Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse - PubMed (original) (raw)
. 1999 Jan 15;93(2):590-8.
Affiliations
- PMID: 9885220
Free article
Definition of dendritic cell subpopulations present in the spleen, Peyer's patches, lymph nodes, and skin of the mouse
F Anjuère et al. Blood. 1999.
Free article
Abstract
Dendritic cells (DC) are highly efficient antigen-presenting cells (APC) that have an essential function in the development of immune responses against microbial pathogens and tumors. Although during the past few years our understanding of DC biology has remarkably increased, a precise characterization of the different DC subpopulations remains to be achieved with regard to their phenotype and lineage relationships. In this report, we have extensively studied the DC subpopulations present in the thymus, spleen, Peyer's patches, lymph nodes (LN) and skin of the mouse. Thymus DC and 60% spleen DC have a lymphoid DC phenotype, ie, CD8(+) DEC-205(high) Mac-1(low), whereas 40% spleen DC have a myeloid DC phenotype, ie, CD8(-) DEC-205(low) Mac-1(high). Both CD8(+) and CD8(-) DC are leukocyte function-associated antigen-1 (LFA-1)high and highly adherent. Within Peyer's patches the majority of DC correspond to the CD8(+) DEC-205(high) Mac-1(low) lymphoid category. In the LN, together with CD8(+) and CD8(-) DC, an additional nonadherent CD8(int) LFA-1(int) subpopulation with lymphoid DC characteristics is described. Finally, in the skin both epidermal Langerhans cells (LC) and dermal DC are CD8(-)DEC-205(high) Mac-1 (high), and do not express LFA-1. Interestingly, LC migration experiments indicate that LC underwent the upregulation of CD8 and LFA-1 upon migration to the LN, supporting the hypothesis that LC belong to the CD8(+) lymphoid lineage.
Similar articles
- Unique functions of CD11b+, CD8 alpha+, and double-negative Peyer's patch dendritic cells.
Iwasaki A, Kelsall BL. Iwasaki A, et al. J Immunol. 2001 Apr 15;166(8):4884-90. doi: 10.4049/jimmunol.166.8.4884. J Immunol. 2001. PMID: 11290765 - DEC-205 as a marker of dendritic cells with regulatory effects on CD8 T cell responses.
Kronin V, Wu L, Gong S, Nussenzweig MC, Shortman K. Kronin V, et al. Int Immunol. 2000 May;12(5):731-5. doi: 10.1093/intimm/12.5.731. Int Immunol. 2000. PMID: 10784619 - Phenotype and function of murine discrete Peyer's patch macrophage derived - dendritic cells.
Makala LH, Reyes JC, Nishikawa Y, Tsushima Y, Xuan X, Huang X, Battsetseg B, Matsuo T, Nagasawa H. Makala LH, et al. J Vet Med Sci. 2003 Apr;65(4):491-9. doi: 10.1292/jvms.65.491. J Vet Med Sci. 2003. PMID: 12736432 - Specific lymphocyte-endothelial cell interactions regulate migration into lymph nodes, Peyer's patches, and skin.
Chin YH, Falanga V, Streilein JW, Sackstein R. Chin YH, et al. Reg Immunol. 1988 Jul-Aug;1(1):78-83. Reg Immunol. 1988. PMID: 3079311 Review. - Langerin-expressing dendritic cells in gut-associated lymphoid tissues.
Chang SY, Kweon MN. Chang SY, et al. Immunol Rev. 2010 Mar;234(1):233-46. doi: 10.1111/j.0105-2896.2009.00878.x. Immunol Rev. 2010. PMID: 20193022 Review.
Cited by
- CD8alpha- CD11b+ dendritic cells present exogenous virus-like particles to CD8+ T cells and subsequently express CD8alpha and CD205 molecules.
Morón G, Rueda P, Casal I, Leclerc C. Morón G, et al. J Exp Med. 2002 May 20;195(10):1233-45. doi: 10.1084/jem.20011930. J Exp Med. 2002. PMID: 12021304 Free PMC article. - Protective mucosal Th2 immune response against Toxoplasma gondii by murine mesenteric lymph node dendritic cells.
Dimier-Poisson I, Aline F, Mévélec MN, Beauvillain C, Buzoni-Gatel D, Bout D. Dimier-Poisson I, et al. Infect Immun. 2003 Sep;71(9):5254-65. doi: 10.1128/IAI.71.9.5254-5265.2003. Infect Immun. 2003. PMID: 12933872 Free PMC article. - Flt3 ligand generates morphologically distinct semimature dendritic cells in ovalbumin-sensitized mice.
Bharadwaj AS, Agrawal DK. Bharadwaj AS, et al. Exp Mol Pathol. 2007 Aug;83(1):17-24. doi: 10.1016/j.yexmp.2006.09.007. Epub 2006 Dec 19. Exp Mol Pathol. 2007. PMID: 17182033 Free PMC article. - Immunization with radiation-attenuated Plasmodium berghei sporozoites induces liver cCD8alpha+DC that activate CD8+T cells against liver-stage malaria.
Jobe O, Donofrio G, Sun G, Liepinsh D, Schwenk R, Krzych U. Jobe O, et al. PLoS One. 2009;4(4):e5075. doi: 10.1371/journal.pone.0005075. Epub 2009 Apr 4. PLoS One. 2009. PMID: 19347042 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
Miscellaneous