Linkage disequilibrium mapping of complex disease: fantasy or reality? - PubMed (original) (raw)

Review

Linkage disequilibrium mapping of complex disease: fantasy or reality?

J D Terwilliger et al. Curr Opin Biotechnol. 1998 Dec.

Free article

Abstract

In the past year, data about the level and nature of linkage disequilibrium between alleles of tightly linked SNPs have started to become available. Furthermore, increasing evidence of allelic heterogeneity at the loci predisposing to complex disease has been observed, which has lead to initial attempts to develop methods of linkage disequilibrium detection allowing for this difficulty. It has also become more obvious that we will need to think carefully about the types of populations we need to analyze in an attempt to identify these elusive genes, and it is becoming clear that we need to carefully re-evaluate the prognosis of the current paradigm with regard to its robustness to the types of problems that are likely to exist.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources