JNEUROSCI.0349-20.2020. Epub 2020 Sep 14. J Neurosci. 2020. PMID: 32928887 Free PMC article. - Cortical and Subcortical Circuits for Cross-Modal Plasticity Induced by Loss of Vision.
Ewall G, Parkins S, Lin A, Jaoui Y, Lee HK. Ewall G, et al. Front Neural Circuits. 2021 May 25;15:665009. doi: 10.3389/fncir.2021.665009. eCollection 2021. Front Neural Circuits. 2021. PMID: 34113240 Free PMC article. - In vivo synaptic scaling is mediated by GluA2-lacking AMPA receptors in the embryonic spinal cord.
Garcia-Bereguiain MA, Gonzalez-Islas C, Lindsly C, Butler E, Hill AW, Wenner P. Garcia-Bereguiain MA, et al. J Neurosci. 2013 Apr 17;33(16):6791-9. doi: 10.1523/JNEUROSCI.4025-12.2013. J Neurosci. 2013. PMID: 23595738 Free PMC article. - Learning cross-modal spatial transformations through spike timing-dependent plasticity.
Davison AP, Frégnac Y. Davison AP, et al. J Neurosci. 2006 May 24;26(21):5604-15. doi: 10.1523/JNEUROSCI.5263-05.2006. J Neurosci. 2006. PMID: 16723517 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources