Kristin Krueger - Profile on Academia.edu (original) (raw)

Papers by Kristin Krueger

Improving ageing with improvisational theatre

Dietary fats and the APOE-e4 risk allele in relation to cognitive decline: a longitudinal investigation in a biracial population sample

The Journal of nutrition, health & aging/The Journal of nutrition, health and aging, May 1, 2024

Improvisation while Aging

Associations between depressive symptoms, glial fibrillary acid protein, and cognitive decline in a population‐based study

Temporal Patterns of Change in Physical and Cognitive Performance

The Journals of Gerontology: Series A, Dec 9, 2023

Dietary Sugar Intake Associated with a Higher Risk of Dementia in Community-Dwelling Older Adults

Journal of Alzheimer's Disease, Oct 9, 2023

Association of Whole Grain Consumption and Cognitive Decline

Neurology

Background and Objectives To examine the association of whole grain consumption and longitudinal ... more Background and Objectives To examine the association of whole grain consumption and longitudinal change in global cognition, perceptual speed, and episodic memory by different race/ethnicity. Methods We included 3,326 participants from the Chicago Health and Aging Project who responded to a Food Frequency Questionnaire (FFQ), with 2 or more cognitive assessments. Global cognition was assessed using a composite score of episodic memory, perceptual speed, and the Mini Mental State Examination (MMSE). Diet was assessed by a 144-item FFQ. Linear mixed-effects models were used to estimate the association of intakes of whole grains and cognitive decline. Results This study involved 3,326 participants (60.1% African American [AA], 63.7% female) with a mean age of 75 years at baseline and a mean follow-up of 6.1 years. Higher consumption of whole grains was associated with a slower rate of global cognitive decline. Among AA participants, those in the highest quintile of whole grain consumpt...

Archives of General Psychiatry, Feb 1, 2007

Social isolation in old age has been associated with risk of developing dementia, but the risk as... more Social isolation in old age has been associated with risk of developing dementia, but the risk associated with perceived isolation, or loneliness, is not well understood. Objective: To test the hypothesis that loneliness is associated with increased risk of Alzheimer disease (AD). Design: Longitudinal clinicopathologic cohort study with up to 4 years of annual in-home follow-up. Participants: A total of 823 older persons free of dementia at enrollment were recruited from senior citizen facilities in and around Chicago, Ill. Loneliness was assessed with a 5-item scale at baseline (mean±SD, 2.3±0.6) and annually thereafter. At death, a uniform postmortem examination of the brain was conducted to quantify AD pathology in multiple brain regions and the presence of cerebral infarctions. Outcome Measures: Clinical diagnosis of AD and change in previously established composite mea-sures of global cognition and specific cognitive functions. Results: During follow-up, 76 subjects developed clinical AD. Risk of AD was more than doubled in lonely persons (score 3.2, 90th percentile) compared with persons who were not lonely (score 1.4, 10th percentile), and controlling for indicators of social isolation did not affect the finding. Loneliness was associated with lower level of cognition at baseline and with more rapid cognitive decline during follow-up. There was no significant change in loneliness, and mean degree of loneliness during the study was robustly associated with cognitive decline and development of AD. In 90 participants who died and in whom autopsy of the brain was performed, loneliness was unrelated to summary measures of AD pathology or to cerebral infarction. Loneliness is associated with an increased risk of late-life dementia but not with its leading causes.

Research Square (Research Square), May 18, 2023

Little is known about how physical activity in uences the relationship between neuroticism and co... more Little is known about how physical activity in uences the relationship between neuroticism and cognitive function and cognitive decline. Data from the Chicago Health and Aging Project (CHAP) was utilized to conduct this study. CHAP is a population-based cohort study of chronic conditions in older adults. Participants completed in-home interviews cycles of three years from 1993-2012. Mixed effects regression models were conducted to test the associations between physical activity, neuroticism, and the interaction between neuroticism and global cognitive function and global cognitive decline. Strati ed mixed effects regression models by physical activity level were conducted to test the associations between neuroticism and global cognitive function and global cognitive decline. A total of 7,685 participants were eligible for this study. Participants were 62% female and 64% African American. We found statistically signi cant associations for the interaction of medium physical and neuroticism (β = 0.014 (SE = 0.007), p = .037) and the interaction of high physical activity and neuroticism (β = 0.021 (SE = 0.007), p = .003) on global cognitive function at baseline but not for decline over time. Strati ed analysis showed that among participants with high physical activity levels, the association between neuroticism and global cognitive decline was statistically signi cant (β=-0.002 (SE = 0.001), p = .023). Increasing physical activity level bene ts the cognitive functioning of individuals with high neuroticism. Interventions should incorporate health behavior change approaches which aim to reduce characteristics of neuroticism.

JAMA network open, Apr 15, 2022

IMPORTANCE Subjective memory complaints (SMCs) are associated with a faster cognitive decline; wh... more IMPORTANCE Subjective memory complaints (SMCs) are associated with a faster cognitive decline; whether this association is also associated with structural brain alterations, such as white matter hyperintensity (WMH) volumes, requires investigation. To evaluate the association of SMCs with WMH volumes and cognitive decline and investigate the role of WMH volumes in the association between SMCs and cognitive decline. DESIGN, SETTING, AND PARTICIPANTS The Chicago Health and Aging Project, a population-based cohort study, enrolled adults aged 65 years or older. Data collection occurred in 3-year cycles from 1993 until 2012. Our study comprised 975 participants with magnetic resonance imaging assessments, of which 900 participants had data on SMCs and covariates, and 713 participants provided 2 or more cognitive assessments during the follow-up. Statistical analyses were conducted from May to October 2021. EXPOSURES SMCs were obtained from self-reported questionnaire data during clinical evaluations, and the cycle, when reported, constituted the baseline of our study. Based on the frequency and severity of concerns, we categorized participants into 3 groups, (1) no concerns, (2) moderate concerns, and (3) very worried. volume and neuropsychological testing assessments of global cognition. Linear regression analysis was used to investigate the association between SMCs and WMH volumes in a multivariable model adjusted for age, sex, race and ethnicity, education, APOE4 status, and total intracranial volume. The association of SMCs with cognitive decline was investigated using linear mixed-effects models for age, sex, race and ethnicity, education, APOE4 status, follow-up time, and each variable in interaction with time to estimate the annual longitudinal change in cognitive function. Of the 900 participants with data on SMCs, covariates, and WMH volumes, 553 (61.4%) were women, 539 (59.9%) were African American, and the mean (SD) age was 79.5 (6.2) years. SMCs were associated with a larger WMH volume and faster cognitive decline. Compared with participants with no concerns, participants who were very worried had higher WMH volumes (β = 0.833; 95% CI, 0.203-1.463) and 174% faster cognitive decline (β = -0.049; 95% CI, -0.076 to -0.022). The association between SMCs and cognitive decline remained statistically significant among individuals with large WMH volumes (ie, within the fourth quartile). Within the fourth quartile of WMH volumes, participants who were very worried had 428% faster cognitive decline (β = -0.077; 95% CI, -0.144 to -0.011) compared with participants with no concerns. (continued) Key Points Question Are subjective memory complaints (SMCs) associated with cognitive decline because of structural brain alterations, such as white matter hyperintensity (WMH) volumes? Findings In a population-based cohort study of 900 participants with data on SMCs, covariates, and WMH volumes, SMCs were associated with larger WMH volumes and faster cognitive decline. The association of SMCs with cognitive decline was significant among individuals with higher WMH volumes. Meaning This study suggests that SMCs are an important sign of cognitive impairment, especially for individuals with a higher WMH volume.

Properties of the cognitive function battery for the MIND diet intervention to prevent Alzheimer’s disease

Alzheimers & Dementia, Dec 1, 2021

BackgroundOver the last several years, evidence has increasingly demonstrated the strong potentia... more BackgroundOver the last several years, evidence has increasingly demonstrated the strong potential for dietary interventions to improve cognitive function over time. Nonetheless, our ability to measure this progress is limited by variability in cognitive assessments across studies. We evaluated the properties of the cognitive battery used in The MIND Diet Intervention to Prevent Alzheimer’s Disease. The MIND Diet Intervention is a randomized control trial designed to examine the efficacy of the MIND diet to slow cognitive decline and reduce brain atrophy in older adults at risk for Alzheimer’s dementia.MethodParticipants were 604 adults between 65 and 84 years old without cognitive impairment, who had a body mass index > 25 k/m2, a family history of dementia and a suboptimal diet. They had an average of 17 years of education and were mostly white (89%) women (65%). Before randomization into one of two dietary intervention counseling sessions, participants completed an in‐person administration of the MIND cognitive battery of tests. The battery included 12 cognitive tests, measuring the four cognitive domains of executive function, perceptual speed, episodic memory, and semantic memory. We conducted a principal component analysis to examine the consistency between our theoretical domains and statistical performance of participants on each domain. In order to further establish validity of each domain, we regressed the domain scores against the covariates of age, and years of education, and late life cognitive activity.ResultFour factors emerged in the principal component analyses that were similar to the theoretical domains. Rand’s statistic was 0.82 (p<0.001), indicating a good fit between the factor analytic results and the hypothesized grouping. In regression analyses, we found the expected associations with age and late life cognitive activity with each of the four cognitive domains.ConclusionThese results suggest that the MIND cognitive battery is a comprehensive and efficient battery, which may perform well as an outcome measure in future intervention trials for older adults.

Loneliness and cognitive decline in the community: Examining demographic and APOE4 status differences

Alzheimer's & Dementia

Background. Little is known about how physical activity influences the relationship between neuro... more Background. Little is known about how physical activity influences the relationship between neuroticism and cognitive function and cognitive decline.Methods. Data from the Chicago Health and Aging Project (CHAP) was utilized to conduct this study. CHAP is a population-based cohort study of chronic conditions in older adults. Participants completed in-home interviews cycles of three years from 1993–2012. Mixed effects regression models were conducted to test the associations between physical activity, neuroticism, and the interaction between neuroticism and global cognitive function and global cognitive decline. Stratified mixed effects regression models by physical activity level were conducted to test the associations between neuroticism and global cognitive function and global cognitive decline.Results. A total of 7,685 participants were eligible for this study. Participants were 62% female and 64% African American. We found statistically significant associations for the interacti...

Psychologie Française, 2020

that simultaneously measures cognitive, physical, social, and other leisure activities, as well a... more that simultaneously measures cognitive, physical, social, and other leisure activities, as well as sleep, diet, and substance use (alcohol and tobacco). The GLQ and sociodemographic data were collected among 1043 participants, aged 18 to 84. The development, verification of the readability, classification method and data collection are described along this article. Reliability was assessed using Cronbach's alpha coefficient and Intra-Class Correlation coefficient. Validity was tested using correlation coefficients and ANOVAs. Finally, floor and ceiling effects were also verified. Classification of the items within dimensions followed the method proposed by . Results of this study showed that the GLQ had satisfactory psychometric properties. Cronbach's ˛ revealed a weak to good internal consistency (Cronbach's ˛ = .31 to .75). Temporal stability was very good for the general score (ICC = .86) and good to very good for all the dimensions (ICC = .72 to .87). Furthermore, our analyses demonstrated substantial construct validity of the GLQ with more than 75% of the results that were in accordance with hypotheses tests. Finally, floor and ceiling effects also meet satisfactory criteria . Thus, the GLQ is a reliable and valid measure for assessing human engagement in diverse behaviors. As such, this tool may serve as a useful instrument in clinical practice and research involved in understanding how participation in everyday activities influences health, well-being and/or quality of life.

Should Standard Scores Be Adjusted for the Level of Education?

PsycEXTRA Dataset

Archives of Clinical Neuropsychology, 2009

The Spanish version of the third edition of the Wechsler Adult Intelligence Scale (WAIS-III) by T... more The Spanish version of the third edition of the Wechsler Adult Intelligence Scale (WAIS-III) by TEA Ediciones is an excellent addition to available instruments for Spanish speakers. The Spanish norms function similarly to US norms for individuals aged 16-35. The norms become increasingly different for individuals 35 and older, seemingly because of the lower levels of formal education of the older Spanish cohorts. Using data from a random half of the Spanish sample, the authors developed regression equations to adjust the scaled scores for individuals with a low level of education. The adjustment is made to the level that would have been expected if the individual had 12 years of education, the median level of education of the US norms. The article includes the methodology and values necessary to make the adjustments. The scaled scores were then adjusted for individuals on the second random half of the Spanish sample and compared to the United States norms. The results showed the adjustments succeed in bringing the Spanish norms closer to the US norms.

P2‐117: Traumatic brain injury and risk of dementia in older veterans

Alzheimer's & Dementia, 2011

ABSTRACT Traumatic brain injury (TBI) is common in military personnel, and there is growing conce... more ABSTRACT Traumatic brain injury (TBI) is common in military personnel, and there is growing concern about the long-term effects of TBI on the brain; however, few studies have examined the association between TBI and risk of dementia in veterans.METHODS: We performed a retrospective cohort study of 188,764 US veterans aged 55 years or older who had at least one inpatient or outpatient visit during both the baseline (2000-2003) and follow-up (2003-2012) periods and did not have a dementia diagnosis at baseline. TBI and dementia diagnoses were determined using ICD-9 codes in electronic medical records. Fine-Gray proportional hazards models were used to determine whether TBI was associated with greater risk of incident dementia, accounting for the competing risk of death and adjusting for demographics, medical comorbidities, and psychiatric disorders.RESULTS: Veterans were a mean age of 68 years at baseline. During the 9-year follow-up period, 16% of those with TBI developed dementia compared with 10% of those without TBI (adjusted hazard ratio, 1.57; 95% confidence interval: 1.35-1.83). There was evidence of an additive association between TBI and other conditions on risk of dementia.CONCLUSIONS: TBI in older veterans was associated with a 60% increase in the risk of developing dementia over 9 years after accounting for competing risks and potential confounders. Our results suggest that TBI in older veterans may predispose toward development of symptomatic dementia and raise concern about the potential long-term consequences of TBI in younger veterans and civilians.

Alzheimer Disease & Associated Disorders, 2009

Researchers from Alzheimer's Disease Centers (ADCs) across the United States with expertise in th... more Researchers from Alzheimer's Disease Centers (ADCs) across the United States with expertise in the assessment of Spanish-speaking elderly collaborated to create the official Spanish version of measures in the Uniform Data Set of the National Institute on Aging Alzheimer's Disease Center Program. The present article describes this project, whose primary goal was to create Spanish instruments with cultural and linguistic equivalence to the English versions. The resulting Spanish versions make provisions for variations among Spanish-speaking groups in the United States of different nationalities, socio-cultural, linguistic, and educational backgrounds. A consensus-based translation and adaptation approach was used, and guiding principles and specific components of this process are summarized. The Spanish translation and adaptation of the Uniform Data Set measures became available online to ADCs in April 2007. Its creation is important, as the resulting effort provides standardized measures for the collection of cross-sectional and longitudinal data on a large cohort of Spanish-speaking elders across the country and facilitates collaborative research among ADCs.

Neuroepidemiology

Background: More frequent engagement in cognitive activity is associated with better cognitive fu... more Background: More frequent engagement in cognitive activity is associated with better cognitive function in older adults, but the mechanism of action is not fully understood. Debate remains whether increased cognitive activity provides a meaningful benefit for cognitive health or if decreased cognitive activity represents a prodrome of cognitive impairment. Neurological biomarkers provide a novel way to examine this relationship in the context of cognitive aging. Methods: We examined the association of self-reported cognitive activity, cognitive function, and concentrations of three biomarkers in community-dwelling participants of a longitudinal, population-based study. Cognitive activity was measured at baseline by asking participants to rate the frequency of 7 activities: (1) viewing television, (2) listening to the radio, (3) visiting a museum, (4) playing games, such as cards, checkers, crosswords, or other puzzles or games, (5) reading books, (6) reading magazines, and (7) readi...

White matter hyperintensity, neurofilament light chain, and cognitive decline

Annals of Clinical and Translational Neurology