Kiprofen (ketoprofen) dosing, indications, interactions, adverse effects, and more (original) (raw)

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Contraindicated (0)

Serious (21)

• aminolevulinic acid oral
  aminolevulinic acid oral, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.
• aminolevulinic acid topical
  ketoprofen, aminolevulinic acid topical. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.
• apixaban
  ketoprofen and apixaban both increase anticoagulation. Avoid or Use Alternate Drug.
• benazepril
  ketoprofen, benazepril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
• captopril
  ketoprofen, captopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
• enalapril
  ketoprofen, enalapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
• fosinopril
  ketoprofen, fosinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
• ketorolac
  ketoprofen, ketorolac. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.
• ketorolac intranasal
  ketoprofen, ketorolac intranasal. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.
• lisinopril
  ketoprofen, lisinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
• methotrexate
  ketoprofen increases levels of methotrexate by decreasing renal clearance. Avoid or Use Alternate Drug. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. NSAIDs may reduce tubular secretion of methotrexate and enhance toxicity. .
• methyl aminolevulinate
  ketoprofen, methyl aminolevulinate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.
• moexipril
  ketoprofen, moexipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
• pemetrexed
  ketoprofen increases levels of pemetrexed by unspecified interaction mechanism. Avoid or Use Alternate Drug. Interrupt dosing in all patients taking NSAIDs with long elimination half-lives for at least 5d before, the day of, and 2d following pemetrexed administration. If coadministration of an NSAID is necessary, closely monitor patients for toxicity, especially myelosuppression, renal toxicity, and GI toxicity.
• perindopril
  ketoprofen, perindopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
• quinapril
  ketoprofen, quinapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
• ramipril
  ketoprofen, ramipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.
• seladelpar
  ketoprofen will increase the level or effect of seladelpar by decreasing metabolism. Avoid or Use Alternate Drug. OAT3 inhibitors may increase seladelpar systemic exposure.
• sulopenem etzadroxil/probenecid
  sulopenem etzadroxil/probenecid increases levels of ketoprofen by decreasing metabolism. Avoid or Use Alternate Drug. Probenecid is an OAT1/3 inhibitor and may increase plasma concentrations of drugs that are dependent on OAT1/3 for elimination.
• tacrolimus
  ketoprofen, tacrolimus. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Concomitant administration increases risk of nephrotoxicity.
• trandolapril
  ketoprofen, trandolapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

Monitor Closely (231)

• acebutolol
  acebutolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of acebutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• aceclofenac
  aceclofenac and ketoprofen both increase anticoagulation. Use Caution/Monitor.aceclofenac and ketoprofen both increase serum potassium. Use Caution/Monitor.
• acemetacin
  acemetacin and ketoprofen both increase anticoagulation. Use Caution/Monitor.acemetacin and ketoprofen both increase serum potassium. Use Caution/Monitor.
• agrimony
  ketoprofen and agrimony both increase anticoagulation. Use Caution/Monitor.
• albuterol
  ketoprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• alfalfa
  ketoprofen and alfalfa both increase anticoagulation. Use Caution/Monitor.
• alfuzosin
  ketoprofen decreases effects of alfuzosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• aliskiren
  ketoprofen will decrease the level or effect of aliskiren by Other (see comment). Use Caution/Monitor. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Monitor renal function periodically.
• alteplase
  ketoprofen and alteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.
• American ginseng
  ketoprofen and American ginseng both increase anticoagulation. Use Caution/Monitor.
• amiloride
  amiloride and ketoprofen both increase serum potassium. Modify Therapy/Monitor Closely.
• antithrombin alfa
  antithrombin alfa and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• antithrombin III
  antithrombin III and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• arformoterol
  ketoprofen increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• argatroban
  argatroban and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• asenapine
  ketoprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• aspirin
  aspirin and ketoprofen both increase anticoagulation. Use Caution/Monitor.aspirin and ketoprofen both increase serum potassium. Use Caution/Monitor.
• aspirin rectal
  aspirin rectal and ketoprofen both increase anticoagulation. Use Caution/Monitor.aspirin rectal and ketoprofen both increase serum potassium. Use Caution/Monitor.
• aspirin/citric acid/sodium bicarbonate
  aspirin/citric acid/sodium bicarbonate and ketoprofen both increase anticoagulation. Use Caution/Monitor.aspirin/citric acid/sodium bicarbonate and ketoprofen both increase serum potassium. Use Caution/Monitor.
• atenolol
  atenolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• azficel-T
  azficel-T, ketoprofen. Other (see comment). Use Caution/Monitor. Comment: Patients taking NSAIDS may experience increased bruising or bleeding at biopsy and/or injection sites. Concomitant use of NSAIDs is not recommended.
• azilsartan
  ketoprofen, azilsartan. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.ketoprofen decreases effects of azilsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
• bemiparin
  bemiparin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• benazepril
  benazepril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• bendroflumethiazide
  ketoprofen increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• betaxolol
  betaxolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of betaxolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• betrixaban
  ketoprofen, betrixaban. Either increases levels of the other by anticoagulation. Use Caution/Monitor.
• bimatoprost
  bimatoprost, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
• bisoprolol
  bisoprolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of bisoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• bivalirudin
  bivalirudin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• budesonide
  ketoprofen, budesonide. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
• bumetanide
  ketoprofen increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.ketoprofen decreases effects of bumetanide by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• candesartan
  candesartan and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.candesartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• captopril
  captopril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• carbenoxolone
  ketoprofen increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• carvedilol
  carvedilol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• celecoxib
  celecoxib and ketoprofen both increase anticoagulation. Use Caution/Monitor.celecoxib and ketoprofen both increase serum potassium. Use Caution/Monitor.
• celiprolol
  celiprolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of celiprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• chlorothiazide
  ketoprofen increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• chlorthalidone
  ketoprofen increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• choline magnesium trisalicylate
  ketoprofen and choline magnesium trisalicylate both increase anticoagulation. Use Caution/Monitor.ketoprofen and choline magnesium trisalicylate both increase serum potassium. Use Caution/Monitor.
• cinnamon
  ketoprofen and cinnamon both increase anticoagulation. Use Caution/Monitor.
• ciprofloxacin
  ketoprofen, ciprofloxacin. Other (see comment). Modify Therapy/Monitor Closely. Comment: Mechanism: unknown. Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.
• citalopram
  citalopram, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. If possible, avoid concurrent use.
• clomipramine
  clomipramine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. Clomipramine inhib. serotonin uptake by platelets.
• clopidogrel
  clopidogrel, ketoprofen. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Clopidogrel and NSAIDs both inhibit platelet aggregation.
• cordyceps
  ketoprofen and cordyceps both increase anticoagulation. Use Caution/Monitor.
• cortisone
  ketoprofen, cortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
• cyclopenthiazide
  ketoprofen increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• cyclosporine
  ketoprofen, cyclosporine. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.
• dabigatran
  dabigatran and ketoprofen both increase anticoagulation. Use Caution/Monitor. Caution is advised, both drugs have the potential to cause bleeding. Concomitant use may increase risk of bleeding.
• dalteparin
  dalteparin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• deferasirox
  deferasirox, ketoprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase GI bleeding, ulceration and irritation. Use with caution.
• defibrotide
  defibrotide increases effects of ketoprofen by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Defibrotide may enhance effects of platelet inhibitors.
• deflazacort
  ketoprofen, deflazacort. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
• dexamethasone
  ketoprofen, dexamethasone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
• diclofenac
  diclofenac and ketoprofen both increase anticoagulation. Use Caution/Monitor.diclofenac and ketoprofen both increase serum potassium. Use Caution/Monitor.
• diflunisal
  diflunisal and ketoprofen both increase anticoagulation. Use Caution/Monitor.diflunisal and ketoprofen both increase serum potassium. Use Caution/Monitor.
• digoxin
  ketoprofen and digoxin both increase serum potassium. Use Caution/Monitor.
• dobutamine
  ketoprofen increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• dong quai
  ketoprofen and dong quai both increase anticoagulation. Use Caution/Monitor.
• dopexamine
  ketoprofen increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• doxazosin
  ketoprofen decreases effects of doxazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• drospirenone
  drospirenone and ketoprofen both increase serum potassium. Modify Therapy/Monitor Closely.
• duloxetine
  duloxetine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
• edoxaban
  edoxaban, ketoprofen. Either increases toxicity of the other by anticoagulation. Modify Therapy/Monitor Closely. Both drugs have the potential to cause bleeding, monitor closely. Promptly evaluate any signs or symptoms of blood loss.
• eltrombopag
  eltrombopag increases levels of ketoprofen by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.
• elvitegravir/cobicistat/emtricitabine/tenofovir DF
  elvitegravir/cobicistat/emtricitabine/tenofovir DF, ketoprofen. Either increases toxicity of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine and tenofovir with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.
• emtricitabine
  emtricitabine, ketoprofen. Either increases levels of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.
• enalapril
  enalapril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• enoxaparin
  enoxaparin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• ephedrine
  ketoprofen increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• epinephrine
  ketoprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• epinephrine racemic
  ketoprofen increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• epoprostenol
  ketoprofen and epoprostenol both increase anticoagulation. Use Caution/Monitor.
• eprosartan
  eprosartan and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of eprosartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.eprosartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• escitalopram
  escitalopram, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
• esmolol
  esmolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of esmolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• ethacrynic acid
  ketoprofen increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• etodolac
  etodolac and ketoprofen both increase anticoagulation. Use Caution/Monitor.etodolac and ketoprofen both increase serum potassium. Use Caution/Monitor.
• fennel
  ketoprofen and fennel both increase anticoagulation. Use Caution/Monitor.
• fenoprofen
  fenoprofen and ketoprofen both increase anticoagulation. Use Caution/Monitor.fenoprofen and ketoprofen both increase serum potassium. Use Caution/Monitor.
• feverfew
  ketoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.
• fish oil triglycerides
  fish oil triglycerides will increase the level or effect of ketoprofen by anticoagulation. Use Caution/Monitor. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Periodically monitor bleeding time in patients receiving fish oil triglycerides and concomitant antiplatelet agents or anticoagulants.
• fludrocortisone
  ketoprofen, fludrocortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
• fluoxetine
  fluoxetine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
• flurbiprofen
  flurbiprofen and ketoprofen both increase anticoagulation. Use Caution/Monitor.flurbiprofen and ketoprofen both increase serum potassium. Use Caution/Monitor.
• fluvoxamine
  fluvoxamine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding SSRIs inhib. serotonin uptake by platelets.
• fondaparinux
  fondaparinux and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• formoterol
  ketoprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• forskolin
  ketoprofen and forskolin both increase anticoagulation. Use Caution/Monitor.
• fosinopril
  fosinopril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• furosemide
  ketoprofen increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• garlic
  ketoprofen and garlic both increase anticoagulation. Use Caution/Monitor.
• gemifloxacin
  gemifloxacin, ketoprofen. Other (see comment). Modify Therapy/Monitor Closely. Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.
• gentamicin
  ketoprofen increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• ginger
  ketoprofen and ginger both increase anticoagulation. Use Caution/Monitor.
• ginkgo biloba
  ketoprofen and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.
• glimepiride
  ketoprofen increases effects of glimepiride by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
• glipizide
  ketoprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
• glyburide
  ketoprofen increases effects of glyburide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.
• green tea
  green tea, ketoprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.
• heparin
  heparin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• horse chestnut seed
  ketoprofen and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.
• hydralazine
  ketoprofen decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• hydrochlorothiazide
  ketoprofen increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• hydrocortisone
  ketoprofen, hydrocortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
• ibrutinib
  ibrutinib will increase the level or effect of ketoprofen by anticoagulation. Use Caution/Monitor. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding.
• ibuprofen
  ibuprofen and ketoprofen both increase anticoagulation. Use Caution/Monitor.ibuprofen and ketoprofen both increase serum potassium. Use Caution/Monitor.
• ibuprofen IV
  ibuprofen IV will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.ibuprofen IV and ketoprofen both increase anticoagulation. Use Caution/Monitor.ibuprofen IV and ketoprofen both increase serum potassium. Use Caution/Monitor.
• icosapent
  icosapent, ketoprofen. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Icosapent may prolong bleeding time. Periodically monitor if coadministered with other drugs that affect bleeding.
• imatinib
  imatinib, ketoprofen. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Comment: Imatinib may cause thrombocytopenia; bleeding risk increased when imatinib is coadministered with anticoagulants, NSAIDs, platelet inhibitors, and thrombolytic agents.
• indapamide
  ketoprofen increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• indomethacin
  indomethacin and ketoprofen both increase anticoagulation. Use Caution/Monitor.indomethacin and ketoprofen both increase serum potassium. Use Caution/Monitor.
• irbesartan
  irbesartan and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of irbesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.irbesartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• isoproterenol
  ketoprofen increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• ketorolac
  ketoprofen and ketorolac both increase anticoagulation. Use Caution/Monitor.ketoprofen and ketorolac both increase serum potassium. Use Caution/Monitor.
• ketorolac intranasal
  ketoprofen and ketorolac intranasal both increase anticoagulation. Use Caution/Monitor.ketoprofen and ketorolac intranasal both increase serum potassium. Use Caution/Monitor.
• labetalol
  labetalol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of labetalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• latanoprost
  latanoprost, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
• latanoprostene bunod ophthalmic
  latanoprostene bunod ophthalmic, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
• levalbuterol
  ketoprofen increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• levofloxacin
  levofloxacin, ketoprofen. Other (see comment). Modify Therapy/Monitor Closely. Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.
• levomilnacipran
  levomilnacipran, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. SNRIs may further impair platelet activity in patients taking antiplatelet or anticoagulant drugs.
• lisinopril
  lisinopril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• lithium
  ketoprofen increases levels of lithium by decreasing renal clearance. Use Caution/Monitor.
• lornoxicam
  ketoprofen and lornoxicam both increase anticoagulation. Use Caution/Monitor.ketoprofen and lornoxicam both increase serum potassium. Use Caution/Monitor.
• losartan
  losartan and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of losartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.losartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• meclofenamate
  meclofenamate and ketoprofen both increase anticoagulation. Use Caution/Monitor.meclofenamate and ketoprofen both increase serum potassium. Use Caution/Monitor.
• mefenamic acid
  ketoprofen and mefenamic acid both increase anticoagulation. Use Caution/Monitor.ketoprofen and mefenamic acid both increase serum potassium. Use Caution/Monitor.
• melatonin
  melatonin increases effects of ketoprofen by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.
• meloxicam
  ketoprofen and meloxicam both increase anticoagulation. Use Caution/Monitor.ketoprofen and meloxicam both increase serum potassium. Use Caution/Monitor.
• mesalamine
  mesalamine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive nephrotoxicity.
• metaproterenol
  ketoprofen increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• methyclothiazide
  ketoprofen increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .
• methylprednisolone
  ketoprofen, methylprednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
• metolazone
  ketoprofen increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• metoprolol
  metoprolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• milnacipran
  milnacipran, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
• mipomersen
  mipomersen, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.
• mistletoe
  ketoprofen increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• moexipril
  moexipril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• moxifloxacin
  moxifloxacin, ketoprofen. Other (see comment). Modify Therapy/Monitor Closely. Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.
• moxisylyte
  ketoprofen decreases effects of moxisylyte by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• mycophenolate
  ketoprofen will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.
• nabumetone
  ketoprofen and nabumetone both increase anticoagulation. Use Caution/Monitor.ketoprofen and nabumetone both increase serum potassium. Use Caution/Monitor.
• nadolol
  nadolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of nadolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• naproxen
  ketoprofen and naproxen both increase anticoagulation. Use Caution/Monitor.ketoprofen and naproxen both increase serum potassium. Use Caution/Monitor.
• nebivolol
  nebivolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of nebivolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• nefazodone
  nefazodone, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
• nettle
  ketoprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• norepinephrine
  ketoprofen increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• olmesartan
  olmesartan and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of olmesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.olmesartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• oxaprozin
  ketoprofen and oxaprozin both increase anticoagulation. Use Caution/Monitor.ketoprofen and oxaprozin both increase serum potassium. Use Caution/Monitor.
• panax ginseng
  ketoprofen and panax ginseng both increase anticoagulation. Use Caution/Monitor.
• parecoxib
  ketoprofen and parecoxib both increase anticoagulation. Use Caution/Monitor.ketoprofen and parecoxib both increase serum potassium. Use Caution/Monitor.
• paroxetine
  paroxetine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
• pau d'arco
  ketoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.
• pegaspargase
  pegaspargase increases effects of ketoprofen by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Increased risk of bleeding events.
• penbutolol
  penbutolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• perindopril
  perindopril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• phenindione
  phenindione and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• phenoxybenzamine
  ketoprofen decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• phentolamine
  ketoprofen decreases effects of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• phytoestrogens
  ketoprofen and phytoestrogens both increase anticoagulation. Use Caution/Monitor.
• pindolol
  pindolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of pindolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• pirbuterol
  ketoprofen increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• piroxicam
  ketoprofen and piroxicam both increase anticoagulation. Use Caution/Monitor.ketoprofen and piroxicam both increase serum potassium. Use Caution/Monitor.
• potassium acid phosphate
  ketoprofen and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.
• potassium chloride
  ketoprofen and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.
• potassium citrate
  ketoprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.
• potassium iodide
  potassium iodide and ketoprofen both increase serum potassium. Use Caution/Monitor.
• pralatrexate
  ketoprofen increases levels of pralatrexate by decreasing renal clearance. Use Caution/Monitor. NSAIDs may delay pralatrexate clearance, increasing drug exposure. Adjust the pralatrexate dose as needed.
• prasugrel
  ketoprofen, prasugrel. Either increases effects of the other by anticoagulation. Use Caution/Monitor. Chronic use of NSAIDs with prasugrel may increase bleeding risk.
• prazosin
  ketoprofen decreases effects of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• prednisolone
  ketoprofen, prednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
• prednisone
  ketoprofen, prednisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.
• probenecid
  ketoprofen will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.
• propranolol
  propranolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• protamine
  protamine and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.
• quinapril
  quinapril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• ramipril
  ramipril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• reishi
  ketoprofen and reishi both increase anticoagulation. Use Caution/Monitor.
• reteplase
  ketoprofen and reteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.
• rivaroxaban
  rivaroxaban, ketoprofen. Other (see comment). Use Caution/Monitor. Comment: NSAIDs are known to increase bleeding. Bleeding risk may be increased when NSAIDs are used concomitantly with rivaroxaban. Monitor for signs/symptoms of blood loss.
• rivastigmine
  rivastigmine increases toxicity of ketoprofen by pharmacodynamic synergism. Use Caution/Monitor. Monitor patients for symptoms of active or occult gastrointestinal bleeding.
• sacubitril/valsartan
  sacubitril/valsartan and ketoprofen both increase serum potassium. Use Caution/Monitor.sacubitril/valsartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.ketoprofen decreases effects of sacubitril/valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
• salicylates (non-asa)
  ketoprofen and salicylates (non-asa) both increase anticoagulation. Use Caution/Monitor.ketoprofen and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor.
• salmeterol
  ketoprofen increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• salsalate
  ketoprofen and salsalate both increase anticoagulation. Use Caution/Monitor.ketoprofen and salsalate both increase serum potassium. Use Caution/Monitor.
• saw palmetto
  saw palmetto increases toxicity of ketoprofen by unspecified interaction mechanism. Use Caution/Monitor. May increase risk of bleeding.
• sertraline
  sertraline, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
• Siberian ginseng
  ketoprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.
• silodosin
  ketoprofen decreases effects of silodosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• sodium picosulfate/magnesium oxide/anhydrous citric acid
  ketoprofen, sodium picosulfate/magnesium oxide/anhydrous citric acid. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May be associated with fluid and electrolyte imbalances.
• sodium sulfate/?magnesium sulfate/potassium chloride
  sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of ketoprofen by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.
• sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  ketoprofen, sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol. Other (see comment). Use Caution/Monitor. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance.
• sodium sulfate/potassium sulfate/magnesium sulfate
  sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of ketoprofen by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.
• sotalol
  sotalol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• sparsentan
  ketoprofen and sparsentan both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Coadministration of NSAIDS, including selective COX-2 inhibitors, may result in deterioration of kidney function (eg, possible kidney failure). Monitor for signs of worsening renal function with concomitant use with NSAIDs.
• spironolactone
  spironolactone and ketoprofen both increase serum potassium. Modify Therapy/Monitor Closely.
• succinylcholine
  ketoprofen and succinylcholine both increase serum potassium. Use Caution/Monitor.
• sulfasalazine
  ketoprofen and sulfasalazine both increase anticoagulation. Use Caution/Monitor.ketoprofen and sulfasalazine both increase serum potassium. Use Caution/Monitor.
• sulindac
  ketoprofen and sulindac both increase anticoagulation. Use Caution/Monitor.ketoprofen and sulindac both increase serum potassium. Use Caution/Monitor.
• tafluprost
  tafluprost, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
• telmisartan
  telmisartan and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of telmisartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.telmisartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• temocillin
  temocillin, ketoprofen. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.temocillin, ketoprofen. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.
• tenecteplase
  ketoprofen and tenecteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.
• tenofovir DF
  tenofovir DF, ketoprofen. Either increases levels of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of tenofovir DF with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.
• terazosin
  ketoprofen decreases effects of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
• terbutaline
  ketoprofen increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• ticagrelor
  ticagrelor, ketoprofen. Either increases effects of the other by anticoagulation. Use Caution/Monitor. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. .
• timolol
  timolol and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of timolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
• tolfenamic acid
  ketoprofen and tolfenamic acid both increase anticoagulation. Use Caution/Monitor.ketoprofen and tolfenamic acid both increase serum potassium. Use Caution/Monitor.
• tolmetin
  ketoprofen and tolmetin both increase anticoagulation. Use Caution/Monitor.ketoprofen and tolmetin both increase serum potassium. Use Caution/Monitor.
• tolvaptan
  ketoprofen and tolvaptan both increase serum potassium. Use Caution/Monitor.
• torsemide
  ketoprofen increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• trandolapril
  trandolapril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• travoprost ophthalmic
  travoprost ophthalmic, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).
• trazodone
  trazodone, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
• triamcinolone acetonide injectable suspension
  ketoprofen, triamcinolone acetonide injectable suspension. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Concomitant use of NSAIDS and corticosteroids increases the risk of gastrointestinal side effects. .
• triamterene
  triamterene and ketoprofen both increase serum potassium. Modify Therapy/Monitor Closely.
• valsartan
  valsartan and ketoprofen both increase serum potassium. Use Caution/Monitor.ketoprofen decreases effects of valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.valsartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
• venlafaxine
  venlafaxine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.
• vitamin K1 (phytonadione)
  ketoprofen increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.
• voclosporin
  voclosporin, ketoprofen. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.
• vorapaxar
  ketoprofen, vorapaxar. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive antiplatelet effect may occur.
• vortioxetine
  ketoprofen, vortioxetine. Either increases effects of the other by anticoagulation. Use Caution/Monitor.
• warfarin
  ketoprofen, warfarin. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Drugs with antiplatelet properties may increase anticoagulation effect of warfarin.
• zanubrutinib
  ketoprofen, zanubrutinib. Either increases effects of the other by anticoagulation. Modify Therapy/Monitor Closely. Zanubrutinib-induced cytopenias increases risk of hemorrhage. Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk.
• zotepine
  ketoprofen decreases effects of zotepine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

Minor (72)

• aceclofenac
  aceclofenac will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• acemetacin
  acemetacin will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• acyclovir
  ketoprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• alendronate
  ketoprofen, alendronate. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of GI ulceration.

• amikacin
  ketoprofen increases levels of amikacin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• aminohippurate sodium
  ketoprofen will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• anamu
  ketoprofen and anamu both increase anticoagulation. Minor/Significance Unknown.

• aspirin
  aspirin will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• aspirin rectal
  aspirin rectal will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• aspirin/citric acid/sodium bicarbonate
  aspirin/citric acid/sodium bicarbonate will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• balsalazide
  ketoprofen will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• bendroflumethiazide
  bendroflumethiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• cefadroxil
  cefadroxil will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• cefamandole
  cefamandole will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• cefpirome
  cefpirome will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• ceftibuten
  ceftibuten will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• celecoxib
  celecoxib will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• cephalexin
  cephalexin will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• chlorothiazide
  chlorothiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• chlorthalidone
  chlorthalidone will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• choline magnesium trisalicylate
  ketoprofen will increase the level or effect of choline magnesium trisalicylate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• creatine
  creatine, ketoprofen. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction) Combination may have additive nephrotoxic effects.

• cyclopenthiazide
  cyclopenthiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• danshen
  ketoprofen and danshen both increase anticoagulation. Minor/Significance Unknown.

• devil's claw
  ketoprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

• diclofenac
  diclofenac will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• diclofenac topical
  diclofenac topical, ketoprofen. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Although low, there is systemic exposure to diclofenac topical; theoretically, concomitant administration with systemic NSAIDS or aspirin may result in increased NSAID adverse effects.

• diflunisal
  diflunisal will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• eplerenone
  ketoprofen decreases effects of eplerenone by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

• etodolac
  etodolac will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• fenoprofen
  fenoprofen will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• feverfew
  ketoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

• flurbiprofen
  flurbiprofen will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• furosemide
  ketoprofen decreases effects of furosemide by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

• ganciclovir
  ketoprofen will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• gentamicin
  ketoprofen increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• hydrochlorothiazide
  hydrochlorothiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• ibuprofen
  ibuprofen will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• imidapril
  ketoprofen decreases effects of imidapril by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

• indapamide
  indapamide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• indomethacin
  indomethacin will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• ketorolac
  ketoprofen will increase the level or effect of ketorolac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• ketorolac intranasal
  ketoprofen will increase the level or effect of ketorolac intranasal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• lornoxicam
  ketoprofen will increase the level or effect of lornoxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• meclofenamate
  meclofenamate will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• mefenamic acid
  ketoprofen will increase the level or effect of mefenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• meloxicam
  ketoprofen will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• mesalamine
  ketoprofen will increase the level or effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• methyclothiazide
  methyclothiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• metolazone
  metolazone will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• nabumetone
  ketoprofen will increase the level or effect of nabumetone by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• naproxen
  ketoprofen will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• neomycin PO
  ketoprofen increases levels of neomycin PO by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• noni juice
  ketoprofen and noni juice both increase serum potassium. Minor/Significance Unknown.

• ofloxacin
  ofloxacin, ketoprofen. Other (see comment). Minor/Significance Unknown. Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.

• oxaprozin
  ketoprofen will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• parecoxib
  ketoprofen will increase the level or effect of parecoxib by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• paromomycin
  ketoprofen increases levels of paromomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• piroxicam
  ketoprofen will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• rose hips
  rose hips will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• salicylates (non-asa)
  ketoprofen will increase the level or effect of salicylates (non-asa) by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• salsalate
  ketoprofen will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• streptomycin
  ketoprofen increases levels of streptomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• sulfasalazine
  ketoprofen will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• sulindac
  ketoprofen will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• tobramycin
  ketoprofen increases levels of tobramycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• tolfenamic acid
  ketoprofen will increase the level or effect of tolfenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• tolmetin
  ketoprofen will increase the level or effect of tolmetin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• triamterene
  triamterene, ketoprofen. Other (see comment). Minor/Significance Unknown. Comment: Risk of acute renal failure. Mechanism: NSAIDs decrease prostaglandin synthesis, which normally protect against nephrotoxicity.ketoprofen increases toxicity of triamterene by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis, increasing the risk of nephrotoxicity.

• valganciclovir
  ketoprofen will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• vancomycin
  ketoprofen increases levels of vancomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in neonates.

• willow bark
  ketoprofen will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• acebutolol
  Monitor Closely (2)ketoprofen decreases effects of acebutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  acebutolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• aceclofenac
  Monitor Closely (2)aceclofenac and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  aceclofenac and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)aceclofenac will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• acemetacin
  Monitor Closely (2)acemetacin and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  acemetacin and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)acemetacin will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• acyclovir
  Minor (1)ketoprofen will increase the level or effect of acyclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• agrimony
  Monitor Closely (1)ketoprofen and agrimony both increase anticoagulation. Use Caution/Monitor.

• albuterol
  Monitor Closely (1)ketoprofen increases and albuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• alendronate
  Minor (1)ketoprofen, alendronate. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. Increased risk of GI ulceration.

• alfalfa
  Monitor Closely (1)ketoprofen and alfalfa both increase anticoagulation. Use Caution/Monitor.

• alfuzosin
  Monitor Closely (1)ketoprofen decreases effects of alfuzosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• aliskiren
  Monitor Closely (1)ketoprofen will decrease the level or effect of aliskiren by Other (see comment). Use Caution/Monitor. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Monitor renal function periodically.

• alteplase
  Monitor Closely (1)ketoprofen and alteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.

• American ginseng
  Monitor Closely (1)ketoprofen and American ginseng both increase anticoagulation. Use Caution/Monitor.

• amikacin
  Minor (1)ketoprofen increases levels of amikacin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• amiloride
  Monitor Closely (1)amiloride and ketoprofen both increase serum potassium. Modify Therapy/Monitor Closely.

• aminohippurate sodium
  Minor (1)ketoprofen will increase the level or effect of aminohippurate sodium by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• aminolevulinic acid oral
  Serious - Use Alternative (1)aminolevulinic acid oral, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period.

• aminolevulinic acid topical
  Serious - Use Alternative (1)ketoprofen, aminolevulinic acid topical. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.

• anamu
  Minor (1)ketoprofen and anamu both increase anticoagulation. Minor/Significance Unknown.

• antithrombin alfa
  Monitor Closely (1)antithrombin alfa and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• antithrombin III
  Monitor Closely (1)antithrombin III and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• apixaban
  Serious - Use Alternative (1)ketoprofen and apixaban both increase anticoagulation. Avoid or Use Alternate Drug.

• arformoterol
  Monitor Closely (1)ketoprofen increases and arformoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• argatroban
  Monitor Closely (1)argatroban and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• asenapine
  Monitor Closely (1)ketoprofen decreases effects of asenapine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• aspirin
  Monitor Closely (2)aspirin and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  aspirin and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)aspirin will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• aspirin rectal
  Monitor Closely (2)aspirin rectal and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  aspirin rectal and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)aspirin rectal will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• aspirin/citric acid/sodium bicarbonate
  Monitor Closely (2)aspirin/citric acid/sodium bicarbonate and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  aspirin/citric acid/sodium bicarbonate and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)aspirin/citric acid/sodium bicarbonate will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• atenolol
  Monitor Closely (2)ketoprofen decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  atenolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• azficel-T
  Monitor Closely (1)azficel-T, ketoprofen. Other (see comment). Use Caution/Monitor. Comment: Patients taking NSAIDS may experience increased bruising or bleeding at biopsy and/or injection sites. Concomitant use of NSAIDs is not recommended.

• azilsartan
  Monitor Closely (2)ketoprofen, azilsartan. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
  ketoprofen decreases effects of azilsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.

• balsalazide
  Minor (1)ketoprofen will increase the level or effect of balsalazide by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• bemiparin
  Monitor Closely (1)bemiparin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• benazepril
  Monitor Closely (1)benazepril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, benazepril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• bendroflumethiazide
  Monitor Closely (1)ketoprofen increases and bendroflumethiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)bendroflumethiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• betaxolol
  Monitor Closely (2)ketoprofen decreases effects of betaxolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  betaxolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• betrixaban
  Monitor Closely (1)ketoprofen, betrixaban. Either increases levels of the other by anticoagulation. Use Caution/Monitor.

• bimatoprost
  Monitor Closely (1)bimatoprost, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

• bisoprolol
  Monitor Closely (2)ketoprofen decreases effects of bisoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  bisoprolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• bivalirudin
  Monitor Closely (1)bivalirudin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• budesonide
  Monitor Closely (1)ketoprofen, budesonide. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

• bumetanide
  Monitor Closely (2)ketoprofen decreases effects of bumetanide by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.
  ketoprofen increases and bumetanide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• candesartan
  Monitor Closely (3)candesartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
  ketoprofen decreases effects of candesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
  candesartan and ketoprofen both increase serum potassium. Use Caution/Monitor.

• captopril
  Monitor Closely (1)captopril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, captopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• carbenoxolone
  Monitor Closely (1)ketoprofen increases and carbenoxolone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• carvedilol
  Monitor Closely (2)ketoprofen decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  carvedilol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• cefadroxil
  Minor (1)cefadroxil will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• cefamandole
  Minor (1)cefamandole will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• cefpirome
  Minor (1)cefpirome will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• ceftibuten
  Minor (1)ceftibuten will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• celecoxib
  Monitor Closely (2)celecoxib and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  celecoxib and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)celecoxib will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• celiprolol
  Monitor Closely (2)ketoprofen decreases effects of celiprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  celiprolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• cephalexin
  Minor (1)cephalexin will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• chlorothiazide
  Monitor Closely (1)ketoprofen increases and chlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)chlorothiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• chlorthalidone
  Monitor Closely (1)ketoprofen increases and chlorthalidone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)chlorthalidone will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• choline magnesium trisalicylate
  Monitor Closely (2)ketoprofen and choline magnesium trisalicylate both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and choline magnesium trisalicylate both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of choline magnesium trisalicylate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• cinnamon
  Monitor Closely (1)ketoprofen and cinnamon both increase anticoagulation. Use Caution/Monitor.

• ciprofloxacin
  Monitor Closely (1)ketoprofen, ciprofloxacin. Other (see comment). Modify Therapy/Monitor Closely. Comment: Mechanism: unknown. Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.

• citalopram
  Monitor Closely (1)citalopram, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. If possible, avoid concurrent use.

• clomipramine
  Monitor Closely (1)clomipramine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. Clomipramine inhib. serotonin uptake by platelets.

• clopidogrel
  Monitor Closely (1)clopidogrel, ketoprofen. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Clopidogrel and NSAIDs both inhibit platelet aggregation.

• cordyceps
  Monitor Closely (1)ketoprofen and cordyceps both increase anticoagulation. Use Caution/Monitor.

• cortisone
  Monitor Closely (1)ketoprofen, cortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

• creatine
  Minor (1)creatine, ketoprofen. Mechanism: pharmacodynamic synergism. Minor/Significance Unknown. (Theoretical interaction) Combination may have additive nephrotoxic effects.

• cyclopenthiazide
  Monitor Closely (1)ketoprofen increases and cyclopenthiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)cyclopenthiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• cyclosporine
  Monitor Closely (1)ketoprofen, cyclosporine. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely.

• dabigatran
  Monitor Closely (1)dabigatran and ketoprofen both increase anticoagulation. Use Caution/Monitor. Caution is advised, both drugs have the potential to cause bleeding. Concomitant use may increase risk of bleeding.

• dalteparin
  Monitor Closely (1)dalteparin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• danshen
  Minor (1)ketoprofen and danshen both increase anticoagulation. Minor/Significance Unknown.

• deferasirox
  Monitor Closely (1)deferasirox, ketoprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase GI bleeding, ulceration and irritation. Use with caution.

• defibrotide
  Monitor Closely (1)defibrotide increases effects of ketoprofen by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Defibrotide may enhance effects of platelet inhibitors.

• deflazacort
  Monitor Closely (1)ketoprofen, deflazacort. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

• devil's claw
  Minor (1)ketoprofen and devil's claw both increase anticoagulation. Minor/Significance Unknown.

• dexamethasone
  Monitor Closely (1)ketoprofen, dexamethasone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

• diclofenac
  Monitor Closely (2)diclofenac and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  diclofenac and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)diclofenac will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• diclofenac topical
  Minor (1)diclofenac topical, ketoprofen. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Although low, there is systemic exposure to diclofenac topical; theoretically, concomitant administration with systemic NSAIDS or aspirin may result in increased NSAID adverse effects.

• diflunisal
  Monitor Closely (2)diflunisal and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  diflunisal and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)diflunisal will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• digoxin
  Monitor Closely (1)ketoprofen and digoxin both increase serum potassium. Use Caution/Monitor.

• dobutamine
  Monitor Closely (1)ketoprofen increases and dobutamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• dong quai
  Monitor Closely (1)ketoprofen and dong quai both increase anticoagulation. Use Caution/Monitor.

• dopexamine
  Monitor Closely (1)ketoprofen increases and dopexamine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• doxazosin
  Monitor Closely (1)ketoprofen decreases effects of doxazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• drospirenone
  Monitor Closely (1)drospirenone and ketoprofen both increase serum potassium. Modify Therapy/Monitor Closely.

• duloxetine
  Monitor Closely (1)duloxetine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

• edoxaban
  Monitor Closely (1)edoxaban, ketoprofen. Either increases toxicity of the other by anticoagulation. Modify Therapy/Monitor Closely. Both drugs have the potential to cause bleeding, monitor closely. Promptly evaluate any signs or symptoms of blood loss.

• eltrombopag
  Monitor Closely (1)eltrombopag increases levels of ketoprofen by decreasing metabolism. Use Caution/Monitor. UGT inhibition; significance of interaction unclear.

• elvitegravir/cobicistat/emtricitabine/tenofovir DF
  Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF, ketoprofen. Either increases toxicity of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine and tenofovir with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

• emtricitabine
  Monitor Closely (1)emtricitabine, ketoprofen. Either increases levels of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of emtricitabine with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

• enalapril
  Monitor Closely (1)enalapril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, enalapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• enoxaparin
  Monitor Closely (1)enoxaparin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• ephedrine
  Monitor Closely (1)ketoprofen increases and ephedrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• epinephrine
  Monitor Closely (1)ketoprofen increases and epinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• epinephrine racemic
  Monitor Closely (1)ketoprofen increases and epinephrine racemic decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• eplerenone
  Minor (1)ketoprofen decreases effects of eplerenone by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

• epoprostenol
  Monitor Closely (1)ketoprofen and epoprostenol both increase anticoagulation. Use Caution/Monitor.

• eprosartan
  Monitor Closely (3)ketoprofen decreases effects of eprosartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
  eprosartan and ketoprofen both increase serum potassium. Use Caution/Monitor.
  eprosartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.

• escitalopram
  Monitor Closely (1)escitalopram, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

• esmolol
  Monitor Closely (2)ketoprofen decreases effects of esmolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  esmolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• ethacrynic acid
  Monitor Closely (1)ketoprofen increases and ethacrynic acid decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• etodolac
  Monitor Closely (2)etodolac and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  etodolac and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)etodolac will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• fennel
  Monitor Closely (1)ketoprofen and fennel both increase anticoagulation. Use Caution/Monitor.

• fenoprofen
  Monitor Closely (2)fenoprofen and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  fenoprofen and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)fenoprofen will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• feverfew
  Monitor Closely (1)ketoprofen and feverfew both increase anticoagulation. Use Caution/Monitor.Minor (1)ketoprofen decreases effects of feverfew by pharmacodynamic antagonism. Minor/Significance Unknown.

• fish oil triglycerides
  Monitor Closely (1)fish oil triglycerides will increase the level or effect of ketoprofen by anticoagulation. Use Caution/Monitor. Prolonged bleeding reported in patients taking antiplatelet agents or anticoagulants and oral omega-3 fatty acids. Periodically monitor bleeding time in patients receiving fish oil triglycerides and concomitant antiplatelet agents or anticoagulants.

• fludrocortisone
  Monitor Closely (1)ketoprofen, fludrocortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

• fluoxetine
  Monitor Closely (1)fluoxetine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

• flurbiprofen
  Monitor Closely (2)flurbiprofen and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  flurbiprofen and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)flurbiprofen will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• fluvoxamine
  Monitor Closely (1)fluvoxamine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding SSRIs inhib. serotonin uptake by platelets.

• fondaparinux
  Monitor Closely (1)fondaparinux and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• formoterol
  Monitor Closely (1)ketoprofen increases and formoterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• forskolin
  Monitor Closely (1)ketoprofen and forskolin both increase anticoagulation. Use Caution/Monitor.

• fosinopril
  Monitor Closely (1)fosinopril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, fosinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• furosemide
  Monitor Closely (1)ketoprofen increases and furosemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)ketoprofen decreases effects of furosemide by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

• ganciclovir
  Minor (1)ketoprofen will increase the level or effect of ganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• garlic
  Monitor Closely (1)ketoprofen and garlic both increase anticoagulation. Use Caution/Monitor.

• gemifloxacin
  Monitor Closely (1)gemifloxacin, ketoprofen. Other (see comment). Modify Therapy/Monitor Closely. Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.

• gentamicin
  Monitor Closely (1)ketoprofen increases and gentamicin decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)ketoprofen increases levels of gentamicin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• ginger
  Monitor Closely (1)ketoprofen and ginger both increase anticoagulation. Use Caution/Monitor.

• ginkgo biloba
  Monitor Closely (1)ketoprofen and ginkgo biloba both increase anticoagulation. Use Caution/Monitor.

• glimepiride
  Monitor Closely (1)ketoprofen increases effects of glimepiride by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

• glipizide
  Monitor Closely (1)ketoprofen increases effects of glipizide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

• glyburide
  Monitor Closely (1)ketoprofen increases effects of glyburide by unknown mechanism. Use Caution/Monitor. Risk of hypoglycemia.

• green tea
  Monitor Closely (1)green tea, ketoprofen. Other (see comment). Use Caution/Monitor. Comment: Combination may increase risk of bleeding.

• heparin
  Monitor Closely (1)heparin and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• horse chestnut seed
  Monitor Closely (1)ketoprofen and horse chestnut seed both increase anticoagulation. Use Caution/Monitor.

• hydralazine
  Monitor Closely (1)ketoprofen decreases effects of hydralazine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• hydrochlorothiazide
  Monitor Closely (1)ketoprofen increases and hydrochlorothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)hydrochlorothiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• hydrocortisone
  Monitor Closely (1)ketoprofen, hydrocortisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

• ibrutinib
  Monitor Closely (1)ibrutinib will increase the level or effect of ketoprofen by anticoagulation. Use Caution/Monitor. Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding.

• ibuprofen
  Monitor Closely (2)ibuprofen and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  ibuprofen and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)ibuprofen will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• ibuprofen IV
  Monitor Closely (3)ibuprofen IV will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.
  ibuprofen IV and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  ibuprofen IV and ketoprofen both increase serum potassium. Use Caution/Monitor.

• icosapent
  Monitor Closely (1)icosapent, ketoprofen. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Icosapent may prolong bleeding time. Periodically monitor if coadministered with other drugs that affect bleeding.

• imatinib
  Monitor Closely (1)imatinib, ketoprofen. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Comment: Imatinib may cause thrombocytopenia; bleeding risk increased when imatinib is coadministered with anticoagulants, NSAIDs, platelet inhibitors, and thrombolytic agents.

• imidapril
  Minor (1)ketoprofen decreases effects of imidapril by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis.

• indapamide
  Monitor Closely (1)ketoprofen increases and indapamide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)indapamide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• indomethacin
  Monitor Closely (2)indomethacin and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  indomethacin and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)indomethacin will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• irbesartan
  Monitor Closely (3)irbesartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
  ketoprofen decreases effects of irbesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
  irbesartan and ketoprofen both increase serum potassium. Use Caution/Monitor.

• isoproterenol
  Monitor Closely (1)ketoprofen increases and isoproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ketorolac
  Monitor Closely (2)ketoprofen and ketorolac both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and ketorolac both increase serum potassium. Use Caution/Monitor.Serious - Use Alternative (1)ketoprofen, ketorolac. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.Minor (1)ketoprofen will increase the level or effect of ketorolac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• ketorolac intranasal
  Monitor Closely (2)ketoprofen and ketorolac intranasal both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and ketorolac intranasal both increase serum potassium. Use Caution/Monitor.Serious - Use Alternative (1)ketoprofen, ketorolac intranasal. Either increases toxicity of the other by pharmacodynamic synergism. Contraindicated.Minor (1)ketoprofen will increase the level or effect of ketorolac intranasal by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• labetalol
  Monitor Closely (2)ketoprofen decreases effects of labetalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  labetalol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• latanoprost
  Monitor Closely (1)latanoprost, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

• latanoprostene bunod ophthalmic
  Monitor Closely (1)latanoprostene bunod ophthalmic, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

• levalbuterol
  Monitor Closely (1)ketoprofen increases and levalbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• levofloxacin
  Monitor Closely (1)levofloxacin, ketoprofen. Other (see comment). Modify Therapy/Monitor Closely. Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.

• levomilnacipran
  Monitor Closely (1)levomilnacipran, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. SNRIs may further impair platelet activity in patients taking antiplatelet or anticoagulant drugs.

• lisinopril
  Monitor Closely (1)lisinopril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, lisinopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• lithium
  Monitor Closely (1)ketoprofen increases levels of lithium by decreasing renal clearance. Use Caution/Monitor.

• lornoxicam
  Monitor Closely (2)ketoprofen and lornoxicam both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and lornoxicam both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of lornoxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• losartan
  Monitor Closely (3)losartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
  ketoprofen decreases effects of losartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
  losartan and ketoprofen both increase serum potassium. Use Caution/Monitor.

• meclofenamate
  Monitor Closely (2)meclofenamate and ketoprofen both increase anticoagulation. Use Caution/Monitor.
  meclofenamate and ketoprofen both increase serum potassium. Use Caution/Monitor.Minor (1)meclofenamate will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• mefenamic acid
  Monitor Closely (2)ketoprofen and mefenamic acid both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and mefenamic acid both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of mefenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• melatonin
  Monitor Closely (1)melatonin increases effects of ketoprofen by anticoagulation. Use Caution/Monitor. Melatonin may decrease prothrombin time.

• meloxicam
  Monitor Closely (2)ketoprofen and meloxicam both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and meloxicam both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of meloxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• mesalamine
  Monitor Closely (1)mesalamine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive nephrotoxicity.Minor (1)ketoprofen will increase the level or effect of mesalamine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• metaproterenol
  Monitor Closely (1)ketoprofen increases and metaproterenol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• methotrexate
  Serious - Use Alternative (1)ketoprofen increases levels of methotrexate by decreasing renal clearance. Avoid or Use Alternate Drug. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. NSAIDs may reduce tubular secretion of methotrexate and enhance toxicity. .

• methyclothiazide
  Monitor Closely (1)ketoprofen increases and methyclothiazide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor. .Minor (1)methyclothiazide will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• methyl aminolevulinate
  Serious - Use Alternative (1)ketoprofen, methyl aminolevulinate. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Each drug may increase the photosensitizing effect of the other.

• methylprednisolone
  Monitor Closely (1)ketoprofen, methylprednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

• metolazone
  Monitor Closely (1)ketoprofen increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.Minor (1)metolazone will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• metoprolol
  Monitor Closely (2)ketoprofen decreases effects of metoprolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  metoprolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• milnacipran
  Monitor Closely (1)milnacipran, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

• mipomersen
  Monitor Closely (1)mipomersen, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: Both drugs have potential to increase hepatic enzymes; monitor LFTs.

• mistletoe
  Monitor Closely (1)ketoprofen increases and mistletoe decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• moexipril
  Monitor Closely (1)moexipril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, moexipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• moxifloxacin
  Monitor Closely (1)moxifloxacin, ketoprofen. Other (see comment). Modify Therapy/Monitor Closely. Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones.

• moxisylyte
  Monitor Closely (1)ketoprofen decreases effects of moxisylyte by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• mycophenolate
  Monitor Closely (1)ketoprofen will increase the level or effect of mycophenolate by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.

• nabumetone
  Monitor Closely (2)ketoprofen and nabumetone both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and nabumetone both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of nabumetone by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• nadolol
  Monitor Closely (2)ketoprofen decreases effects of nadolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  nadolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• naproxen
  Monitor Closely (2)ketoprofen and naproxen both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and naproxen both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of naproxen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• nebivolol
  Monitor Closely (2)ketoprofen decreases effects of nebivolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  nebivolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• nefazodone
  Monitor Closely (1)nefazodone, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

• neomycin PO
  Minor (1)ketoprofen increases levels of neomycin PO by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• nettle
  Monitor Closely (1)ketoprofen increases and nettle decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• noni juice
  Minor (1)ketoprofen and noni juice both increase serum potassium. Minor/Significance Unknown.

• norepinephrine
  Monitor Closely (1)ketoprofen increases and norepinephrine decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ofloxacin
  Minor (1)ofloxacin, ketoprofen. Other (see comment). Minor/Significance Unknown. Comment: Risk of CNS stimulation/seizure. Mechanism: Displacement of GABA from receptors in brain.

• olmesartan
  Monitor Closely (3)olmesartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
  ketoprofen decreases effects of olmesartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
  olmesartan and ketoprofen both increase serum potassium. Use Caution/Monitor.

• oxaprozin
  Monitor Closely (2)ketoprofen and oxaprozin both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and oxaprozin both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of oxaprozin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• panax ginseng
  Monitor Closely (1)ketoprofen and panax ginseng both increase anticoagulation. Use Caution/Monitor.

• parecoxib
  Monitor Closely (2)ketoprofen and parecoxib both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and parecoxib both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of parecoxib by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• paromomycin
  Minor (1)ketoprofen increases levels of paromomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• paroxetine
  Monitor Closely (1)paroxetine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

• pau d'arco
  Monitor Closely (1)ketoprofen and pau d'arco both increase anticoagulation. Use Caution/Monitor.

• pegaspargase
  Monitor Closely (1)pegaspargase increases effects of ketoprofen by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Increased risk of bleeding events.

• pemetrexed
  Serious - Use Alternative (1)ketoprofen increases levels of pemetrexed by unspecified interaction mechanism. Avoid or Use Alternate Drug. Interrupt dosing in all patients taking NSAIDs with long elimination half-lives for at least 5d before, the day of, and 2d following pemetrexed administration. If coadministration of an NSAID is necessary, closely monitor patients for toxicity, especially myelosuppression, renal toxicity, and GI toxicity.

• penbutolol
  Monitor Closely (2)ketoprofen decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  penbutolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• perindopril
  Monitor Closely (1)perindopril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, perindopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• phenindione
  Monitor Closely (1)phenindione and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• phenoxybenzamine
  Monitor Closely (1)ketoprofen decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• phentolamine
  Monitor Closely (1)ketoprofen decreases effects of phentolamine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• phytoestrogens
  Monitor Closely (1)ketoprofen and phytoestrogens both increase anticoagulation. Use Caution/Monitor.

• pindolol
  Monitor Closely (2)ketoprofen decreases effects of pindolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  pindolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• pirbuterol
  Monitor Closely (1)ketoprofen increases and pirbuterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• piroxicam
  Monitor Closely (2)ketoprofen and piroxicam both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and piroxicam both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of piroxicam by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• potassium acid phosphate
  Monitor Closely (1)ketoprofen and potassium acid phosphate both increase serum potassium. Modify Therapy/Monitor Closely.

• potassium chloride
  Monitor Closely (1)ketoprofen and potassium chloride both increase serum potassium. Modify Therapy/Monitor Closely.

• potassium citrate
  Monitor Closely (1)ketoprofen and potassium citrate both increase serum potassium. Modify Therapy/Monitor Closely.

• potassium iodide
  Monitor Closely (1)potassium iodide and ketoprofen both increase serum potassium. Use Caution/Monitor.

• pralatrexate
  Monitor Closely (1)ketoprofen increases levels of pralatrexate by decreasing renal clearance. Use Caution/Monitor. NSAIDs may delay pralatrexate clearance, increasing drug exposure. Adjust the pralatrexate dose as needed.

• prasugrel
  Monitor Closely (1)ketoprofen, prasugrel. Either increases effects of the other by anticoagulation. Use Caution/Monitor. Chronic use of NSAIDs with prasugrel may increase bleeding risk.

• prazosin
  Monitor Closely (1)ketoprofen decreases effects of prazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• prednisolone
  Monitor Closely (1)ketoprofen, prednisolone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

• prednisone
  Monitor Closely (1)ketoprofen, prednisone. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of GI ulceration.

• probenecid
  Monitor Closely (1)ketoprofen will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.

• propranolol
  Monitor Closely (2)ketoprofen decreases effects of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  propranolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• protamine
  Monitor Closely (1)protamine and ketoprofen both increase anticoagulation. Modify Therapy/Monitor Closely.

• quinapril
  Monitor Closely (1)quinapril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, quinapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• ramipril
  Monitor Closely (1)ramipril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, ramipril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• reishi
  Monitor Closely (1)ketoprofen and reishi both increase anticoagulation. Use Caution/Monitor.

• reteplase
  Monitor Closely (1)ketoprofen and reteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.

• rivaroxaban
  Monitor Closely (1)rivaroxaban, ketoprofen. Other (see comment). Use Caution/Monitor. Comment: NSAIDs are known to increase bleeding. Bleeding risk may be increased when NSAIDs are used concomitantly with rivaroxaban. Monitor for signs/symptoms of blood loss.

• rivastigmine
  Monitor Closely (1)rivastigmine increases toxicity of ketoprofen by pharmacodynamic synergism. Use Caution/Monitor. Monitor patients for symptoms of active or occult gastrointestinal bleeding.

• rose hips
  Minor (1)rose hips will increase the level or effect of ketoprofen by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• sacubitril/valsartan
  Monitor Closely (3)sacubitril/valsartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
  ketoprofen decreases effects of sacubitril/valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
  sacubitril/valsartan and ketoprofen both increase serum potassium. Use Caution/Monitor.

• salicylates (non-asa)
  Monitor Closely (2)ketoprofen and salicylates (non-asa) both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and salicylates (non-asa) both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of salicylates (non-asa) by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• salmeterol
  Monitor Closely (1)ketoprofen increases and salmeterol decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• salsalate
  Monitor Closely (2)ketoprofen and salsalate both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and salsalate both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of salsalate by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• saw palmetto
  Monitor Closely (1)saw palmetto increases toxicity of ketoprofen by unspecified interaction mechanism. Use Caution/Monitor. May increase risk of bleeding.

• seladelpar
  Serious - Use Alternative (1)ketoprofen will increase the level or effect of seladelpar by decreasing metabolism. Avoid or Use Alternate Drug. OAT3 inhibitors may increase seladelpar systemic exposure.

• sertraline
  Monitor Closely (1)sertraline, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

• Siberian ginseng
  Monitor Closely (1)ketoprofen and Siberian ginseng both increase anticoagulation. Use Caution/Monitor.

• silodosin
  Monitor Closely (1)ketoprofen decreases effects of silodosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• sodium picosulfate/magnesium oxide/anhydrous citric acid
  Monitor Closely (1)ketoprofen, sodium picosulfate/magnesium oxide/anhydrous citric acid. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May be associated with fluid and electrolyte imbalances.

• sodium sulfate/?magnesium sulfate/potassium chloride
  Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of ketoprofen by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

• sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  Monitor Closely (1)ketoprofen, sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol. Other (see comment). Use Caution/Monitor. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance.

• sodium sulfate/potassium sulfate/magnesium sulfate
  Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases toxicity of ketoprofen by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment.

• sotalol
  Monitor Closely (2)ketoprofen decreases effects of sotalol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  sotalol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• sparsentan
  Monitor Closely (1)ketoprofen and sparsentan both increase nephrotoxicity and/or ototoxicity. Use Caution/Monitor. Coadministration of NSAIDS, including selective COX-2 inhibitors, may result in deterioration of kidney function (eg, possible kidney failure). Monitor for signs of worsening renal function with concomitant use with NSAIDs.

• spironolactone
  Monitor Closely (1)spironolactone and ketoprofen both increase serum potassium. Modify Therapy/Monitor Closely.

• streptomycin
  Minor (1)ketoprofen increases levels of streptomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• succinylcholine
  Monitor Closely (1)ketoprofen and succinylcholine both increase serum potassium. Use Caution/Monitor.

• sulfasalazine
  Monitor Closely (2)ketoprofen and sulfasalazine both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and sulfasalazine both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• sulindac
  Monitor Closely (2)ketoprofen and sulindac both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and sulindac both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of sulindac by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• sulopenem etzadroxil/probenecid
  Serious - Use Alternative (1)sulopenem etzadroxil/probenecid increases levels of ketoprofen by decreasing metabolism. Avoid or Use Alternate Drug. Probenecid is an OAT1/3 inhibitor and may increase plasma concentrations of drugs that are dependent on OAT1/3 for elimination.

• tacrolimus
  Serious - Use Alternative (1)ketoprofen, tacrolimus. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. Comment: Concomitant administration increases risk of nephrotoxicity.

• tafluprost
  Monitor Closely (1)tafluprost, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

• telmisartan
  Monitor Closely (3)telmisartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
  ketoprofen decreases effects of telmisartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
  telmisartan and ketoprofen both increase serum potassium. Use Caution/Monitor.

• temocillin
  Monitor Closely (2)temocillin, ketoprofen. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor.
  temocillin, ketoprofen. Either increases levels of the other by decreasing renal clearance. Use Caution/Monitor.

• tenecteplase
  Monitor Closely (1)ketoprofen and tenecteplase both increase anticoagulation. Use Caution/Monitor. Potential for increased risk of bleeding, caution is advised.

• tenofovir DF
  Monitor Closely (1)tenofovir DF, ketoprofen. Either increases levels of the other by decreasing renal clearance. Modify Therapy/Monitor Closely. Toxicity may result from coadministration of tenofovir DF with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered.

• terazosin
  Monitor Closely (1)ketoprofen decreases effects of terazosin by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.

• terbutaline
  Monitor Closely (1)ketoprofen increases and terbutaline decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• ticagrelor
  Monitor Closely (1)ticagrelor, ketoprofen. Either increases effects of the other by anticoagulation. Use Caution/Monitor. Increased risk of bleeding with use of ticagrelor and chronic NSAID use. .

• timolol
  Monitor Closely (2)ketoprofen decreases effects of timolol by pharmacodynamic antagonism. Use Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.
  timolol and ketoprofen both increase serum potassium. Use Caution/Monitor.

• tobramycin
  Minor (1)ketoprofen increases levels of tobramycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in preterm infants.

• tolfenamic acid
  Monitor Closely (2)ketoprofen and tolfenamic acid both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and tolfenamic acid both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of tolfenamic acid by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• tolmetin
  Monitor Closely (2)ketoprofen and tolmetin both increase anticoagulation. Use Caution/Monitor.
  ketoprofen and tolmetin both increase serum potassium. Use Caution/Monitor.Minor (1)ketoprofen will increase the level or effect of tolmetin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• tolvaptan
  Monitor Closely (1)ketoprofen and tolvaptan both increase serum potassium. Use Caution/Monitor.

• torsemide
  Monitor Closely (1)ketoprofen increases and torsemide decreases serum potassium. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• trandolapril
  Monitor Closely (1)trandolapril, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ketoprofen, trandolapril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

• travoprost ophthalmic
  Monitor Closely (1)travoprost ophthalmic, ketoprofen. unspecified interaction mechanism. Use Caution/Monitor. There are conflicting reports from studies of either increased or decreased IOP when ophthalmic prostaglandins are coadministered with NSAIDs (either systemic or ophthalmic).

• trazodone
  Monitor Closely (1)trazodone, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

• triamcinolone acetonide injectable suspension
  Monitor Closely (1)ketoprofen, triamcinolone acetonide injectable suspension. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Concomitant use of NSAIDS and corticosteroids increases the risk of gastrointestinal side effects. .

• triamterene
  Monitor Closely (1)triamterene and ketoprofen both increase serum potassium. Modify Therapy/Monitor Closely.Minor (2)triamterene, ketoprofen. Other (see comment). Minor/Significance Unknown. Comment: Risk of acute renal failure. Mechanism: NSAIDs decrease prostaglandin synthesis, which normally protect against nephrotoxicity.
  ketoprofen increases toxicity of triamterene by pharmacodynamic antagonism. Minor/Significance Unknown. NSAIDs decrease prostaglandin synthesis, increasing the risk of nephrotoxicity.

• valganciclovir
  Minor (1)ketoprofen will increase the level or effect of valganciclovir by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• valsartan
  Monitor Closely (3)valsartan, ketoprofen. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.
  ketoprofen decreases effects of valsartan by pharmacodynamic antagonism. Modify Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect.
  valsartan and ketoprofen both increase serum potassium. Use Caution/Monitor.

• vancomycin
  Minor (1)ketoprofen increases levels of vancomycin by decreasing renal clearance. Minor/Significance Unknown. Interaction mainly occurs in neonates.

• venlafaxine
  Monitor Closely (1)venlafaxine, ketoprofen. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Increased risk of upper GI bleeding. SSRIs inhib. serotonin uptake by platelets.

• vitamin K1 (phytonadione)
  Monitor Closely (1)ketoprofen increases and vitamin K1 (phytonadione) decreases anticoagulation. Effect of interaction is not clear, use caution. Use Caution/Monitor.

• voclosporin
  Monitor Closely (1)voclosporin, ketoprofen. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. Modify Therapy/Monitor Closely. Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity.

• vorapaxar
  Monitor Closely (1)ketoprofen, vorapaxar. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Additive antiplatelet effect may occur.

• vortioxetine
  Monitor Closely (1)ketoprofen, vortioxetine. Either increases effects of the other by anticoagulation. Use Caution/Monitor.

• warfarin
  Monitor Closely (1)ketoprofen, warfarin. Either increases effects of the other by pharmacodynamic synergism. Modify Therapy/Monitor Closely. Drugs with antiplatelet properties may increase anticoagulation effect of warfarin.

• willow bark
  Minor (1)ketoprofen will increase the level or effect of willow bark by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown.

• zanubrutinib
  Monitor Closely (1)ketoprofen, zanubrutinib. Either increases effects of the other by anticoagulation. Modify Therapy/Monitor Closely. Zanubrutinib-induced cytopenias increases risk of hemorrhage. Coadministration of zanubritinib with antiplatelets or anticoagulants may further increase this risk.

• zotepine
  Monitor Closely (1)ketoprofen decreases effects of zotepine by pharmacodynamic antagonism. Use Caution/Monitor. NSAIDs decrease prostaglandin synthesis.