Dr Kiran S H A F I Q Ahmed | University of the Punjab, Lahore, Pakistan (original) (raw)

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Papers by Dr Kiran S H A F I Q Ahmed

Russian open medical journal, Mar 25, 2024

Background-Type 1 diabetes mellitus causes serious disease complication in children. Objectives-T... more Background-Type 1 diabetes mellitus causes serious disease complication in children. Objectives-The main objective of this study was to assess the frequency and severity of diabetic complication in children ≤ 20 years of age from Punjab, Pakistan. Methods-The data of diabetic patients and their blood samples were collected from the diabetic registries at three districts of Punjab, Pakistan. Fasting plasma glucose, random plasma glucose, HbA1c, and GAD-65 autoantibodies were measured in sampled blood serum. The data on other clinical symptoms at the onset of disease were recorded as well. Results-Out of 310 patients, 54.2% were male, and their mean age at the onset of disease was 13.22 years. Among all patients, according to clinical indicators, high severity of the disease and serious complications were revealed. Conclusions-The diabetic complications were severe in all patients from three districts of Punjab, Pakistan, at and below the age of 20 years.

Accumulation of selected heavy metals (Cd, Cr, Cu, Fe & Pb) was assessed in cape hare (Lepus cape... more Accumulation of selected heavy metals (Cd, Cr, Cu, Fe & Pb) was assessed in cape hare (Lepus capensis) from northern areas of Pakistan. Five different tissues (heart, lungs, kidneys, liver and muscles) of twelve males and nine females were studied for metal accumulation. A significant variation of heavy metals concentration was observed among different tissues of cape hare. The mean concentration of Cd was highest in heart (1.688 μg/g) and lowest in muscles (1.27 μg/g) and Cr in heart (86.6 μg/g) was highest and in the lungs (5.2 μg/g) was the lowest. Cu in liver (3.96 μg/g) was highest and lowest in lungs (2.793 μg/g) and Fe had highest value in lungs (154.9 μg/g) as compared to muscle (59.57 μg/g). While Pb was highest in lungs (40.31μg/g), minimum in kidneys (19.68 μg/g) and In relation to sex, higher mean concentration of heavy metals was observed in female as compared to male except Cr. It was found in all the tissues of males but not detected in the lungs, liver and muscles of...

Saudi Journal of Biological Sciences, 2021

Carcinogenic and health hazard causing heavy metals have been increasing in our dietary stuffs du... more Carcinogenic and health hazard causing heavy metals have been increasing in our dietary stuffs due to large amount of industrial effluents being dumped in water bodies that are ultimately used for irrigation purposes. The study was aimed to assess and compare the mean concentrations of heavy metals (Cd, As and Pb) in soil and vegetables irrigated with four different sources (Ground water, river water, domestic sewage water and industrial untreated effluents and domestic waste water receiving drains) for the estimation of carcinogenic and non-carcinogenic health risk associated with them. Prepared samples were analyzed by through ICP-OES. Statistical analysis revealed that domestic sewage water and drains water usage for irrigation purposes leads to high values of Estimated Daily Intake (EDI) of metals through vegetation. To assess the carcinogenic effects values daily intakes, Total hazard quotients (THQs) and Health indexes (HI), while for carcinogenic effects, Total cancer risks (TCR) were determined. The results of present study revealed that the daily intakes of these metals are far less than that of permissible levels but their bio-accumulating behavior produce high risks to human health. The HI values revealed that waste water usage is producing the vegetables of high health risks. In adults, the HI of Phaseolus vulgaris, Spinacia oleracea, Brassica compestris, Raphnus sativus, Daucus carota and Solanum tuberosum assessed as 0.81, 1.52, 1.26, 0.12, 0.22, and 0.15 (ground water irrigation), 0.046, 0.75, 0.51, 0.68, 0.90 0.064 (River Ravi water irrigation), 1.23, 3.34, 4.81, 4.23, 1.41 and 3.43 (domestic sewage irrigation) and 3.04, 5.50, 6.08, 2.50, 5.34 and 5.13 (Drain waste water irrigation), respectively. It was observed that cancer risks of As exceeded the threshold (1 × 10−4) in all i.e. ground river, domestic sewage and drain water grown vegetables, while, Cd and Pb were in permissible range.

The Egyptian Journal of Aquatic Research, 2020

The Best Practice & Research series aims to provide a topical serial publication describing and i... more The Best Practice & Research series aims to provide a topical serial publication describing and integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.

Saudi Journal of Biological Sciences, 2022

Contamination of food chain by Polychlorinated biphenyls through use of pesticides, electric and ... more Contamination of food chain by Polychlorinated biphenyls through use of pesticides, electric and industrial waste poses human health risk. In previous studies, PCB species were stated as endocrine disrupting pollutants and showed toxic health effects like cancerous and noncancerous in animals. The aim of this study was to investigate the levels of PCBs and its toxicity equivalence in food item from plant source to evaluate the health risk in Khanewal and Multan, Pakistan. Samples were collected and processed for further analysis of PCB species through GC/MS after extraction and clean up. The mean concentrations of PCBs ranged as 2.71-151.67 ng/g in beans and grains and 2.30-97.00 ng/g dry weight in vegetables and were lower than 200-3000 ng/g PCBs recommended by FDA tolerance level for all foods. The mean concentrations of two NDL-PCB species detected in all vegetables, beans and grains except S.indicum and T.aestivum were lower than maximum allowable concentration of non-dioxin like PCBs i.e. 40ngg À1 reported by European Commission. Mean TEQ of sum of 14 PCB species ranged as 1.52-5.91 ng-WHO-TEQg À1 in vegetables and 1.46-10.04 ng-WHO-TEQg À1 in beans and grains. The present study concluded that the mean concentrations and mean TEQs of PCB species in most of the vegetables, beans and grains were found safe but due to higher consumption rate of some vegetables and grains, posed the moderate level of risk for human health. This study emphasizes on an implement of the strict rules regarding the use of restricted chemicals to diminish the effluence in food chains. Current research will be useful in up gradation of effective measures to reduce the poisonous contribution of PCB sources and the sustainability of terrestrial ecosystem in the country.

Russian open medical journal, Mar 25, 2024

Background-Type 1 diabetes mellitus causes serious disease complication in children. Objectives-T... more Background-Type 1 diabetes mellitus causes serious disease complication in children. Objectives-The main objective of this study was to assess the frequency and severity of diabetic complication in children ≤ 20 years of age from Punjab, Pakistan. Methods-The data of diabetic patients and their blood samples were collected from the diabetic registries at three districts of Punjab, Pakistan. Fasting plasma glucose, random plasma glucose, HbA1c, and GAD-65 autoantibodies were measured in sampled blood serum. The data on other clinical symptoms at the onset of disease were recorded as well. Results-Out of 310 patients, 54.2% were male, and their mean age at the onset of disease was 13.22 years. Among all patients, according to clinical indicators, high severity of the disease and serious complications were revealed. Conclusions-The diabetic complications were severe in all patients from three districts of Punjab, Pakistan, at and below the age of 20 years.

Accumulation of selected heavy metals (Cd, Cr, Cu, Fe & Pb) was assessed in cape hare (Lepus cape... more Accumulation of selected heavy metals (Cd, Cr, Cu, Fe & Pb) was assessed in cape hare (Lepus capensis) from northern areas of Pakistan. Five different tissues (heart, lungs, kidneys, liver and muscles) of twelve males and nine females were studied for metal accumulation. A significant variation of heavy metals concentration was observed among different tissues of cape hare. The mean concentration of Cd was highest in heart (1.688 μg/g) and lowest in muscles (1.27 μg/g) and Cr in heart (86.6 μg/g) was highest and in the lungs (5.2 μg/g) was the lowest. Cu in liver (3.96 μg/g) was highest and lowest in lungs (2.793 μg/g) and Fe had highest value in lungs (154.9 μg/g) as compared to muscle (59.57 μg/g). While Pb was highest in lungs (40.31μg/g), minimum in kidneys (19.68 μg/g) and In relation to sex, higher mean concentration of heavy metals was observed in female as compared to male except Cr. It was found in all the tissues of males but not detected in the lungs, liver and muscles of...

Saudi Journal of Biological Sciences, 2021

Carcinogenic and health hazard causing heavy metals have been increasing in our dietary stuffs du... more Carcinogenic and health hazard causing heavy metals have been increasing in our dietary stuffs due to large amount of industrial effluents being dumped in water bodies that are ultimately used for irrigation purposes. The study was aimed to assess and compare the mean concentrations of heavy metals (Cd, As and Pb) in soil and vegetables irrigated with four different sources (Ground water, river water, domestic sewage water and industrial untreated effluents and domestic waste water receiving drains) for the estimation of carcinogenic and non-carcinogenic health risk associated with them. Prepared samples were analyzed by through ICP-OES. Statistical analysis revealed that domestic sewage water and drains water usage for irrigation purposes leads to high values of Estimated Daily Intake (EDI) of metals through vegetation. To assess the carcinogenic effects values daily intakes, Total hazard quotients (THQs) and Health indexes (HI), while for carcinogenic effects, Total cancer risks (TCR) were determined. The results of present study revealed that the daily intakes of these metals are far less than that of permissible levels but their bio-accumulating behavior produce high risks to human health. The HI values revealed that waste water usage is producing the vegetables of high health risks. In adults, the HI of Phaseolus vulgaris, Spinacia oleracea, Brassica compestris, Raphnus sativus, Daucus carota and Solanum tuberosum assessed as 0.81, 1.52, 1.26, 0.12, 0.22, and 0.15 (ground water irrigation), 0.046, 0.75, 0.51, 0.68, 0.90 0.064 (River Ravi water irrigation), 1.23, 3.34, 4.81, 4.23, 1.41 and 3.43 (domestic sewage irrigation) and 3.04, 5.50, 6.08, 2.50, 5.34 and 5.13 (Drain waste water irrigation), respectively. It was observed that cancer risks of As exceeded the threshold (1 × 10−4) in all i.e. ground river, domestic sewage and drain water grown vegetables, while, Cd and Pb were in permissible range.

The Egyptian Journal of Aquatic Research, 2020

The Best Practice & Research series aims to provide a topical serial publication describing and i... more The Best Practice & Research series aims to provide a topical serial publication describing and integrating the results from the latest original research articles into practical, evidence-based review articles. These articles seek to address the key clinical issues of diagnosis, treatment and patient management. Each issue follows a problem-orientated approach which focuses on the key questions to be addressed, clearly defining what is known and not known. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.

Saudi Journal of Biological Sciences, 2022

Contamination of food chain by Polychlorinated biphenyls through use of pesticides, electric and ... more Contamination of food chain by Polychlorinated biphenyls through use of pesticides, electric and industrial waste poses human health risk. In previous studies, PCB species were stated as endocrine disrupting pollutants and showed toxic health effects like cancerous and noncancerous in animals. The aim of this study was to investigate the levels of PCBs and its toxicity equivalence in food item from plant source to evaluate the health risk in Khanewal and Multan, Pakistan. Samples were collected and processed for further analysis of PCB species through GC/MS after extraction and clean up. The mean concentrations of PCBs ranged as 2.71-151.67 ng/g in beans and grains and 2.30-97.00 ng/g dry weight in vegetables and were lower than 200-3000 ng/g PCBs recommended by FDA tolerance level for all foods. The mean concentrations of two NDL-PCB species detected in all vegetables, beans and grains except S.indicum and T.aestivum were lower than maximum allowable concentration of non-dioxin like PCBs i.e. 40ngg À1 reported by European Commission. Mean TEQ of sum of 14 PCB species ranged as 1.52-5.91 ng-WHO-TEQg À1 in vegetables and 1.46-10.04 ng-WHO-TEQg À1 in beans and grains. The present study concluded that the mean concentrations and mean TEQs of PCB species in most of the vegetables, beans and grains were found safe but due to higher consumption rate of some vegetables and grains, posed the moderate level of risk for human health. This study emphasizes on an implement of the strict rules regarding the use of restricted chemicals to diminish the effluence in food chains. Current research will be useful in up gradation of effective measures to reduce the poisonous contribution of PCB sources and the sustainability of terrestrial ecosystem in the country.