Hanan A Moubarak | Royal Holloway, University of London (original) (raw)
Phone: 07450220404
Address: London
less
Uploads
Papers by Hanan A Moubarak
Background and objective: Cholesterol gallstones are more common in women than men, and exposure ... more Background and objective: Cholesterol gallstones are more common in women than men, and exposure to oral contraceptive steroids and conjugated estrogens increases the risk for cholesterol gallstones. It is hypothesized that estrogen deficiency modifies the expression of an important gene (Sterol-Regulatory Element Binding Protein-2, SREBP-2, gene) involved in hepatic cholesterol regulation through augmenting functions of hepatic estrogen receptor alpha. Therefore, the aim of this study is to investigate molecular mechanisms of how estrogen influences hepatic cholesterol biosynthesis through "estrogen - estrogen receptor subtype alpha – sterol-regulatory element binding protein-2". Design: Three groups of adult female albino rats were included in this study: sham-operated, Ovariectomized, Ovariectomized with estrogen replacement therapy (Estradiol benzoate in a dose of 10 ug/100 gm body weights). Methods: All groups were maintained at optimum environmental temperature with ...
Background and objective: Cholesterol gallstones are more common in women than men, and exposure ... more Background and objective: Cholesterol gallstones are more common in women than men, and exposure to oral contraceptive steroids and conjugated estrogens increases the risk for cholesterol gallstones. It is hypothesized that estrogen deficiency modifies the expression of an important gene (Sterol-Regulatory Element Binding Protein-2, SREBP-2, gene) involved in hepatic cholesterol regulation through augmenting functions of hepatic estrogen receptor alpha. Therefore, the aim of this study is to investigate molecular mechanisms of how estrogen influences hepatic cholesterol biosynthesis through "estrogen - estrogen receptor subtype alpha – sterol-regulatory element binding protein-2". Design: Three groups of adult female albino rats were included in this study: sham-operated, Ovariectomized, Ovariectomized with estrogen replacement therapy (Estradiol benzoate in a dose of 10 ug/100 gm body weights). Methods: All groups were maintained at optimum environmental temperature with ...