Geórgia Silva | PUC Minas (original) (raw)

Papers by Geórgia Silva

Research paper thumbnail of of Measure Driven Impulsive Systems

Research paper thumbnail of Clinical Usefulness of Electrophysiologic Testing in Patients with Ventricular Tachycardia and Chronic Chagasic Cardiomyopathy Treated with Amiodarone or Sotalol

Journal of Cardiovascular Electrophysiology, 2003

Introduction: This study assessed the role of electrophysiologic testing to identify therapeutic ... more Introduction: This study assessed the role of electrophysiologic testing to identify therapeutic strategies for the treatment of patients with sustained ventricular tachycardia (VT) and chronic chagasic cardiomyopathy treated with amiodarone or sotalol.Methods and Results: One hundred fifteen patients [69 men (60%); mean age52 ± 10years] with chagasic cardiomyopathy presenting with symptomatic VT were studied after loading with Class III antiarrhythmic drugs; 78 had a history of sustained VT, and 37 with symptomatic nonsustained VT had sustained VT induced at baseline electrophysiologic study. All but 12 patients also underwent baseline electrophysiologic study. Mean left ventricular ejection fraction was0.49 ± 0.14. Based on results of electrophysiologic study after loading with Class III drugs, patients were divided into three groups: group 1(n = 23)had no sustained VT induced; group 2(n = 45)had only tolerated sustained VT induced; and group 3(n = 47)had hemodynamically unstable sustained VT induced. After a mean follow-up of52 ± 32months, total mortality rate was 39.1%; it was significantly higher in group 3 than in groups 2 and 1 [69%, 22.2%, and 26%, respectively, P < 0.0001, hazard ratio (HR) 10.4, 95% confidence interval (CI) 3.8, 21.8]. There was no significant difference in total mortality rate between groups 1 and 2 (P = 0.40, HR 1.5, 95% CI 0.75, 4.58). Cardiac mortality and sudden cardiac death rates also were higher in group 3 patients.Conclusion: In patients with chagasic cardiomyopathy and sustained VT, electrophysiologic testing can predict long-term efficacy of Class III antiarrhythmic drugs. This may help in the selection of patients for implantable cardioverter defibrillator therapy. (J Cardiovasc Electrophysiol, Vol. 14, pp. 567-573, June 2003)

Research paper thumbnail of Leucemia Mielóide Agura: perfil de duas décadas do Serviço de Hematologia do Hospital das Clínicas de Porto Alegre - RS

Revista Brasileira De Hematologia E Hemoterapia, 2003

We have treated many AML patients in the last 20 years. We followed, between March 1980 and Decem... more We have treated many AML patients in the last 20 years. We followed, between March 1980 and December 1999, 195 patients with ages ranging from 12 to 70 years and presenting "de novo" AML, excluding the M3 subtype. In the eighties, 102 patients are on record: 47 males and 55 females. Among these, 84 received induction chemotherapy with Cytarabin plus Daunorrubicin (7+3), resulting in a 51% (43/84) remission rate. The average disease-free and overall survival was 35% at 10 months and 13% at 12 months. Forty-one new diagnoses were performed from January 1990 and December 1993, all patients were submitted to the "7+3" chemotherapy protocol and a 66% remission rate was obtained. The disease free and overall survival rates were statistically (p < 0.001) higher with 41% of the patients at 7.6 months and 17.5% at 22 months. In 1994 a new protocol was introduced under the guidance of the Brazilian Cooperative Group on Leukemia Studies (GCBEL). It recommended induction with Cytarabin + Idarrubicin followed by consolidation and two intensification cycles with high doses of Cytarabin. Between 1994 and 1999, 52 patients were included in this new protocol and the remission rate was 73% (p = 0.002). In 50% of these patients disease free survival was about 23.3 months, while the overall survival was 25% at 26 months. Both disease free survival and overall survival rates in the last period showed statistically significant differences when compared to the previous years. We observed a progressive improvement in remission and survival rates in the last decades, however the prolonged event-free survival stayed below 30%. Our results are similar to the national centers that treat AML and in accordance with the literature data.

Research paper thumbnail of Leucemia Mielóide Aguda: perfil de duas décadas do Serviço de Hematologia do Hospital de Clínicas de Porto Alegre - RS Acute Myelogenous Leukemia: two decades overview - Hematology Service Hospital de Clínicas de Porto Alegre RS

Research paper thumbnail of O homem na atenção primária à saúde: discutindo (in)visibilidade a partir da perspectiva de gênero

This paper presents an ethnographic study on the relationship between men and primary healthcare ... more This paper presents an ethnographic study on the relationship between men and primary healthcare in eight clinics in four Brazilian states. The objective was to comprehend the (in)visibility of men within the daily routine of care, based on gender perspectives, with discussion of the mechanisms that favor inequalities in healthcare work. Different dimensions of male (in)visibility were identified within this context: targeting of men in interventions within the field of public healthcare policies; male users who face difficulties in seeking attendance; difficulty in stimulating effective participation among men; and male subjects of care (for themselves and for others). The paper emphasizes the importance of gender studies and their relationship with health, while discussing the production of social inequalities that are (re)produced by the gender inequalities that are present in the social imaginary and in healthcare services.

Research paper thumbnail of of Measure Driven Impulsive Systems

Research paper thumbnail of Clinical Usefulness of Electrophysiologic Testing in Patients with Ventricular Tachycardia and Chronic Chagasic Cardiomyopathy Treated with Amiodarone or Sotalol

Journal of Cardiovascular Electrophysiology, 2003

Introduction: This study assessed the role of electrophysiologic testing to identify therapeutic ... more Introduction: This study assessed the role of electrophysiologic testing to identify therapeutic strategies for the treatment of patients with sustained ventricular tachycardia (VT) and chronic chagasic cardiomyopathy treated with amiodarone or sotalol.Methods and Results: One hundred fifteen patients [69 men (60%); mean age52 ± 10years] with chagasic cardiomyopathy presenting with symptomatic VT were studied after loading with Class III antiarrhythmic drugs; 78 had a history of sustained VT, and 37 with symptomatic nonsustained VT had sustained VT induced at baseline electrophysiologic study. All but 12 patients also underwent baseline electrophysiologic study. Mean left ventricular ejection fraction was0.49 ± 0.14. Based on results of electrophysiologic study after loading with Class III drugs, patients were divided into three groups: group 1(n = 23)had no sustained VT induced; group 2(n = 45)had only tolerated sustained VT induced; and group 3(n = 47)had hemodynamically unstable sustained VT induced. After a mean follow-up of52 ± 32months, total mortality rate was 39.1%; it was significantly higher in group 3 than in groups 2 and 1 [69%, 22.2%, and 26%, respectively, P < 0.0001, hazard ratio (HR) 10.4, 95% confidence interval (CI) 3.8, 21.8]. There was no significant difference in total mortality rate between groups 1 and 2 (P = 0.40, HR 1.5, 95% CI 0.75, 4.58). Cardiac mortality and sudden cardiac death rates also were higher in group 3 patients.Conclusion: In patients with chagasic cardiomyopathy and sustained VT, electrophysiologic testing can predict long-term efficacy of Class III antiarrhythmic drugs. This may help in the selection of patients for implantable cardioverter defibrillator therapy. (J Cardiovasc Electrophysiol, Vol. 14, pp. 567-573, June 2003)

Research paper thumbnail of Leucemia Mielóide Agura: perfil de duas décadas do Serviço de Hematologia do Hospital das Clínicas de Porto Alegre - RS

Revista Brasileira De Hematologia E Hemoterapia, 2003

We have treated many AML patients in the last 20 years. We followed, between March 1980 and Decem... more We have treated many AML patients in the last 20 years. We followed, between March 1980 and December 1999, 195 patients with ages ranging from 12 to 70 years and presenting "de novo" AML, excluding the M3 subtype. In the eighties, 102 patients are on record: 47 males and 55 females. Among these, 84 received induction chemotherapy with Cytarabin plus Daunorrubicin (7+3), resulting in a 51% (43/84) remission rate. The average disease-free and overall survival was 35% at 10 months and 13% at 12 months. Forty-one new diagnoses were performed from January 1990 and December 1993, all patients were submitted to the "7+3" chemotherapy protocol and a 66% remission rate was obtained. The disease free and overall survival rates were statistically (p < 0.001) higher with 41% of the patients at 7.6 months and 17.5% at 22 months. In 1994 a new protocol was introduced under the guidance of the Brazilian Cooperative Group on Leukemia Studies (GCBEL). It recommended induction with Cytarabin + Idarrubicin followed by consolidation and two intensification cycles with high doses of Cytarabin. Between 1994 and 1999, 52 patients were included in this new protocol and the remission rate was 73% (p = 0.002). In 50% of these patients disease free survival was about 23.3 months, while the overall survival was 25% at 26 months. Both disease free survival and overall survival rates in the last period showed statistically significant differences when compared to the previous years. We observed a progressive improvement in remission and survival rates in the last decades, however the prolonged event-free survival stayed below 30%. Our results are similar to the national centers that treat AML and in accordance with the literature data.

Research paper thumbnail of Leucemia Mielóide Aguda: perfil de duas décadas do Serviço de Hematologia do Hospital de Clínicas de Porto Alegre - RS Acute Myelogenous Leukemia: two decades overview - Hematology Service Hospital de Clínicas de Porto Alegre RS

Research paper thumbnail of O homem na atenção primária à saúde: discutindo (in)visibilidade a partir da perspectiva de gênero

This paper presents an ethnographic study on the relationship between men and primary healthcare ... more This paper presents an ethnographic study on the relationship between men and primary healthcare in eight clinics in four Brazilian states. The objective was to comprehend the (in)visibility of men within the daily routine of care, based on gender perspectives, with discussion of the mechanisms that favor inequalities in healthcare work. Different dimensions of male (in)visibility were identified within this context: targeting of men in interventions within the field of public healthcare policies; male users who face difficulties in seeking attendance; difficulty in stimulating effective participation among men; and male subjects of care (for themselves and for others). The paper emphasizes the importance of gender studies and their relationship with health, while discussing the production of social inequalities that are (re)produced by the gender inequalities that are present in the social imaginary and in healthcare services.