Immune cell entry to the CNS--a focus for immunoregulation of EAE - PubMed (original) (raw)
Review
. 1998 Nov-Dec;149(9):781-9; discussion 844-6, 855-60.
doi: 10.1016/s0923-2494(99)80005-4.
Affiliations
- PMID: 9923633
- DOI: 10.1016/s0923-2494(99)80005-4
Review
Immune cell entry to the CNS--a focus for immunoregulation of EAE
T Owens et al. Res Immunol. 1998 Nov-Dec.
Abstract
T-cell-derived cytokines are therefore individually unnecessary and collectively insufficient for microglial response. This somewhat provocative interpretation does not exclude a role for T-cell cytokines in induction of a microglial response in EAE, but it may be easier to show a non-requirement then to prove such a role. The point that emerges is that cytokine production in the CNS parenchyma is itself dependent on the prior infiltration of immune cells, and that without immune cell entry, EAE does not occur. This identifies events at the BBB, and in particular in the perivascular space, as critical immunoregulatory events in development and progression of EAE.
Similar articles
- Lack of junctional adhesion molecule (JAM)-B ameliorates experimental autoimmune encephalomyelitis.
Tietz S, Périnat T, Greene G, Enzmann G, Deutsch U, Adams R, Imhof B, Aurrand-Lions M, Engelhardt B. Tietz S, et al. Brain Behav Immun. 2018 Oct;73:3-20. doi: 10.1016/j.bbi.2018.06.014. Epub 2018 Jun 18. Brain Behav Immun. 2018. PMID: 29920328 - Experimental allergic encephalomyelitis. T cell trafficking to the central nervous system in a resistant Thy-1 congenic mouse strain.
Skundric DS, Huston K, Shaw M, Tse HY, Raine CS. Skundric DS, et al. Lab Invest. 1994 Nov;71(5):671-9. Lab Invest. 1994. PMID: 7526038 - CD24 on the resident cells of the central nervous system enhances experimental autoimmune encephalomyelitis.
Liu JQ, Carl JW Jr, Joshi PS, RayChaudhury A, Pu XA, Shi FD, Bai XF. Liu JQ, et al. J Immunol. 2007 May 15;178(10):6227-35. doi: 10.4049/jimmunol.178.10.6227. J Immunol. 2007. PMID: 17475850 - Immune cell entry to central nervous system--current understanding and prospective therapeutic targets.
Prendergast CT, Anderton SM. Prendergast CT, et al. Endocr Metab Immune Disord Drug Targets. 2009 Dec;9(4):315-27. doi: 10.2174/187153009789839219. Endocr Metab Immune Disord Drug Targets. 2009. PMID: 20028334 Review. - T cell mediated pathogenesis in EAE: Molecular mechanisms.
Kurschus FC. Kurschus FC. Biomed J. 2015 May-Jun;38(3):183-93. doi: 10.4103/2319-4170.155590. Biomed J. 2015. PMID: 25900928 Review.
Cited by
- Multimodal analysis in acute and chronic experimental autoimmune encephalomyelitis.
Giatti S, Boraso M, Abbiati F, Ballarini E, Calabrese D, Santos-Galindo M, Rigolio R, Pesaresi M, Caruso D, Viviani B, Cavaletti G, Garcia-Segura LM, Melcangi RC. Giatti S, et al. J Neuroimmune Pharmacol. 2013 Mar;8(1):238-50. doi: 10.1007/s11481-012-9385-9. Epub 2012 Jun 30. J Neuroimmune Pharmacol. 2013. PMID: 22870853 - Inhibition of CD40-TRAF6 interactions by the small molecule inhibitor 6877002 reduces neuroinflammation.
Aarts SABM, Seijkens TTP, Kusters PJH, van der Pol SMA, Zarzycka B, Heijnen PDAM, Beckers L, den Toom M, Gijbels MJJ, Boon L, Weber C, de Vries HE, Nicolaes GAF, Dijkstra CD, Kooij G, Lutgens E. Aarts SABM, et al. J Neuroinflammation. 2017 May 12;14(1):105. doi: 10.1186/s12974-017-0875-9. J Neuroinflammation. 2017. PMID: 28494768 Free PMC article. - Cutting edge: critical role for PYCARD/ASC in the development of experimental autoimmune encephalomyelitis.
Shaw PJ, Lukens JR, Burns S, Chi H, McGargill MA, Kanneganti TD. Shaw PJ, et al. J Immunol. 2010 May 1;184(9):4610-4. doi: 10.4049/jimmunol.1000217. Epub 2010 Apr 5. J Immunol. 2010. PMID: 20368281 Free PMC article. - Connexin43, the major gap junction protein of astrocytes, is down-regulated in inflamed white matter in an animal model of multiple sclerosis.
Brand-Schieber E, Werner P, Iacobas DA, Iacobas S, Beelitz M, Lowery SL, Spray DC, Scemes E. Brand-Schieber E, et al. J Neurosci Res. 2005 Jun 15;80(6):798-808. doi: 10.1002/jnr.20474. J Neurosci Res. 2005. PMID: 15898103 Free PMC article. - Interaction between the immune and central nervous systems.
Russell JH. Russell JH. Immunol Res. 2005;32(1-3):225-9. doi: 10.1385/IR:32:1-3:225. Immunol Res. 2005. PMID: 16106074 Review.