Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy - PubMed (original) (raw)
Amelioration of collagen-induced arthritis and suppression of interferon-gamma, interleukin-12, and tumor necrosis factor alpha production by interferon-beta gene therapy
K A Triantaphyllopoulos et al. Arthritis Rheum. 1999 Jan.
Free article
Abstract
Objective: To investigate the therapeutic effects and possible mechanisms of action of constitutive expression of interferon-beta (IFNbeta) by syngeneic fibroblasts from DBA/1 mice in the collagen-induced arthritis (CIA) model.
Methods: Immortalized embryonic DBA/1 fibroblasts were infected with a retrovirus expressing murine IFNbeta. IFNbeta-expressing fibroblasts were then implanted intraperitoneally into mice immunized with bovine type II collagen. The effect of IFNbeta on paw swelling, anticollagen antibody levels, IgG1/IgG2a isotype profiles, arthritis score, histologic joint damage, and cytokine secretion from lymph node cells and from bone marrow-derived macrophages was assessed.
Results: A single injection of IFNbeta-secreting fibroblasts was sufficient to prevent arthritis or to ameliorate existing disease. Thus, IFNbeta reduced the clinical score and paw swelling irrespective of whether the injection was administered before or after disease onset in treated mice, compared with that in the untreated control group (P < 0.05). Histologic findings in the IFNbeta-treated mice were markedly less severe than in the control group (P < 0.001). This effect was accompanied by a decrease in total anticollagen IgG levels, a decrease in anticollagen IgG2a, and an increase in IgG1. In vitro, supernatants from these engineered fibroblasts inhibited collagen-induced interferon-gamma secretion from lymph node cells, and reduced the levels of tumor necrosis factor alpha and interleukin-12 produced by lipopolysaccharide/IFNgamma-treated bone marrow-derived macrophages. This effect was specific, since it was reversed with anti-IFNbeta polyclonal antibodies.
Conclusion: These results indicate that IFNbeta, which is currently used as a treatment for relapsing, remitting multiple sclerosis, is a potent immunomodulatory and antiinflammatory cytokine in CIA and should be considered for the treatment of rheumatoid arthritis.
Similar articles
- Mechanisms of effects of complement inhibition in murine collagen-induced arthritis.
Banda NK, Kraus D, Vondracek A, Huynh LH, Bendele A, Holers VM, Arend WP. Banda NK, et al. Arthritis Rheum. 2002 Nov;46(11):3065-75. doi: 10.1002/art.10591. Arthritis Rheum. 2002. PMID: 12428251 - Stromal cells and osteoclasts are responsible for exacerbated collagen-induced arthritis in interferon-beta-deficient mice.
Treschow AP, Teige I, Nandakumar KS, Holmdahl R, Issazadeh-Navikas S. Treschow AP, et al. Arthritis Rheum. 2005 Dec;52(12):3739-48. doi: 10.1002/art.21496. Arthritis Rheum. 2005. PMID: 16320324 - Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipram.
Ross SE, Williams RO, Mason LJ, Mauri C, Marinova-Mutafchieva L, Malfait AM, Maini RN, Feldmann M. Ross SE, et al. J Immunol. 1997 Dec 15;159(12):6253-9. J Immunol. 1997. PMID: 9550429 - Cytokine-based immunomodulation of autoimmune diseases: an overview.
Bach JF. Bach JF. Transplant Proc. 1996 Dec;28(6):3023-5. Transplant Proc. 1996. PMID: 8962173 Review. No abstract available. - In vivo modulation of murine collagen induced arthritis.
Ranges GE, Fortin S, Barger MT, Sriram S, Cooper SM. Ranges GE, et al. Int Rev Immunol. 1988 Sep;4(1):83-90. doi: 10.3109/08830188809044772. Int Rev Immunol. 1988. PMID: 3149663 Review.
Cited by
- The Effects of Nicotine and Cannabinoids on Cytokines.
Miller G, Pareek O, Penman SL, Thanos PK. Miller G, et al. Curr Pharm Des. 2024;30(31):2468-2484. doi: 10.2174/0113816128293077240529111824. Curr Pharm Des. 2024. PMID: 38859790 Review. - A comprehensive transcriptomic analysis of alternate interferon signaling pathways in peripheral blood mononuclear cells in rheumatoid arthritis.
Han L, Tu S, Shen P, Yan J, Huang Y, Ba X, Li T, Lin W, Li H, Yu K, Guo J, Huang Y, Qin K, Wang Y, Chen Z. Han L, et al. Aging (Albany NY). 2021 Aug 25;13(16):20511-20533. doi: 10.18632/aging.203432. Epub 2021 Aug 25. Aging (Albany NY). 2021. PMID: 34432649 Free PMC article. - Immunoengineering the next generation of arthritis therapies.
Klimak M, Nims RJ, Pferdehirt L, Collins KH, Harasymowicz NS, Oswald SJ, Setton LA, Guilak F. Klimak M, et al. Acta Biomater. 2021 Oct 1;133:74-86. doi: 10.1016/j.actbio.2021.03.062. Epub 2021 Apr 3. Acta Biomater. 2021. PMID: 33823324 Free PMC article. Review. - Cannabis Sativa Revisited-Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis.
Dinu AR, Rogobete AF, Bratu T, Popovici SE, Bedreag OH, Papurica M, Bratu LM, Sandesc D. Dinu AR, et al. Cells. 2020 Jan 28;9(2):307. doi: 10.3390/cells9020307. Cells. 2020. PMID: 32012914 Free PMC article. Review. - TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model.
Huang C, Chen S, Zhang T, Li D, Huang Z, Huang J, Qin Y, Chen B, Cheng G, Ma F, Zhou M. Huang C, et al. Front Immunol. 2019 May 3;10:980. doi: 10.3389/fimmu.2019.00980. eCollection 2019. Front Immunol. 2019. PMID: 31130960 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical