Gul Majid Khan | Quaid-i-Azam University, Islamabad, Pakistan (original) (raw)
•> 34-years extensive Teaching, Research experience with in the Country and abroad in several Western as well as Eastern Countries along with vast experience in the areas of planning
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Papers by Gul Majid Khan
Public health, Jan 8, 2017
Journal of Medical Sciences(Faisalabad), 2001
Journal of Clinical Pathology, 1994
Abstract: Introduction: Thiomers are the product of the immobilization of sulfhydryl-bearing lig... more Abstract:
Introduction: Thiomers are the product of the immobilization of sulfhydryl-bearing ligands onto the polymer backbone of a conventional polymer, which results in a significant improvement in mucoadhesion; in situ gelation and efflux inhibition compare with unchanged polymers. Because of thiol groups, thiomers have more reactivity and enhanced protection against oxidation. Since the late 1990s, extensive work has been conducted on these promising polymeric excipients in the pharmaceutical field.
Areas Covered: This review covers thiomers, their classification and their different properties. Various techniques for the synthesis, purification and characterization of thiomers are described in detail. This review also encompasses their various properties such as mucoadhesion, permeation enhancement, in situ gelation and efflux inhibition, as well as different formulations based on thiomers. In addition to the use of thiomers as multifunctional excipients, this review also encompasses their use as drugs.
Expert Opinion: The synthesis is realized by linkage of sulfhydryl-bearing ligands but reported methods give low yields. Higher degrees of modification are not necessary and would probably lead to extreme changes in properties. Nevertheless, an accurate characterization of the final product is important. The scale-up procedure for industrial manufacturing has been adapted to produce GMP materials; Lacrimera® eye drops have already entered the European market.
Pakistan journal of pharmaceutical sciences, 2005
Coating has been widely used in pharmaceutical manufacture either as non-functional or a function... more Coating has been widely used in pharmaceutical manufacture either as non-functional or a functional entity. The objectives of the present study were to investigate the effect of plasticizers such as PEG400, PEG1000 and triacetin on mechanical properties, glass transition temperature and water vapor transmission of free films prepared from HPMC and/or HPMC:PVA blends, to develop suitable coating system for tablets, and to determine the release profiles of the coated tablets. The tensile strength of plasticized HPMC films was generally lower than that of control HPMC film and could be attributed to increased crystallinity and segmental chain mobility of HPMC. This effect increased as the concentration of plasticizer increased. Generally the addition of both grades of polyethylene glycol (PEG400 & PEG1000) increased the moisture permeability of HPMC films but the films containing triacetin provided a more rigid barrier to moisture compared to unplasticized HPMC films. The dissolution p...
Journal of Medical Sciences(Faisalabad), 2001
ABSTRACT The effects of tetrakis-?-3,5-di-isopropyl Salicylatodiaquodicopper (II) (3,5-DIPS)4 (H2... more ABSTRACT The effects of tetrakis-?-3,5-di-isopropyl Salicylatodiaquodicopper (II) (3,5-DIPS)4 (H2O)2 and sodium gold (I) thiomalate (Myocrisin) Au(I) (S-CHCH2(CO2)2Na2 on the metabolism of plasma thiol in volunteer human blood and/or rheumatoid arthritis (RA) patients phase-I were compared and examined. Human blood and/or plasma was incubated with Cu (II) (3,5-DIPS)4 (H2O)2. Plasma thiol was measured by spectrophotometer using Ellman`s reagent for derivatization. Myocrisin was administered to RA patients in phase-I and blood was collected for plasma thiol determination using Ellman`s method. Both copper and gold complexes and/or drugs increased the concentrations of plasma thiol as compared to control group and/or in RA patients. Both copper and gold were found to have the potential to enhance the release of thiol from plasma by affecting the exposure of hidden thiol, contained in plasma proteins and enzymes. These results suggested that these complexes and/or drugs perhaps caused the leakage of the hidden plasma thiols present in proteins and enzymes preferably on albumin, a major thiol containing protein in plasma. This alteration in plasma thiol concentration in blood and/or plasma by copper and gold complex and/or drug may count towards their some pharmacological effects.
Pakistan Journal of Biological Sciences, 2002
Heteroatom Chemistry, 2007
Advanced Powder Technology, 2011
In the present study, a modified 4-fluid nozzle spray drier was used to prepare microparticles of... more In the present study, a modified 4-fluid nozzle spray drier was used to prepare microparticles of a poorly water soluble drug, artemisinin with the aim of improving its solubility. We also investigated the effect of process variables on the physical properties and dissolution rate of spray dried artemisinin. A full factorial experimentally designed study was performed to investigate the following
Public health, Jan 8, 2017
Journal of Medical Sciences(Faisalabad), 2001
Journal of Clinical Pathology, 1994
Abstract: Introduction: Thiomers are the product of the immobilization of sulfhydryl-bearing lig... more Abstract:
Introduction: Thiomers are the product of the immobilization of sulfhydryl-bearing ligands onto the polymer backbone of a conventional polymer, which results in a significant improvement in mucoadhesion; in situ gelation and efflux inhibition compare with unchanged polymers. Because of thiol groups, thiomers have more reactivity and enhanced protection against oxidation. Since the late 1990s, extensive work has been conducted on these promising polymeric excipients in the pharmaceutical field.
Areas Covered: This review covers thiomers, their classification and their different properties. Various techniques for the synthesis, purification and characterization of thiomers are described in detail. This review also encompasses their various properties such as mucoadhesion, permeation enhancement, in situ gelation and efflux inhibition, as well as different formulations based on thiomers. In addition to the use of thiomers as multifunctional excipients, this review also encompasses their use as drugs.
Expert Opinion: The synthesis is realized by linkage of sulfhydryl-bearing ligands but reported methods give low yields. Higher degrees of modification are not necessary and would probably lead to extreme changes in properties. Nevertheless, an accurate characterization of the final product is important. The scale-up procedure for industrial manufacturing has been adapted to produce GMP materials; Lacrimera® eye drops have already entered the European market.
Pakistan journal of pharmaceutical sciences, 2005
Coating has been widely used in pharmaceutical manufacture either as non-functional or a function... more Coating has been widely used in pharmaceutical manufacture either as non-functional or a functional entity. The objectives of the present study were to investigate the effect of plasticizers such as PEG400, PEG1000 and triacetin on mechanical properties, glass transition temperature and water vapor transmission of free films prepared from HPMC and/or HPMC:PVA blends, to develop suitable coating system for tablets, and to determine the release profiles of the coated tablets. The tensile strength of plasticized HPMC films was generally lower than that of control HPMC film and could be attributed to increased crystallinity and segmental chain mobility of HPMC. This effect increased as the concentration of plasticizer increased. Generally the addition of both grades of polyethylene glycol (PEG400 & PEG1000) increased the moisture permeability of HPMC films but the films containing triacetin provided a more rigid barrier to moisture compared to unplasticized HPMC films. The dissolution p...
Journal of Medical Sciences(Faisalabad), 2001
ABSTRACT The effects of tetrakis-?-3,5-di-isopropyl Salicylatodiaquodicopper (II) (3,5-DIPS)4 (H2... more ABSTRACT The effects of tetrakis-?-3,5-di-isopropyl Salicylatodiaquodicopper (II) (3,5-DIPS)4 (H2O)2 and sodium gold (I) thiomalate (Myocrisin) Au(I) (S-CHCH2(CO2)2Na2 on the metabolism of plasma thiol in volunteer human blood and/or rheumatoid arthritis (RA) patients phase-I were compared and examined. Human blood and/or plasma was incubated with Cu (II) (3,5-DIPS)4 (H2O)2. Plasma thiol was measured by spectrophotometer using Ellman`s reagent for derivatization. Myocrisin was administered to RA patients in phase-I and blood was collected for plasma thiol determination using Ellman`s method. Both copper and gold complexes and/or drugs increased the concentrations of plasma thiol as compared to control group and/or in RA patients. Both copper and gold were found to have the potential to enhance the release of thiol from plasma by affecting the exposure of hidden thiol, contained in plasma proteins and enzymes. These results suggested that these complexes and/or drugs perhaps caused the leakage of the hidden plasma thiols present in proteins and enzymes preferably on albumin, a major thiol containing protein in plasma. This alteration in plasma thiol concentration in blood and/or plasma by copper and gold complex and/or drug may count towards their some pharmacological effects.
Pakistan Journal of Biological Sciences, 2002
Heteroatom Chemistry, 2007
Advanced Powder Technology, 2011
In the present study, a modified 4-fluid nozzle spray drier was used to prepare microparticles of... more In the present study, a modified 4-fluid nozzle spray drier was used to prepare microparticles of a poorly water soluble drug, artemisinin with the aim of improving its solubility. We also investigated the effect of process variables on the physical properties and dissolution rate of spray dried artemisinin. A full factorial experimentally designed study was performed to investigate the following
CV, 2020
GM Khan CV & List of Publications 2020a
GM Khan CV & List of Publications, 2020
GM Khan CV & List of Publications
Curriculum Vitae, 2021
Curriculum Vitae and List of Publications of Prof. Dr. Gul Majid Khan, Vice Chancellor: Islamia C... more Curriculum Vitae and List of Publications of Prof. Dr. Gul Majid Khan, Vice Chancellor: Islamia College University, Peshawar & Tenured Professor: Department of Pharmacy, Quaid-i-Azam University, Islamabad