NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists - PubMed (original) (raw)
NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists
J Yuan et al. Bioorg Med Chem Lett. 1998.
Abstract
N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-3-fluorenylcarboxamide and N-(4-[4-¿2, 3-dichlorophenyl¿-1-piperazinyl]butyl)-2-biphenylenylcarboxamide were prepared in several steps from 2,3-dichloroaniline. These compounds were identified as highly selective dopamine D3 receptor antagonists.
Similar articles
- Effects of two novel D3-selective compounds, NGB 2904 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-9H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the reinforcing and discriminative stimulus effects of cocaine in rhesus monkeys.
Martelle JL, Claytor R, Ross JT, Reboussin BA, Newman AH, Nader MA. Martelle JL, et al. J Pharmacol Exp Ther. 2007 May;321(2):573-82. doi: 10.1124/jpet.106.113571. Epub 2007 Feb 1. J Pharmacol Exp Ther. 2007. PMID: 17272677 - Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype.
Robarge MJ, Husbands SM, Kieltyka A, Brodbeck R, Thurkauf A, Newman AH. Robarge MJ, et al. J Med Chem. 2001 Sep 13;44(19):3175-86. doi: 10.1021/jm010146o. J Med Chem. 2001. PMID: 11543687 - Pharmacological actions of NGB 2904, a selective dopamine D3 receptor antagonist, in animal models of drug addiction.
Xi ZX, Gardner EL. Xi ZX, et al. CNS Drug Rev. 2007 Summer;13(2):240-59. doi: 10.1111/j.1527-3458.2007.00013.x. CNS Drug Rev. 2007. PMID: 17627675 Free PMC article. Review. - N-(4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl)arylcarboxamides as novel dopamine D(3) receptor antagonists.
Newman AH, Cao J, Bennett CJ, Robarge MJ, Freeman RA, Luedtke RR. Newman AH, et al. Bioorg Med Chem Lett. 2003 Jul 7;13(13):2179-83. doi: 10.1016/s0960-894x(03)00389-5. Bioorg Med Chem Lett. 2003. PMID: 12798330 - Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonist.
Dubuffet T, Newman-Tancredi A, Cussac D, Audinot V, Loutz A, Millan MJ, Lavielle G. Dubuffet T, et al. Bioorg Med Chem Lett. 1999 Jul 19;9(14):2059-64. doi: 10.1016/s0960-894x(99)00312-1. Bioorg Med Chem Lett. 1999. PMID: 10450981
Cited by
- Dopamine Receptor Ligand Selectivity-An In Silico/In Vitro Insight.
Zell L, Bretl A, Temml V, Schuster D. Zell L, et al. Biomedicines. 2023 May 17;11(5):1468. doi: 10.3390/biomedicines11051468. Biomedicines. 2023. PMID: 37239139 Free PMC article. - Design and Synthesis of Conformationally Flexible Scaffold as Bitopic Ligands for Potent D3-Selective Antagonists.
Kim HY, Lee JY, Hsieh CJ, Taylor M, Luedtke RR, Mach RH. Kim HY, et al. Int J Mol Sci. 2022 Dec 27;24(1):432. doi: 10.3390/ijms24010432. Int J Mol Sci. 2022. PMID: 36613875 Free PMC article. - Approach to the specificity and selectivity between D2 and D3 receptors by mutagenesis and binding experiments part I: Expression and characterization of D2 and D3 receptor mutants.
Legros C, Rojas A, Dupré C, Brasseur C, Riest-Fery I, Muller O, Ortuno JC, Nosjean O, Guenin SP, Ferry G, Boutin JA. Legros C, et al. Protein Sci. 2022 Dec;31(12):e4459. doi: 10.1002/pro.4459. Protein Sci. 2022. PMID: 36177735 Free PMC article. - Neurobiological and Pharmacological Perspectives of D3 Receptors in Parkinson's Disease.
Chagraoui A, Di Giovanni G, De Deurwaerdère P. Chagraoui A, et al. Biomolecules. 2022 Feb 1;12(2):243. doi: 10.3390/biom12020243. Biomolecules. 2022. PMID: 35204744 Free PMC article. Review. - Dopamine D3 receptor-based medication development for the treatment of opioid use disorder: Rationale, progress, and challenges.
Galaj E, Newman AH, Xi ZX. Galaj E, et al. Neurosci Biobehav Rev. 2020 Jul;114:38-52. doi: 10.1016/j.neubiorev.2020.04.024. Epub 2020 May 3. Neurosci Biobehav Rev. 2020. PMID: 32376243 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Chemical Information