Experimental models to study molecular mechanisms underlying intestinal inflammation - PubMed (original) (raw)
Review
Experimental models to study molecular mechanisms underlying intestinal inflammation
C O Elson et al. Ann N Y Acad Sci. 1998.
Abstract
Experimental animal models, particularly the newer mouse models, have convincingly demonstrated that CD+ T cells play a central role in chronic intestinal inflammation. Such CD4+ effector T cells are induced by the bacterial flora. In at least one model, it is conventional protein antigens that are stimulating these pathogenic T cells. The antigens driving disease seem to be a selective subset of immunodominant proteins, likely derived from a subset of organisms. Multiple genes contribute to colitis susceptibility and a number of these genes are being localized.
Similar articles
- Colitis in transgenic and knockout animals as models of human inflammatory bowel disease.
Bhan AK, Mizoguchi E, Smith RN, Mizoguchi A. Bhan AK, et al. Immunol Rev. 1999 Jun;169:195-207. doi: 10.1111/j.1600-065x.1999.tb01316.x. Immunol Rev. 1999. PMID: 10450518 Review. - Lessons from genetic models of inflammatory bowel disease.
Podolsky DK. Podolsky DK. Acta Gastroenterol Belg. 1997 Apr-Jun;60(2):163-5. Acta Gastroenterol Belg. 1997. PMID: 9260328 Review. - Animal models of intestinal inflammation: new insights into the molecular pathogenesis and immunotherapy of inflammatory bowel disease.
Wirtz S, Neurath MF. Wirtz S, et al. Int J Colorectal Dis. 2000 Jun;15(3):144-60. doi: 10.1007/s003840000227. Int J Colorectal Dis. 2000. PMID: 10954186 Review. - Mucosal immunity and inflammation. II. The yin and yang of T cells in intestinal inflammation: pathogenic and protective roles in a mouse colitis model.
De Winter H, Cheroutre H, Kronenberg M. De Winter H, et al. Am J Physiol. 1999 Jun;276(6):G1317-21. doi: 10.1152/ajpgi.1999.276.6.G1317. Am J Physiol. 1999. PMID: 10362634 Review.
Cited by
- Anemoside B4 ameliorates TNBS-induced colitis through S100A9/MAPK/NF-κB signaling pathway.
Zhang Y, Zha Z, Shen W, Li D, Kang N, Chen Z, Liu Y, Xu G, Xu Q. Zhang Y, et al. Chin Med. 2021 Jan 18;16(1):11. doi: 10.1186/s13020-020-00410-1. Chin Med. 2021. PMID: 33461587 Free PMC article. - Sodium chloride exacerbates dextran sulfate sodium-induced colitis by tuning proinflammatory and antiinflammatory lamina propria mononuclear cells through p38/MAPK pathway in mice.
Guo HX, Ye N, Yan P, Qiu MY, Zhang J, Shen ZG, He HY, Tian ZQ, Li HL, Li JT. Guo HX, et al. World J Gastroenterol. 2018 Apr 28;24(16):1779-1794. doi: 10.3748/wjg.v24.i16.1779. World J Gastroenterol. 2018. PMID: 29713131 Free PMC article. - Anti-Inflammatory Effect of 3-Bromo-4,5-Dihydroxybenzaldehyde, a Component of Polysiphonia morrowii, In Vivo and In Vitro.
Kang NJ, Han SC, Kang HJ, Ko G, Yoon WJ, Kang HK, Yoo ES. Kang NJ, et al. Toxicol Res. 2017 Oct;33(4):325-332. doi: 10.5487/TR.2017.33.4.325. Epub 2015 Oct 15. Toxicol Res. 2017. PMID: 29071017 Free PMC article. - External Application of Apo-9'-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis.
Han SC, Kang NJ, Yoon WJ, Kim S, Na MC, Koh YS, Hyun JW, Lee NH, Ko MH, Kang HK, Yoo ES. Han SC, et al. Toxicol Res. 2016 Apr;32(2):109-14. doi: 10.5487/TR.2016.32.2.109. Epub 2016 Apr 30. Toxicol Res. 2016. PMID: 27123161 Free PMC article. - Anti-inflammatory effect of Pycnocycla spinosa extract and its component isoacetovanillone on acetic acid induced colitis in rats.
Minaiyan M, Asghari G, Sadraei H, Feili E. Minaiyan M, et al. Res Pharm Sci. 2015 Jul-Aug;10(4):345-55. Res Pharm Sci. 2015. PMID: 26600861 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials