Satyajit Bhattacharya | Queen Mary, University of London (original) (raw)
Papers by Satyajit Bhattacharya
8th European Congress of Endocrinology incorporating the British Endocrine Societies, Dec 4, 2006
PubMed, 1995
Arterially administered iodized oil (Lipiodol) localizes selectively in HCCs for prolonged period... more Arterially administered iodized oil (Lipiodol) localizes selectively in HCCs for prolonged periods. Lipiodol-based intra-arterial chemotherapy and chemoembolization have yielded tumor response rates and survival benefits better than those offered by other therapies for unresectable Okuda Stage I and II HCC. Further trials are indicated to compare the different Lipiodol-cytotoxic-embolic regimens available. Early results of Lipiodol-targeted radiotherapy are available. This is a promising therapeutic development, and warrants comparison with chemoembolization in a large prospective randomized trial.
British Journal of Surgery, Nov 1, 1994
Pancreatology, Mar 1, 2017
Polymeric immunoglobulin receptor (pIgR) traffics Immunoglobulins (IgA and IgM) through epithelia... more Polymeric immunoglobulin receptor (pIgR) traffics Immunoglobulins (IgA and IgM) through epithelial cells in normal mucosae but neither are expressed in the normal pancreas. Recent work from our laboratory suggested pIgR may be upregulated in pancreatic ductal adenocarcinoma (PDAC). Our aim was to assess the role of pIgR in human PDAC. pIgR expression was manipulated (siRNA and shRNA) in cell lines to evaluate its subsequent effect on cell behaviour in 2D assays as well as 3D organotypics models. Tissue Microarrays of 88 patients with PDAC were analysed after pIgR, αSMA, E-Cadherin and Picrosirius Red staining to assess their role as a combined bio-marker panel. Cytokines such as interleukin 4 (IL4) and Tumour Necrosis Factor (TNFα) could not modulate pIgR expression in PDAC cell lines despite this effect being seen in other studies. Down-regulation in pIgR expression in Capan1 cancer cell line resulted in reduction of cellular proliferation, adhesion and migration in 2D assays. In 3D physiomimetic organotypic models, pIgR downregulation resulted in reduced cancer cell invasion, alteration of apico-basal polarity and diminished stromal activity. In human PDAC, decreased E-cadherin expression correlates with increased pIgR expression through pancreatic intra-epithelial neoplasia (PanIN) progression. In combination with enhanced stromal indices (α-smooth muscle action (SMA) and Picrosirius red), low pIgR scores had a trend towards better survival. pIgR may be involved in PDAC progression and may be linked stromal activity. Further work on its precise role is mandated in in vivo models, to understand its influence on cancer progression.
British Journal of Surgery, Feb 1, 1999
The National Medical Journal of India, Nov 1, 2022
The Journal of Pathology, Mar 21, 2013
Epithelial tissues have sparse stroma, in contrast to their corresponding tumours. The effect of ... more Epithelial tissues have sparse stroma, in contrast to their corresponding tumours. The effect of cancer cells on stromal cells is well recognized. Increasingly, stromal components, such as endothelial and immune cells, are considered indispensable for cancer progression. The role of
Journal of Hepatology, 1994
of 61 consecutive patients undergoing laparoscopic cholecystectomy, 4 (6.25) developed abdominal ... more of 61 consecutive patients undergoing laparoscopic cholecystectomy, 4 (6.25) developed abdominal wall haematomas. This complication of laparoscopic cholecystectomy may occur more commonly than existing literature suggests, and manifests in the post-operative period (days 2 to 6) by visible bruising, excessive pain or an asymptomatic drop in haematocrit. It is readily confirmed by ultrasonography. While no specific treatment is necessary apart from replacement of significant blood loss, the patient requires reassurance that this apparently alarming complication will rapidly resolve.
International Journal of Surgery, 2010
Annals of Surgery, May 1, 2016
![Research paper thumbnail of Corrigendum to “Expression of polymeric immunoglobulin receptor and stromal activity in pancreatic ductal adenocarcinoma” [Pancreatology 17 (2017) 295–302]](https://attachments.academia-assets.com/108061285/thumbnails/1.jpg)
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Trends in Urology & Men's Health
Pancreatic cancer carries a very poor prognosis, with five‐year survival currently approaching 10... more Pancreatic cancer carries a very poor prognosis, with five‐year survival currently approaching 10%. Late presentation, lack of effective treatment options and a tumour microenvironment that subverts immune mechanisms are some of the reasons behind this. Here the authors discuss how advances in our understanding of tumour biology, identification and surveillance of high‐risk groups, improvements in surgical outcomes and the availability of new chemotherapeutic options give us grounds for optimism.
European Journal of Endocrinology, 2010
ContextPreoperative localisation of insulinoma improves cure rate and reduces complications, but ... more ContextPreoperative localisation of insulinoma improves cure rate and reduces complications, but may be challenging.ObjectiveTo review diagnostic features and localisation accuracy for insulinomas.DesignCross-sectional, retrospective analysis.SettingA single tertiary referral centre.PatientsPatients with insulinoma in the years 1990–2009, including sporadic tumours and those in patients with multiple endocrine neoplasia syndromes.InterventionsPatients were identified from a database, and case notes and investigation results were reviewed. Tumour localisation by computed tomography (CT), magnetic resonance imaging (MRI), octreotide scanning, endoscopic ultrasound (EUS) and calcium stimulation was evaluated.Main outcome measure(s)Insulinoma localisation was compared to histologically confirmed location following surgical excision.ResultsThirty-seven instances of biochemically and/or histologically proven insulinoma were identified in 36 patients, of which seven were managed medically....
The Journal of Clinical Endocrinology & Metabolism, 2006
Background: Insulinomas are rare but are the most common cause of hyperinsulinemic hypoglycemia i... more Background: Insulinomas are rare but are the most common cause of hyperinsulinemic hypoglycemia in the adult population. Diagnosis of this pathology relies on clinical features along with laboratory tests and imaging investigations to aid in localization. One of the most robust standard tests used for establishing a biochemical diagnosis is the prolonged (72 h) fast. Currently, it is recommended that a prolonged supervised fast be performed, at least for 48 h if not for 72 h, and many would take the absence of hypoglycemia after a 72-h fast as evidence excluding the diagnosis. Methods: We employed prolonged fasts and standard glucose tolerance tests, plus imaging studies and surgical pathology, in two patients with suspected insulinomas. Results: The prolonged 72-h fast was normal in both the patients, whereas in both cases a prolonged oral glucose tolerance test clearly demonstrated the induction of severe hyperinsulinemia followed by significant hypoglycemia. Surgical removal conf...
Surgical Case Reports, 2021
Background: Major bile duct injuries (BDIs) are hazardous complications after laparoscopic cholec... more Background: Major bile duct injuries (BDIs) are hazardous complications after laparoscopic cholecystectomy (0.4%-0.6% of all laparoscopic cholecystectomies) [1, 2-4]. Major BDIs usually require surgery, ideally either within one week or after 3 three months after index surgery [1]. We describe the case of iatrogenic transection of the common bile duct (CBD) complicated by a complex full midline abdominal evisceration presented on day 12 after emergency laparotomy for biliary peritonitis. Case Presentation: A 65-year-old male underwent laparoscopic cholecystectomy in a district general hospital and was discharged on the same day, following apparently uneventful surgery. He, however, re-presented two days later with biliary peritonitis when emergency ERCP showed full CBD transection. The local surgical team performed midline exploratory laparotomy, washout, and external drainage aside the leaking CBD and referred the case to our tertiary HPB service. While awaiting transfer (due to be...
HPB, 2018
analysis, we compared the patients surviving more than 36 months after the operation, to the ones... more analysis, we compared the patients surviving more than 36 months after the operation, to the ones who did not reach this period. Biodemographic, clinical, histopathological and morbimortality data were compared between cases and controls using logistic regression. Results: Seventy patients were analyzed; mean age of 62, AE 11 years; 40 (57%) women. Mean and overall survival was 34 months and 22% at five years for the entire series. Mean resected lymph nodes was 18 AE 9. Twenty-one cases (30%) reached a survival greater than 36 months. At univariate analysis, R0 resection, the absence of positive lymph nodes, the absence of perineural infiltration and early stages (IA, IB and IIA) were associated with survival greater than 36 months (p < 0,05). After multivariable analysis, the absence of diabetes mellitus at the time of diagnosis (OR:12, 95% CI 1.7e84.3); the absence of perineural infiltration (OR: 7, 95% CI 1.3e36.3) and early stages (OR: 10, 05% CI 2.1e49.1) were demonstrated to be independent factors associated with survival greater than three years. Conclusion: Early stages of the disease, the absence of diabetes mellitus and no perineural infiltration at specimen were associated with survival greater than three years.
BMJ Open, 2016
Introduction: Remote video consultations between clinician and patient are technically possible a... more Introduction: Remote video consultations between clinician and patient are technically possible and increasingly acceptable. They are being introduced in some settings alongside (and occasionally replacing) face-to-face or telephone consultations. Methods: To explore the advantages and limitations of video consultations, we will conduct in-depth qualitative studies of real consultations (microlevel) embedded in an organisational case study (mesolevel), taking account of national context (macrolevel). The study is based in 2 contrasting clinical settings (diabetes and cancer) in a National Health Service (NHS) acute trust in London, UK. Main data sources are: microlevel-audio, video and screen capture to produce rich multimodal data on 45 remote consultations; mesolevel-interviews, ethnographic observations and analysis of documents within the trust; macrolevel-key informant interviews of national-level stakeholders and document analysis. Data will be analysed and synthesised using a sociotechnical framework developed from structuration theory.
European Journal of Surgical Oncology, 2018
, support, help and guidance during my internship and the last year of my PhD. I am thankful for ... more , support, help and guidance during my internship and the last year of my PhD. I am thankful for his guidance in our many discussions, as well as his genuine patience and positivity and his tireless effort in helping me move my career forward. I am forever grateful to have met him and worked with him. Finally, I would like to thank my family and friends whom I have probably not dedicated the amount of time they deserve, for their motivation and encouragement both in and out of the laboratory. To my parents, who supported me throughout my entire collegiate career; to my siblings who are and will always be my rock in daunting times; and to "My Person" Annie for being my daily sunshine and to the love of my life Karyll Hyacinthe, who motivated me to be the best engineer I can be. I thank you all.
8th European Congress of Endocrinology incorporating the British Endocrine Societies, Dec 4, 2006
PubMed, 1995
Arterially administered iodized oil (Lipiodol) localizes selectively in HCCs for prolonged period... more Arterially administered iodized oil (Lipiodol) localizes selectively in HCCs for prolonged periods. Lipiodol-based intra-arterial chemotherapy and chemoembolization have yielded tumor response rates and survival benefits better than those offered by other therapies for unresectable Okuda Stage I and II HCC. Further trials are indicated to compare the different Lipiodol-cytotoxic-embolic regimens available. Early results of Lipiodol-targeted radiotherapy are available. This is a promising therapeutic development, and warrants comparison with chemoembolization in a large prospective randomized trial.
British Journal of Surgery, Nov 1, 1994
Pancreatology, Mar 1, 2017
Polymeric immunoglobulin receptor (pIgR) traffics Immunoglobulins (IgA and IgM) through epithelia... more Polymeric immunoglobulin receptor (pIgR) traffics Immunoglobulins (IgA and IgM) through epithelial cells in normal mucosae but neither are expressed in the normal pancreas. Recent work from our laboratory suggested pIgR may be upregulated in pancreatic ductal adenocarcinoma (PDAC). Our aim was to assess the role of pIgR in human PDAC. pIgR expression was manipulated (siRNA and shRNA) in cell lines to evaluate its subsequent effect on cell behaviour in 2D assays as well as 3D organotypics models. Tissue Microarrays of 88 patients with PDAC were analysed after pIgR, αSMA, E-Cadherin and Picrosirius Red staining to assess their role as a combined bio-marker panel. Cytokines such as interleukin 4 (IL4) and Tumour Necrosis Factor (TNFα) could not modulate pIgR expression in PDAC cell lines despite this effect being seen in other studies. Down-regulation in pIgR expression in Capan1 cancer cell line resulted in reduction of cellular proliferation, adhesion and migration in 2D assays. In 3D physiomimetic organotypic models, pIgR downregulation resulted in reduced cancer cell invasion, alteration of apico-basal polarity and diminished stromal activity. In human PDAC, decreased E-cadherin expression correlates with increased pIgR expression through pancreatic intra-epithelial neoplasia (PanIN) progression. In combination with enhanced stromal indices (α-smooth muscle action (SMA) and Picrosirius red), low pIgR scores had a trend towards better survival. pIgR may be involved in PDAC progression and may be linked stromal activity. Further work on its precise role is mandated in in vivo models, to understand its influence on cancer progression.
British Journal of Surgery, Feb 1, 1999
The National Medical Journal of India, Nov 1, 2022
The Journal of Pathology, Mar 21, 2013
Epithelial tissues have sparse stroma, in contrast to their corresponding tumours. The effect of ... more Epithelial tissues have sparse stroma, in contrast to their corresponding tumours. The effect of cancer cells on stromal cells is well recognized. Increasingly, stromal components, such as endothelial and immune cells, are considered indispensable for cancer progression. The role of
Journal of Hepatology, 1994
of 61 consecutive patients undergoing laparoscopic cholecystectomy, 4 (6.25) developed abdominal ... more of 61 consecutive patients undergoing laparoscopic cholecystectomy, 4 (6.25) developed abdominal wall haematomas. This complication of laparoscopic cholecystectomy may occur more commonly than existing literature suggests, and manifests in the post-operative period (days 2 to 6) by visible bruising, excessive pain or an asymptomatic drop in haematocrit. It is readily confirmed by ultrasonography. While no specific treatment is necessary apart from replacement of significant blood loss, the patient requires reassurance that this apparently alarming complication will rapidly resolve.
International Journal of Surgery, 2010
Annals of Surgery, May 1, 2016
Trends in Urology & Men's Health
Pancreatic cancer carries a very poor prognosis, with five‐year survival currently approaching 10... more Pancreatic cancer carries a very poor prognosis, with five‐year survival currently approaching 10%. Late presentation, lack of effective treatment options and a tumour microenvironment that subverts immune mechanisms are some of the reasons behind this. Here the authors discuss how advances in our understanding of tumour biology, identification and surveillance of high‐risk groups, improvements in surgical outcomes and the availability of new chemotherapeutic options give us grounds for optimism.
European Journal of Endocrinology, 2010
ContextPreoperative localisation of insulinoma improves cure rate and reduces complications, but ... more ContextPreoperative localisation of insulinoma improves cure rate and reduces complications, but may be challenging.ObjectiveTo review diagnostic features and localisation accuracy for insulinomas.DesignCross-sectional, retrospective analysis.SettingA single tertiary referral centre.PatientsPatients with insulinoma in the years 1990–2009, including sporadic tumours and those in patients with multiple endocrine neoplasia syndromes.InterventionsPatients were identified from a database, and case notes and investigation results were reviewed. Tumour localisation by computed tomography (CT), magnetic resonance imaging (MRI), octreotide scanning, endoscopic ultrasound (EUS) and calcium stimulation was evaluated.Main outcome measure(s)Insulinoma localisation was compared to histologically confirmed location following surgical excision.ResultsThirty-seven instances of biochemically and/or histologically proven insulinoma were identified in 36 patients, of which seven were managed medically....
The Journal of Clinical Endocrinology & Metabolism, 2006
Background: Insulinomas are rare but are the most common cause of hyperinsulinemic hypoglycemia i... more Background: Insulinomas are rare but are the most common cause of hyperinsulinemic hypoglycemia in the adult population. Diagnosis of this pathology relies on clinical features along with laboratory tests and imaging investigations to aid in localization. One of the most robust standard tests used for establishing a biochemical diagnosis is the prolonged (72 h) fast. Currently, it is recommended that a prolonged supervised fast be performed, at least for 48 h if not for 72 h, and many would take the absence of hypoglycemia after a 72-h fast as evidence excluding the diagnosis. Methods: We employed prolonged fasts and standard glucose tolerance tests, plus imaging studies and surgical pathology, in two patients with suspected insulinomas. Results: The prolonged 72-h fast was normal in both the patients, whereas in both cases a prolonged oral glucose tolerance test clearly demonstrated the induction of severe hyperinsulinemia followed by significant hypoglycemia. Surgical removal conf...
Surgical Case Reports, 2021
Background: Major bile duct injuries (BDIs) are hazardous complications after laparoscopic cholec... more Background: Major bile duct injuries (BDIs) are hazardous complications after laparoscopic cholecystectomy (0.4%-0.6% of all laparoscopic cholecystectomies) [1, 2-4]. Major BDIs usually require surgery, ideally either within one week or after 3 three months after index surgery [1]. We describe the case of iatrogenic transection of the common bile duct (CBD) complicated by a complex full midline abdominal evisceration presented on day 12 after emergency laparotomy for biliary peritonitis. Case Presentation: A 65-year-old male underwent laparoscopic cholecystectomy in a district general hospital and was discharged on the same day, following apparently uneventful surgery. He, however, re-presented two days later with biliary peritonitis when emergency ERCP showed full CBD transection. The local surgical team performed midline exploratory laparotomy, washout, and external drainage aside the leaking CBD and referred the case to our tertiary HPB service. While awaiting transfer (due to be...
HPB, 2018
analysis, we compared the patients surviving more than 36 months after the operation, to the ones... more analysis, we compared the patients surviving more than 36 months after the operation, to the ones who did not reach this period. Biodemographic, clinical, histopathological and morbimortality data were compared between cases and controls using logistic regression. Results: Seventy patients were analyzed; mean age of 62, AE 11 years; 40 (57%) women. Mean and overall survival was 34 months and 22% at five years for the entire series. Mean resected lymph nodes was 18 AE 9. Twenty-one cases (30%) reached a survival greater than 36 months. At univariate analysis, R0 resection, the absence of positive lymph nodes, the absence of perineural infiltration and early stages (IA, IB and IIA) were associated with survival greater than 36 months (p < 0,05). After multivariable analysis, the absence of diabetes mellitus at the time of diagnosis (OR:12, 95% CI 1.7e84.3); the absence of perineural infiltration (OR: 7, 95% CI 1.3e36.3) and early stages (OR: 10, 05% CI 2.1e49.1) were demonstrated to be independent factors associated with survival greater than three years. Conclusion: Early stages of the disease, the absence of diabetes mellitus and no perineural infiltration at specimen were associated with survival greater than three years.
BMJ Open, 2016
Introduction: Remote video consultations between clinician and patient are technically possible a... more Introduction: Remote video consultations between clinician and patient are technically possible and increasingly acceptable. They are being introduced in some settings alongside (and occasionally replacing) face-to-face or telephone consultations. Methods: To explore the advantages and limitations of video consultations, we will conduct in-depth qualitative studies of real consultations (microlevel) embedded in an organisational case study (mesolevel), taking account of national context (macrolevel). The study is based in 2 contrasting clinical settings (diabetes and cancer) in a National Health Service (NHS) acute trust in London, UK. Main data sources are: microlevel-audio, video and screen capture to produce rich multimodal data on 45 remote consultations; mesolevel-interviews, ethnographic observations and analysis of documents within the trust; macrolevel-key informant interviews of national-level stakeholders and document analysis. Data will be analysed and synthesised using a sociotechnical framework developed from structuration theory.
European Journal of Surgical Oncology, 2018
, support, help and guidance during my internship and the last year of my PhD. I am thankful for ... more , support, help and guidance during my internship and the last year of my PhD. I am thankful for his guidance in our many discussions, as well as his genuine patience and positivity and his tireless effort in helping me move my career forward. I am forever grateful to have met him and worked with him. Finally, I would like to thank my family and friends whom I have probably not dedicated the amount of time they deserve, for their motivation and encouragement both in and out of the laboratory. To my parents, who supported me throughout my entire collegiate career; to my siblings who are and will always be my rock in daunting times; and to "My Person" Annie for being my daily sunshine and to the love of my life Karyll Hyacinthe, who motivated me to be the best engineer I can be. I thank you all.