Experimental models to study molecular mechanisms underlying intestinal inflammation - PubMed (original) (raw)
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Experimental models to study molecular mechanisms underlying intestinal inflammation
C O Elson et al. Ann N Y Acad Sci. 1998.
Abstract
Experimental animal models, particularly the newer mouse models, have convincingly demonstrated that CD+ T cells play a central role in chronic intestinal inflammation. Such CD4+ effector T cells are induced by the bacterial flora. In at least one model, it is conventional protein antigens that are stimulating these pathogenic T cells. The antigens driving disease seem to be a selective subset of immunodominant proteins, likely derived from a subset of organisms. Multiple genes contribute to colitis susceptibility and a number of these genes are being localized.
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