Vivek Keshri | Reva University (original) (raw)

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Papers by Vivek Keshri

Research paper thumbnail of Genome subtraction for the identification of potential antimicrobial targets in Xanthomonas oryzae pv. oryzae PXO99A pathogenic to rice

Research paper thumbnail of Structure Prediction and Binding Site Analysis of Hepatotoxic Microcystin-LR Degrading MlrC-Like Protein from <i>Burkholderia</i> sp. using Computational Approaches

American Journal of Bioinformatics, 2016

Research paper thumbnail of Genome subtraction for the identification of potential antimicrobial targets in Xanthomonas oryzae pv. oryzae PXO99A pathogenic to rice

Research paper thumbnail of Human metallo-β-lactamase enzymes degrade penicillin

Scientific Reports, 2019

Nonribosomal peptides are assemblages, including antibiotics, of canonical amino acids and other ... more Nonribosomal peptides are assemblages, including antibiotics, of canonical amino acids and other molecules. β-lactam antibiotics act on bacterial cell walls and can be cleaved by β-lactamases. β-lactamase activity in humans has been neglected, even though eighteen enzymes have already been annotated such in human genome. Their hydrolysis activities on antibiotics have not been previously investigated. Here, we report that human cells were able to digest penicillin and this activity was inhibited by β-lactamase inhibitor, i.e. sulbactam. Penicillin degradation in human cells was microbiologically demonstrated on Pneumococcus. We expressed a MBLAC2 human β-lactamase, known as an exosome biogenesis enzyme. It cleaved penicillin and was inhibited by sulbactam. Finally, β-lactamases are widely distributed, archaic, and have wide spectrum, including digesting anticancer and β-lactams, that can be then used as nutriments. The evidence of the other MBLAC2 role as a bona fide β-lactamase all...

Research paper thumbnail of The functional convergence of antibiotic resistance in β-lactamases is not conferred by a simple convergent substitution of amino acid

Evolutionary Applications, 2019

Research paper thumbnail of Phylogenomic Analysis of β-Lactamase in Archaea and Bacteria Enables the Identification of Putative New Members

Genome Biology and Evolution, 2018

Research paper thumbnail of Haploview: analysis and visualization of LD and haplotype maps

Bioinformatics, Jan 1, 2005

Knowledge of local linkage disequilibrium (LD) and common haplotype patterns in disease associati... more Knowledge of local linkage disequilibrium (LD) and common haplotype patterns in disease association and positional cloning studies is becoming increasingly widespread since it has become clear (Van Eerdewegh et al., 2002; Rioux et al., 2001; Geesaman et al., 2003; Stoll et al., 2004) ...

Research paper thumbnail of Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum

Journal of …, Jan 1, 2001

Research paper thumbnail of MrBayes 3: Bayesian phylogenetic inference under mixed models

Bioinformatics, Jan 1, 2003

Research paper thumbnail of TAMBIS: transparent access to multiple bioinformatics information sources

Research paper thumbnail of Bioinformatics and the internet

Research paper thumbnail of Taverna: a tool for the composition and enactment of bioinformatics workflows

Research paper thumbnail of Genome subtraction for the identification of potential antimicrobial targets in Xanthomonas oryzae pv. oryzae PXO99A pathogenic to rice

Research paper thumbnail of Structure Prediction and Binding Site Analysis of Hepatotoxic Microcystin-LR Degrading MlrC-Like Protein from <i>Burkholderia</i> sp. using Computational Approaches

American Journal of Bioinformatics, 2016

Research paper thumbnail of Genome subtraction for the identification of potential antimicrobial targets in Xanthomonas oryzae pv. oryzae PXO99A pathogenic to rice

Research paper thumbnail of Human metallo-β-lactamase enzymes degrade penicillin

Scientific Reports, 2019

Nonribosomal peptides are assemblages, including antibiotics, of canonical amino acids and other ... more Nonribosomal peptides are assemblages, including antibiotics, of canonical amino acids and other molecules. β-lactam antibiotics act on bacterial cell walls and can be cleaved by β-lactamases. β-lactamase activity in humans has been neglected, even though eighteen enzymes have already been annotated such in human genome. Their hydrolysis activities on antibiotics have not been previously investigated. Here, we report that human cells were able to digest penicillin and this activity was inhibited by β-lactamase inhibitor, i.e. sulbactam. Penicillin degradation in human cells was microbiologically demonstrated on Pneumococcus. We expressed a MBLAC2 human β-lactamase, known as an exosome biogenesis enzyme. It cleaved penicillin and was inhibited by sulbactam. Finally, β-lactamases are widely distributed, archaic, and have wide spectrum, including digesting anticancer and β-lactams, that can be then used as nutriments. The evidence of the other MBLAC2 role as a bona fide β-lactamase all...

Research paper thumbnail of The functional convergence of antibiotic resistance in β-lactamases is not conferred by a simple convergent substitution of amino acid

Evolutionary Applications, 2019

Research paper thumbnail of Phylogenomic Analysis of β-Lactamase in Archaea and Bacteria Enables the Identification of Putative New Members

Genome Biology and Evolution, 2018

Research paper thumbnail of Haploview: analysis and visualization of LD and haplotype maps

Bioinformatics, Jan 1, 2005

Knowledge of local linkage disequilibrium (LD) and common haplotype patterns in disease associati... more Knowledge of local linkage disequilibrium (LD) and common haplotype patterns in disease association and positional cloning studies is becoming increasingly widespread since it has become clear (Van Eerdewegh et al., 2002; Rioux et al., 2001; Geesaman et al., 2003; Stoll et al., 2004) ...

Research paper thumbnail of Genome sequence and comparative analysis of the solvent-producing bacterium Clostridium acetobutylicum

Journal of …, Jan 1, 2001

Research paper thumbnail of MrBayes 3: Bayesian phylogenetic inference under mixed models

Bioinformatics, Jan 1, 2003

Research paper thumbnail of TAMBIS: transparent access to multiple bioinformatics information sources

Research paper thumbnail of Bioinformatics and the internet

Research paper thumbnail of Taverna: a tool for the composition and enactment of bioinformatics workflows

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