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About Rosetta Software

For decades, Rosetta has been at the forefront of computational biology, offering groundbreaking capabilities in the modeling, design and analysis of protein structures. Its versatile applications are revolutionizing research and development across various domains. Some of its notable applications include:

• De Novo Protein Design: Rosetta enables the design of proteins from scratch, allowing scientists to create proteins with novel functions that do not exist in nature.
• Enzyme Design: The software is used to design new enzymes or modify the specificity and efficiency of existing enzymes, which can be applied in industrial processes, environmental applications, and the development of new therapeutics.
• Ligand Docking: Rosetta facilitates the prediction of how small molecules, such as potential drugs, bind to proteins. This is crucial for drug discovery and development.
• Macromolecular Complexes: Beyond single proteins, Rosetta helps in understanding the assembly and structure of protein complexes, which are essential for most biological processes.
• Understanding Macromolecular Interactions: It provides insights into how proteins interact with each other, with DNA, RNA, and with small molecules, which is fundamental in all aspects of cell biology and disease.
• Antibody Engineering: The software assists in designing antibodies with improved efficacy and specificity for therapeutic use.
• Vaccine Design: Rosetta has been used to design vaccine candidates by predicting epitopes and how they might elicit an immune response.
• Structure Prediction of Biological Macromolecules: It can predict the three-dimensional structure of proteins and other macromolecules based solely on their amino acid sequence, aiding in the understanding of their function and interaction.
• Biomolecular Materials Design: Rosetta enables the design of novel biomaterials with applications in tissue engineering, biocatalysis, and nanotechnology.

These applications demonstrate Rosetta's versatility and its critical role in advancing research across a wide spectrum of biological and medical sciences.

Rosetta is developed collectively by the Rosetta Commons, a consortium of labs at over 100 institutions globally.