Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta - PubMed (original) (raw)
Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta
R E Johnson et al. Science. 1999.
Abstract
The RAD30 gene of the yeast Saccharomyces cerevisiae is required for the error-free postreplicational repair of DNA that has been damaged by ultraviolet irradiation. Here, RAD30 is shown to encode a DNA polymerase that can replicate efficiently past a thymine-thymine cis-syn cyclobutane dimer, a lesion that normally blocks DNA polymerases. When incubated in vitro with all four nucleotides, Rad30 incorporates two adenines opposite the thymine-thymine dimer. Rad30 is the seventh eukaryotic DNA polymerase to be described and hence is named DNA polymerase eta.
Similar articles
- Thymine-thymine dimer bypass by yeast DNA polymerase zeta.
Nelson JR, Lawrence CW, Hinkle DC. Nelson JR, et al. Science. 1996 Jun 14;272(5268):1646-9. doi: 10.1126/science.272.5268.1646. Science. 1996. PMID: 8658138 - Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase eta.
Washington MT, Prakash L, Prakash S. Washington MT, et al. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12093-8. doi: 10.1073/pnas.2134223100. Epub 2003 Oct 3. Proc Natl Acad Sci U S A. 2003. PMID: 14527996 Free PMC article. - Yeast pol eta holds a cis-syn thymine dimer loosely in the active site during elongation opposite the 3'-T of the dimer, but tightly opposite the 5'-T.
Sun L, Zhang K, Zhou L, Hohler P, Kool ET, Yuan F, Wang Z, Taylor JS. Sun L, et al. Biochemistry. 2003 Aug 12;42(31):9431-7. doi: 10.1021/bi0345687. Biochemistry. 2003. PMID: 12899630 - poliota-dependent lesion bypass in vitro.
Vaisman A, Frank EG, McDonald JP, Tissier A, Woodgate R. Vaisman A, et al. Mutat Res. 2002 Dec 29;510(1-2):9-22. doi: 10.1016/s0027-5107(02)00248-8. Mutat Res. 2002. PMID: 12459439 Review. - DNA polymerase eta and chemotherapeutic agents.
Chou KM. Chou KM. Antioxid Redox Signal. 2011 Jun 15;14(12):2521-9. doi: 10.1089/ars.2010.3673. Epub 2011 Mar 18. Antioxid Redox Signal. 2011. PMID: 21050139 Free PMC article. Review.
Cited by
- Catalytic and noncatalytic functions of DNA polymerase κ in translesion DNA synthesis.
Sellés-Baiget S, Ambjørn SM, Carli A, Hendriks IA, Gallina I, Davey NE, Benedict B, Zarantonello A, Gadi SA, Meeusen B, Hertz EPT, Slappendel L, Semlow D, Sturla S, Nielsen ML, Nilsson J, Miller TCR, Duxin JP. Sellés-Baiget S, et al. Nat Struct Mol Biol. 2024 Sep 19. doi: 10.1038/s41594-024-01395-3. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 39300172 - Protein Assemblies in Translesion Synthesis.
Arianna GA, Korzhnev DM. Arianna GA, et al. Genes (Basel). 2024 Jun 24;15(7):832. doi: 10.3390/genes15070832. Genes (Basel). 2024. PMID: 39062611 Free PMC article. Review. - WRN exonuclease imparts high fidelity on translesion synthesis by Y family DNA polymerases.
Yoon JH, Sellamuthu K, Prakash L, Prakash S. Yoon JH, et al. Genes Dev. 2024 Apr 17;38(5-6):213-232. doi: 10.1101/gad.351410.123. Genes Dev. 2024. PMID: 38503516 Free PMC article. - High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma.
Duan M, Song S, Wasserman H, Lee PH, Liu KJ, Gordân R, He Y, Mao P. Duan M, et al. Proc Natl Acad Sci U S A. 2024 Jan 23;121(4):e2310854121. doi: 10.1073/pnas.2310854121. Epub 2024 Jan 19. Proc Natl Acad Sci U S A. 2024. PMID: 38241433 Free PMC article. - For the Better or for the Worse? The Effect of Manganese on the Activity of Eukaryotic DNA Polymerases.
Balint E, Unk I. Balint E, et al. Int J Mol Sci. 2023 Dec 27;25(1):363. doi: 10.3390/ijms25010363. Int J Mol Sci. 2023. PMID: 38203535 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Molecular Biology Databases
Miscellaneous