Colocalization of phospholipase D1 and GTP-binding-defective mutant of ADP-ribosylation factor 6 to endosomes and lysosomes - PubMed (original) (raw)
Colocalization of phospholipase D1 and GTP-binding-defective mutant of ADP-ribosylation factor 6 to endosomes and lysosomes
K Toda et al. FEBS Lett. 1999.
Free article
Abstract
Phospholipase D (PLD) is involved in various aspects of cellular function. Two isoforms, PLD1 and PLD2, have been identified. PLD1, which has two splicing variants, is regulated by various factors, including ADP-ribosylation factor (ARF). We here show that both variants of PLD1 are predominantly localized to late endosomes and lysosomes, but not to the Golgi apparatus or endoplasmic reticulum in contrast to earlier studies. Furthermore, PLD1s show significant colocalization with an ARF6 mutant defective in GTP binding. The data suggest that PLD1, under the regulation of ARF6, plays a role in the function of endosomes and lysosomes.
Similar articles
- Localization and regulation of phospholipase D2 by ARF6.
Hiroyama M, Exton JH. Hiroyama M, et al. J Cell Biochem. 2005 May 1;95(1):149-64. doi: 10.1002/jcb.20351. J Cell Biochem. 2005. PMID: 15759270 - Phospholipase D as an effector for ADP-ribosylation factor in the regulation of vesicular traffic.
Roth MG, Bi K, Ktistakis NT, Yu S. Roth MG, et al. Chem Phys Lipids. 1999 Apr;98(1-2):141-52. doi: 10.1016/s0009-3084(99)00026-2. Chem Phys Lipids. 1999. PMID: 10358936 Review. - Brefeldin A: the advantage of being uncompetitive.
Chardin P, McCormick F. Chardin P, et al. Cell. 1999 Apr 16;97(2):153-5. doi: 10.1016/s0092-8674(00)80724-2. Cell. 1999. PMID: 10219235 Review. No abstract available.
Cited by
- Mapping the global interactome of the ARF family reveals spatial organization in cellular signaling pathways.
Quirion L, Robert A, Boulais J, Huang S, Bernal Astrain G, Strakhova R, Jo CH, Kherdjemil Y, Faubert D, Thibault MP, Kmita M, Baskin JM, Gingras AC, Smith MJ, Côté JF. Quirion L, et al. J Cell Sci. 2024 May 1;137(9):jcs262140. doi: 10.1242/jcs.262140. Epub 2024 May 14. J Cell Sci. 2024. PMID: 38606629 Free PMC article. - RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
Hussain SS, Tran TM, Ware TB, Luse MA, Prevost CT, Ferguson AN, Kashatus JA, Hsu KL, Kashatus DF. Hussain SS, et al. Cell Rep. 2021 Jul 27;36(4):109451. doi: 10.1016/j.celrep.2021.109451. Cell Rep. 2021. PMID: 34320341 Free PMC article. - The Interplay of HIV and Autophagy in Early Infection.
Cabrera-Rodríguez R, Pérez-Yanes S, Estévez-Herrera J, Márquez-Arce D, Cabrera C, Espert L, Blanco J, Valenzuela-Fernández A. Cabrera-Rodríguez R, et al. Front Microbiol. 2021 Apr 28;12:661446. doi: 10.3389/fmicb.2021.661446. eCollection 2021. Front Microbiol. 2021. PMID: 33995324 Free PMC article. Review. - Mammalian phospholipase D: Function, and therapeutics.
McDermott MI, Wang Y, Wakelam MJO, Bankaitis VA. McDermott MI, et al. Prog Lipid Res. 2020 Apr;78:101018. doi: 10.1016/j.plipres.2019.101018. Epub 2019 Dec 9. Prog Lipid Res. 2020. PMID: 31830503 Free PMC article. Review. - The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host⁻Pathogen Interactions and Innate Immunity.
Van Acker T, Tavernier J, Peelman F. Van Acker T, et al. Int J Mol Sci. 2019 May 5;20(9):2209. doi: 10.3390/ijms20092209. Int J Mol Sci. 2019. PMID: 31060328 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources