Does fractionation decrease the risk of breast cancer induced by low-LET radiation? - PubMed (original) (raw)

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• PMID: 9952308

Does fractionation decrease the risk of breast cancer induced by low-LET radiation?

D J Brenner. Radiat Res. 1999 Feb.

Abstract

Whether fractionation decreases the risk of breast cancer induced by low-LET radiation is a question of some importance. Analyses of the data for TB cohorts who were exposed to multiple fluoroscopies show an apparently similar breast cancer risk compared with those for the acutely exposed A-bomb survivors. However, the fluoroscopy cohorts were subjected to very much lower-energy photons (60-80 kVp) compared with the A-bomb survivors; the increased RBE associated with the low photon energies to which these fluoroscopy cohorts were exposed suggests that, in comparison to the risk estimates for the A-bomb survivors, the risk estimates from the X-ray fluoroscopy cohorts are increased because of the lower-energy X rays and decreased by a similar amount due to fractionation, resulting in an overall apparent equality of risk. Thus the results from the most powerful epidemiological data sets available for assessing breast cancer risks after fractionated exposure to low-LET radiation (the fluoroscopy cohorts) are quite consistent with a lower radiation risk for a fractionated exposure in comparison to an acute exposure. In general, for any cancer site, estimates of the dose-rate effectiveness factor (DDREF) generated by comparing the results for A-bomb survivors with those for the TB fluoroscopy cohorts should probably be roughly doubled from their apparent values because of the increased RBE of the fluoroscopy X rays.

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Comment in

• Risks for radiation-induced breast cancer: the debate continues.
  Ullrich RL. Ullrich RL. Radiat Res. 1999 Feb;151(2):123-4. Radiat Res. 1999. PMID: 9952295 No abstract available.
• Protraction of dose effects for radiogenic breast cancer.
  Rossi HH. Rossi HH. Radiat Res. 1999 Jul;152(1):104-5. Radiat Res. 1999. PMID: 10428682 No abstract available.
• Does repair of radiation damage play a role in breast cancer?
  Elkind MM. Elkind MM. Radiat Res. 1999 Nov;152(5):567. Radiat Res. 1999. PMID: 10577165 No abstract available.

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