Integrin-associated protein is a ligand for the P84 neural adhesion molecule - PubMed (original) (raw)

. 1999 Jan 8;274(2):559-62.

doi: 10.1074/jbc.274.2.559.

Affiliations

• PMID: 9872987
• DOI: 10.1074/jbc.274.2.559

Free article

Integrin-associated protein is a ligand for the P84 neural adhesion molecule

P Jiang et al. J Biol Chem. 1999.

Free article

Abstract

P84 (also known as SHPS-1, BIT, and SIRP) is a heterophilic adhesive membrane protein involved in receptor tyrosine kinase signaling that is found at synapses in the mammalian central nervous system and in non-neural tissues. We have identified a binding partner for P84 using an expression cloning strategy. Here we report that integrin-associated protein (IAP/CD47) is a predominant binding partner of P84. Immunohistochemistry reveals a virtually identical distribution of P84 and IAP in a variety of adult brain regions. Because IAP has been implicated in cell signaling in cells of the immune system, P84 and IAP represent a heterophilic binding pair that is likely to be involved in bi-directional signaling at the synapse and in other tissues.

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