NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities - PubMed (original) (raw)
NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
Y Xue et al. Mol Cell. 1998 Dec.
Free article
Abstract
ATP-dependent chromatin-remodeling complexes are known to facilitate transcriptional activation by opening chromatin structures. We report a novel human complex, named NURD, which contains not only ATP-dependent nucleosome disruption activity, but also histone deacetylase activity, which usually associates with transcriptional repression. The deacetylation is stimulated by ATP on nucleosomal templates, suggesting that nucleosome disruption aids the deacetylase to access its substrates. One subunit of NURD was identified as MTA1, a metastasis-associated protein with a region similar to the nuclear receptor core-pressor, N-CoR; and antibodies against NURD partially relieve transcriptional repression by thyroid hormone receptor. These results suggest that ATP-dependent chromatin remodeling can participate in transcriptional repression by assisting repressors in gaining access to chromatin.
Similar articles
- Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex.
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL. Tong JK, et al. Nature. 1998 Oct 29;395(6705):917-21. doi: 10.1038/27699. Nature. 1998. PMID: 9804427 - Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D. Zhang Y, et al. Genes Dev. 1999 Aug 1;13(15):1924-35. doi: 10.1101/gad.13.15.1924. Genes Dev. 1999. PMID: 10444591 Free PMC article. - An ikaros-containing chromatin-remodeling complex in adult-type erythroid cells.
O'Neill DW, Schoetz SS, Lopez RA, Castle M, Rabinowitz L, Shor E, Krawchuk D, Goll MG, Renz M, Seelig HP, Han S, Seong RH, Park SD, Agalioti T, Munshi N, Thanos D, Erdjument-Bromage H, Tempst P, Bank A. O'Neill DW, et al. Mol Cell Biol. 2000 Oct;20(20):7572-82. doi: 10.1128/MCB.20.20.7572-7582.2000. Mol Cell Biol. 2000. PMID: 11003653 Free PMC article. - The NuRD complex: linking histone modification to nucleosome remodeling.
Feng Q, Zhang Y. Feng Q, et al. Curr Top Microbiol Immunol. 2003;274:269-90. doi: 10.1007/978-3-642-55747-7_10. Curr Top Microbiol Immunol. 2003. PMID: 12596911 Review. - ATP-dependent nucleosome remodeling.
Becker PB, Hörz W. Becker PB, et al. Annu Rev Biochem. 2002;71:247-73. doi: 10.1146/annurev.biochem.71.110601.135400. Epub 2001 Nov 9. Annu Rev Biochem. 2002. PMID: 12045097 Review.
Cited by
- NuRD chromatin remodeling is required to repair exogenous DSBs in the Caenorhabditis elegans germline.
Ananthaswamy D, Funes K, Borges T, Roques S, Fassnacht N, Jamal SE, Checchi PM, Wei-Sy Lee T. Ananthaswamy D, et al. bioRxiv [Preprint]. 2024 Sep 15:2024.09.14.613027. doi: 10.1101/2024.09.14.613027. bioRxiv. 2024. PMID: 39314477 Free PMC article. Preprint. - Insights gained from computational modeling of YAP/TAZ signaling for cellular mechanotransduction.
Jafarinia H, Khalilimeybodi A, Barrasa-Fano J, Fraley SI, Rangamani P, Carlier A. Jafarinia H, et al. NPJ Syst Biol Appl. 2024 Aug 15;10(1):90. doi: 10.1038/s41540-024-00414-9. NPJ Syst Biol Appl. 2024. PMID: 39147782 Free PMC article. Review. - De novo missense variants in HDAC3 leading to epigenetic machinery dysfunction are associated with a variable neurodevelopmental disorder.
Yoon JG, Lim SK, Seo H, Lee S, Cho J, Kim SY, Koh HY, Poduri AH, Ramakumaran V, Vasudevan P, de Groot MJ, Ko JM, Han D, Chae JH, Lee CH. Yoon JG, et al. Am J Hum Genet. 2024 Aug 8;111(8):1588-1604. doi: 10.1016/j.ajhg.2024.06.015. Epub 2024 Jul 23. Am J Hum Genet. 2024. PMID: 39047730 Free PMC article. - A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin.
Gu W, Huang X, Singh PNP, Li S, Lan Y, Deng M, Lacko LA, Gomez-Salinero JM, Rafii S, Verzi MP, Shivdasani RA, Zhou Q. Gu W, et al. Nat Commun. 2024 Apr 27;15(1):3595. doi: 10.1038/s41467-024-47738-y. Nat Commun. 2024. PMID: 38678016 Free PMC article. - CARM1 hypermethylates the NuRD chromatin remodeling complex to promote cell cycle gene expression and breast cancer development.
Chen X, Huang MF, Fan DM, He YH, Zhang WJ, Ding JC, Peng BL, Pan X, Liu Y, Du J, Li Y, Liu ZY, Xie BL, Kuang ZJ, Yi J, Liu W. Chen X, et al. Nucleic Acids Res. 2024 Jul 8;52(12):6811-6829. doi: 10.1093/nar/gkae329. Nucleic Acids Res. 2024. PMID: 38676947 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases
Research Materials
Miscellaneous