Event-related fMRI of tasks involving brief motion - PubMed (original) (raw)

R M Birn et al. Hum Brain Mapp. 1999.

Abstract

The assessment of brain function by blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) for tasks involving motion near the field of view is compromised by artifacts arising from the motion. The aim of this study is to demonstrate that these artifacts can be reduced by acquiring the average response from a brief stimulus (a "single-trial," or "event-related," paradigm) as opposed to alternating blocks of repeated task with rest (a "block-trial" paradigm). The basis of this technique is that the NMR signal changes from neuronal activation are delayed relative to the motion due to a slow hemodynamic response. By acquiring the average response from a brief stimulus, motion-induced signal changes occur prior to neuronal activation-induced signal changes, and the two can thus be distinguished. This technique is applied to the tasks of speaking out loud, swallowing, jaw clenching, and tongue movement. Functional activation maps derived from the single-trial paradigm contain significantly less artifact than functional activation maps derived from a more traditional block-trial paradigm.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Bandettini PA, Cox RW. 1998. Contrast in single trial fMRI: interstimulus interval dependency and comparison with blocked strategies. In: Proceedings ISMRM Sixth Annual Meeting, Sydney, p 161.
    1. Bandettini PA, Jesmanowicz A, Wong EC, Hyde JS. 1993. Processing strategies for time‐course data sets in functional MRI of the human brain. Magn Reson Med 30:161–173. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=93375843&form... - PubMed
    1. Bandettini PA, Wong EC, Binder JR, Rao SM, Jesmanowicz A, Aaron EA, Lowry TF, Forster HV, Hinks RS, Hyde JS. 1995. Functional MRI using the BOLD approach: dynamic characteristics and data analysis methods In: LeBihan D, editor. Diffusion and perfusion: magnetic resonance imaging. New York: Raven; p 335–349.
    1. Binder JR. 1995. Functional magnetic resonance imaging of language cortex. Int J Imag Syst Tech 6:280–288.
    1. Birn RM, Bandettini PA, Cox RW, Jesmanowicz A, Shaker R. 1998. Magnetic field changes in the human brain due to swallowing or speaking. Magn Reson Med 40:55–60. http://www.ncbi.nlm.nih.gov:80/htbin-post/Entrez/query?uid=98321990&form... - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources