An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons - PubMed (original) (raw)
An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons
A Bulfone et al. Neuron. 1998 Dec.
Free article
Abstract
Olfactory sensory neurons expressing a given odorant receptor project to two topographically fixed glomeruli in the olfactory bulb. We have examined the contribution of different cell types in the olfactory bulb to the establishment of this topographic map. Mice with a homozygous deficiency in Tbr-1 lack most projection neurons, whereas mice with a homozygous deficiency in Dlx-1 and Dlx-2 lack most GABAergic interneurons. Mice bearing a P2-IRES-tau-lacZ allele and deficient in either Tbr-1 or Dlx-1/Dlx-2 reveal the convergence of axons to one medial and one lateral site at positions analogous to those observed in wild-type mice. These observations suggest that the establishment of a topographic map is not dependent upon cues provided by, or synapse formation with, the major neuronal cell types in the olfactory bulb.
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- K02 MH01046-01/MH/NIMH NIH HHS/United States
- TGM97000/TI_/Telethon/Italy
- NS01973-02/NS/NINDS NIH HHS/United States
- TGM06S01/TI_/Telethon/Italy
- NS34661-01A1/NS/NINDS NIH HHS/United States
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