Jorge Sague | RMS Foundation (original) (raw)
Papers by Jorge Sague
Materials, 2010
Varying the polyethyleneglycol spacer between two (iso)-nicotinic groups of the ligand systems, a... more Varying the polyethyleneglycol spacer between two (iso)-nicotinic groups of the ligand systems, a large structural variety of silver coordination compounds was obtained, starting with zero-dimensional ring systems, via one-dimensional chains, helices and double-helices to two-dimensional polycatenanes. Theoretical calculations help to understand their formation and allow predictions in some cases. These structures can be tuned by careful design of the ligand, the use of solvent and the counter ions, influencing also other important properties such as light stability and solubility. The latter is important in the context of biomedical applications, using silver compounds as antimicrobial agents.
Central European Journal of Chemistry, 2008
ABSTRACT Herein, the first example of a co-crystal system formed by an imidazolium nitrate, a car... more ABSTRACT Herein, the first example of a co-crystal system formed by an imidazolium nitrate, a carbene precursor, and copper (II) nitrate, {[Cu(NO3)2(H2O)2]L1(NO3)2} (1) (L1 = 1,1′-dibenzyl-3,3′-butyl-diimidazolium-2,2′-diylidene) is reported. These two building blocks are connected in the solid state through hydrogen bonds to generate a three-dimensional supramolecular network.
The Journal of Supercritical Fluids, 2014
ABSTRACT Recently, the increase in the number of patients who require a hip or knee implant, comb... more ABSTRACT Recently, the increase in the number of patients who require a hip or knee implant, combined with the reduction of age at which this implant is demanded, emphasizes the urgent need for the development of new materials with enhanced mechanical and tribological properties. In this work, a new technique called supercritical in situ precipitation (SCisP) has been employed to manufacture a blend made of ultra-high molecular weight polyethylene with added vitamin E (UHMWPEvit) plus a hyaluronic acid (HA) derivative. The precipitation of the HA derivative within the pores of a porous UHMWPEvit preform allows getting a blend after the post-processing of the SCisP product. Blend characterization results report the reduction of friction coefficient and wear rate in comparison to reference UHMWPEvit, probably due to the improvement in the wettability that hyaluronic derivative produces. Manufacturing times and raw material consumption have been drastically reduced by SCisP in comparison to processes reported up to now. Moreover, preliminary studies varying the conditions of the process, i.e. the type of hyaluronic acid derivative, solvent and number of injections, establish the basis of this technique for further development and open an interesting route in the manufacture of medical devices.
Zeitschrift für anorganische und allgemeine Chemie, 2005
Materials, 2010
Varying the polyethyleneglycol spacer between two (iso)-nicotinic groups of the ligand systems, a... more Varying the polyethyleneglycol spacer between two (iso)-nicotinic groups of the ligand systems, a large structural variety of silver coordination compounds was obtained, starting with zero-dimensional ring systems, via one-dimensional chains, helices and double-helices to two-dimensional polycatenanes. Theoretical calculations help to understand their formation and allow predictions in some cases. These structures can be tuned by careful design of the ligand, the use of solvent and the counter ions, influencing also other important properties such as light stability and solubility. The latter is important in the context of biomedical applications, using silver compounds as antimicrobial agents.
Macromolecular Symposia, 2010
This chapter provides a brief overview on metal ion containing coordination polymer networks, how... more This chapter provides a brief overview on metal ion containing coordination polymer networks, how and why they are made, as an alternative to classical polymers. Our focus will be polymorphism, supramolecular isomerism and pseudopolymorphism. Examples from our group of metal ion containing coordination polymer networks with flexible molecules as building blocks will be highlighted, as they might show parallels with purely organic polymer compounds.
n, L=ethanediyl bis(isonicotinate), n=0, and 2](https://attachments.academia-assets.com/42020314/thumbnails/1.jpg)
](Inorganica Chimica Acta, 2007
The system AgNO 3 and L (L = ethanediyl bis(isonicotinate)) yielded so far five different compoun... more The system AgNO 3 and L (L = ethanediyl bis(isonicotinate)) yielded so far five different compounds from a THF/H 2 O mixture (or acetonitrile) when reacted in a ratio 1:1. Three solvent-free compounds possess the same chemical composition, [Ag(L)NO 3 ], but different structures and thus different properties. Additionally, two solvates [Ag(L)NO 3 ] AE nH 2 O with one or two water molecules have been identified. One of the solvates can be reversibly transformed into one of the solvent free compounds. This clay-like property depends strongly on the structure observed in the solid state, namely on the coordinating function of the nitrate ions with respect to silver cations.
Inorganica Chimica Acta, 2013
ABSTRACT Silver coordination compounds and one-dimensional polymers have been studied, using a li... more ABSTRACT Silver coordination compounds and one-dimensional polymers have been studied, using a linear, flexible N-donor ligand. The solid state structures are well known and show panoply of different structures including a large number of polymorphism, pseudo-polymorphism and isomers. We have studied these structures under the influence of anions, solvents and crystallization conditions, studying also some solution effects. We here present an overview with highlights of some case studies of the synthesis, structures, anion and solvent effects as well as solution behavior during formation of silver coordination polymers. Finally, we will give an outlook on the potential applications of these materials.
Dalton Transactions, 2013
Complexes with silver ions have great potential for applications in medicine. Appropriate bidenta... more Complexes with silver ions have great potential for applications in medicine. Appropriate bidentate ligands, binding to silver ions, are able to generate coordination polymers as well as molecular entities as a function of ligand flexibility, conformation and length. Here we present the continuation of our previous studies in this field with ligands based on oligomers of polyethylene glycol, functionalized at both ends with either nicotinic or isonicotinic acid. The structures of three ligands and nine new coordination compounds are presented. A large variety of structures are obtained as a function of counterion, solvent and ligand-to-metal ratio, such as isolated rings, offset stacked rings, parallel chains and entangled chains, and their antimicrobial properties as well as biocompatibility are assessed.
CrystEngComm, 2006
... Adeline Y. Robin, Jorge L. Sagué and Katharina M. Fromm*. University of Basel, Department of ... more ... Adeline Y. Robin, Jorge L. Sagué and Katharina M. Fromm*. University of Basel, Department of Chemistry, Spitalstrasse 51, CH-4056, Basel, Switzerland. E-mail: katharina.fromm@ unibas.ch; Fax: +41 (0)61/267 1021; Tel: +41 (0)61/267 1004. ...
CrystEngComm, 2008
Herein we report the synthesis and characterization by single crystal X-ray diffraction of three ... more Herein we report the synthesis and characterization by single crystal X-ray diffraction of three new silver(I) complexes {[Ag2$L2](NO3)2(H2O)4} (1), {[Ag2$L2](NO3)2} (2) and {[Ag2$L2](NO3 )2} (3). Whereas compounds 2 and 3 are polymorphs, compound 1 crystallizes as the ...
Crystal Growth & Design, 2006
The two-dimensional structure described here is the first example of a coordination polymer struc... more The two-dimensional structure described here is the first example of a coordination polymer structure consisting of onedimensional polycatenanes fused via silver ions. It can be derived from simple rings consisting of two silver ions and two ligand molecules.
Chemical Communications, 2005
For the first time in Ag coordination chemistry, two supramolecular isomers, a ring and a helix, ... more For the first time in Ag coordination chemistry, two supramolecular isomers, a ring and a helix, are isolated from the same mother liquor as a result of concentration effects.
The Bone & Joint Journal
In search for appropriate materials of potential use to relieve injured articular cartilage, we e... more In search for appropriate materials of potential use to relieve injured articular cartilage, we explored copolymers from HEMA (2-hydroxy-methyl-methacrylate) and MMA (methyl-methacrylate). Such copolymers can be synthesized by thermal or photochemical induced polymerization reaction. The water uptake by swelling to homogeneous hydrogels can easily be controlled by varying the mixing ratio of the hydrophilic (HEMA) and hydrophobic (MMA) monomer, and the nature and amount of added crosslinker (typically EGDA, ethyleneglycol-dimethacrylate). Essentially the same variables strongly influence the mechanical properties, i.e. modulus (stiffness), relaxation response, as well as tribological behavior.The polymer samples were engineered in molds from degassed formulations containing various amounts of HEMA and MMA, 10 % deionized water, and 0.01 % AIBN for thermal polymerization (12 h @ 70°C) or 0.5 % Darocur 1173 (2-hydroxy-2-methyl-1-phenyl-propane-1-one, for photopolymerization, 360 nm UV...
Materials, 2010
Varying the polyethyleneglycol spacer between two (iso)-nicotinic groups of the ligand systems, a... more Varying the polyethyleneglycol spacer between two (iso)-nicotinic groups of the ligand systems, a large structural variety of silver coordination compounds was obtained, starting with zero-dimensional ring systems, via one-dimensional chains, helices and double-helices to two-dimensional polycatenanes. Theoretical calculations help to understand their formation and allow predictions in some cases. These structures can be tuned by careful design of the ligand, the use of solvent and the counter ions, influencing also other important properties such as light stability and solubility. The latter is important in the context of biomedical applications, using silver compounds as antimicrobial agents.
Central European Journal of Chemistry, 2008
ABSTRACT Herein, the first example of a co-crystal system formed by an imidazolium nitrate, a car... more ABSTRACT Herein, the first example of a co-crystal system formed by an imidazolium nitrate, a carbene precursor, and copper (II) nitrate, {[Cu(NO3)2(H2O)2]L1(NO3)2} (1) (L1 = 1,1′-dibenzyl-3,3′-butyl-diimidazolium-2,2′-diylidene) is reported. These two building blocks are connected in the solid state through hydrogen bonds to generate a three-dimensional supramolecular network.
The Journal of Supercritical Fluids, 2014
ABSTRACT Recently, the increase in the number of patients who require a hip or knee implant, comb... more ABSTRACT Recently, the increase in the number of patients who require a hip or knee implant, combined with the reduction of age at which this implant is demanded, emphasizes the urgent need for the development of new materials with enhanced mechanical and tribological properties. In this work, a new technique called supercritical in situ precipitation (SCisP) has been employed to manufacture a blend made of ultra-high molecular weight polyethylene with added vitamin E (UHMWPEvit) plus a hyaluronic acid (HA) derivative. The precipitation of the HA derivative within the pores of a porous UHMWPEvit preform allows getting a blend after the post-processing of the SCisP product. Blend characterization results report the reduction of friction coefficient and wear rate in comparison to reference UHMWPEvit, probably due to the improvement in the wettability that hyaluronic derivative produces. Manufacturing times and raw material consumption have been drastically reduced by SCisP in comparison to processes reported up to now. Moreover, preliminary studies varying the conditions of the process, i.e. the type of hyaluronic acid derivative, solvent and number of injections, establish the basis of this technique for further development and open an interesting route in the manufacture of medical devices.
Zeitschrift für anorganische und allgemeine Chemie, 2005
Materials, 2010
Varying the polyethyleneglycol spacer between two (iso)-nicotinic groups of the ligand systems, a... more Varying the polyethyleneglycol spacer between two (iso)-nicotinic groups of the ligand systems, a large structural variety of silver coordination compounds was obtained, starting with zero-dimensional ring systems, via one-dimensional chains, helices and double-helices to two-dimensional polycatenanes. Theoretical calculations help to understand their formation and allow predictions in some cases. These structures can be tuned by careful design of the ligand, the use of solvent and the counter ions, influencing also other important properties such as light stability and solubility. The latter is important in the context of biomedical applications, using silver compounds as antimicrobial agents.
Macromolecular Symposia, 2010
This chapter provides a brief overview on metal ion containing coordination polymer networks, how... more This chapter provides a brief overview on metal ion containing coordination polymer networks, how and why they are made, as an alternative to classical polymers. Our focus will be polymorphism, supramolecular isomerism and pseudopolymorphism. Examples from our group of metal ion containing coordination polymer networks with flexible molecules as building blocks will be highlighted, as they might show parallels with purely organic polymer compounds.
Inorganica Chimica Acta, 2007
The system AgNO 3 and L (L = ethanediyl bis(isonicotinate)) yielded so far five different compoun... more The system AgNO 3 and L (L = ethanediyl bis(isonicotinate)) yielded so far five different compounds from a THF/H 2 O mixture (or acetonitrile) when reacted in a ratio 1:1. Three solvent-free compounds possess the same chemical composition, [Ag(L)NO 3 ], but different structures and thus different properties. Additionally, two solvates [Ag(L)NO 3 ] AE nH 2 O with one or two water molecules have been identified. One of the solvates can be reversibly transformed into one of the solvent free compounds. This clay-like property depends strongly on the structure observed in the solid state, namely on the coordinating function of the nitrate ions with respect to silver cations.
Inorganica Chimica Acta, 2013
ABSTRACT Silver coordination compounds and one-dimensional polymers have been studied, using a li... more ABSTRACT Silver coordination compounds and one-dimensional polymers have been studied, using a linear, flexible N-donor ligand. The solid state structures are well known and show panoply of different structures including a large number of polymorphism, pseudo-polymorphism and isomers. We have studied these structures under the influence of anions, solvents and crystallization conditions, studying also some solution effects. We here present an overview with highlights of some case studies of the synthesis, structures, anion and solvent effects as well as solution behavior during formation of silver coordination polymers. Finally, we will give an outlook on the potential applications of these materials.
Dalton Transactions, 2013
Complexes with silver ions have great potential for applications in medicine. Appropriate bidenta... more Complexes with silver ions have great potential for applications in medicine. Appropriate bidentate ligands, binding to silver ions, are able to generate coordination polymers as well as molecular entities as a function of ligand flexibility, conformation and length. Here we present the continuation of our previous studies in this field with ligands based on oligomers of polyethylene glycol, functionalized at both ends with either nicotinic or isonicotinic acid. The structures of three ligands and nine new coordination compounds are presented. A large variety of structures are obtained as a function of counterion, solvent and ligand-to-metal ratio, such as isolated rings, offset stacked rings, parallel chains and entangled chains, and their antimicrobial properties as well as biocompatibility are assessed.
CrystEngComm, 2006
... Adeline Y. Robin, Jorge L. Sagué and Katharina M. Fromm*. University of Basel, Department of ... more ... Adeline Y. Robin, Jorge L. Sagué and Katharina M. Fromm*. University of Basel, Department of Chemistry, Spitalstrasse 51, CH-4056, Basel, Switzerland. E-mail: katharina.fromm@ unibas.ch; Fax: +41 (0)61/267 1021; Tel: +41 (0)61/267 1004. ...
CrystEngComm, 2008
Herein we report the synthesis and characterization by single crystal X-ray diffraction of three ... more Herein we report the synthesis and characterization by single crystal X-ray diffraction of three new silver(I) complexes {[Ag2$L2](NO3)2(H2O)4} (1), {[Ag2$L2](NO3)2} (2) and {[Ag2$L2](NO3 )2} (3). Whereas compounds 2 and 3 are polymorphs, compound 1 crystallizes as the ...
Crystal Growth & Design, 2006
The two-dimensional structure described here is the first example of a coordination polymer struc... more The two-dimensional structure described here is the first example of a coordination polymer structure consisting of onedimensional polycatenanes fused via silver ions. It can be derived from simple rings consisting of two silver ions and two ligand molecules.
Chemical Communications, 2005
For the first time in Ag coordination chemistry, two supramolecular isomers, a ring and a helix, ... more For the first time in Ag coordination chemistry, two supramolecular isomers, a ring and a helix, are isolated from the same mother liquor as a result of concentration effects.
The Bone & Joint Journal
In search for appropriate materials of potential use to relieve injured articular cartilage, we e... more In search for appropriate materials of potential use to relieve injured articular cartilage, we explored copolymers from HEMA (2-hydroxy-methyl-methacrylate) and MMA (methyl-methacrylate). Such copolymers can be synthesized by thermal or photochemical induced polymerization reaction. The water uptake by swelling to homogeneous hydrogels can easily be controlled by varying the mixing ratio of the hydrophilic (HEMA) and hydrophobic (MMA) monomer, and the nature and amount of added crosslinker (typically EGDA, ethyleneglycol-dimethacrylate). Essentially the same variables strongly influence the mechanical properties, i.e. modulus (stiffness), relaxation response, as well as tribological behavior.The polymer samples were engineered in molds from degassed formulations containing various amounts of HEMA and MMA, 10 % deionized water, and 0.01 % AIBN for thermal polymerization (12 h @ 70°C) or 0.5 % Darocur 1173 (2-hydroxy-2-methyl-1-phenyl-propane-1-one, for photopolymerization, 360 nm UV...