Interleukin-13: central mediator of allergic asthma - PubMed (original) (raw)
Interleukin-13: central mediator of allergic asthma
M Wills-Karp et al. Science. 1998.
Abstract
The worldwide incidence, morbidity, and mortality of allergic asthma are increasing. The pathophysiological features of allergic asthma are thought to result from the aberrant expansion of CD4(+) T cells producing the type 2 cytokines interleukin-4 (IL-4) and IL-5, although a necessary role for these cytokines in allergic asthma has not been demonstrable. The type 2 cytokine IL-13, which shares a receptor component and signaling pathways with IL-4, was found to be necessary and sufficient for the expression of allergic asthma. IL-13 induces the pathophysiological features of asthma in a manner that is independent of immunoglobulin E and eosinophils. Thus, IL-13 is critical to allergen-induced asthma but operates through mechanisms other than those that are classically implicated in allergic responses.
Comment in
- Science. 1999 May 28;284(5419):1431
- Interleukin-13's key role in asthma shown.
Vogel G. Vogel G. Science. 1998 Dec 18;282(5397):2168. doi: 10.1126/science.282.5397.2168a. Science. 1998. PMID: 9890820 No abstract available.
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