Thomas Berlage | RWTH Aachen University (original) (raw)
Papers by Thomas Berlage
Vol 3: Recent Advances, 2005
Decision support for planning and improving software development projects is a crucial success fa... more Decision support for planning and improving software development projects is a crucial success factor. The special characteristics of software development aggregate these tasks in contrast to the planning of many other processes, such as production processes. Process simulation can be used to support decisions on process alternatives on the basis of existing knowledge. Thereby, new development knowledge can be gained faster and more cost-effectively. This chapter gives a short introduction to experimental software engineering, describes simulation approaches within that area, and introduces a method for systematically developing discrete-event software process simulation models. Advanced simulation modeling techniques will point out key problems and possible solutions, including the use of visualization techniques for better simulation result interpretation.
Skin Research and Technology, 2011
To automatically assess hair growth during cosmetic trials, incorporating parameters such as anag... more To automatically assess hair growth during cosmetic trials, incorporating parameters such as anagen-to-telogen rate, growth rate, and especially hair diameter. We designed and qualified a new and automatic phototrichogram system based on a high-resolution DSLR camera system (theoretical resolution of 2.557 μm/pixel) and modular macrolens system with fixed focus, combined with a trainable pattern recognition software for automated analysis. We improved the standard routine for dermatological phototrichogram technique to overcome inaccuracy in thickness measurements due to hair swelling by using an alternative immersion fluid, and increased the effective resolution for hair size and thickness measurement to <4 μm. After having qualified manual measurements as gold standard for the determination of hair diameters, we established a new trainable automatic picture analysis software able to locate and measure individual hairs in length and thickness even in picture series taken from the same skin area at different time points. Comparisons between manual and automatic measurements of the same hairs showed a >90% correlation, and by comparing the automatic results with manual measurements of the same images without individual hair annotation, we could find a correlation of at least 80%. According to the results and findings generated in this qualification study, we have a reliable tool now that enables us to test cosmetic products for hair treatment in a highly automated way with a sufficient degree of precision and accuracy to detect even small changes in hair diameter during cosmetic trials.
International Congress Series, 2001
... Thomas Berlage a , Corresponding Author Contact Information , E-mail The Corresponding Author... more ... Thomas Berlage a , Corresponding Author Contact Information , E-mail The Corresponding Author ,Arno Schmitgen a , Christoph Schmitz b and Armin Welz b. ... 4. N. Bruining, IP Kay, G. Grunst, T. Berlage, J. Waldinger, B. Mumm and J. Roelandt, Virtual reality guides image ...
Proceedings of the Ifip Tc2 Wg2 7 Working Conference on Engineering For Human Computer Interaction, 1992
... The GINA Interaction Recorder. ...
Proceedings of the Third IEEE International Conference on Multimedia Computing and Systems, 1996
... Bonn and Cologne, manufacturers of ultrasonic devices and companies offering medical training... more ... Bonn and Cologne, manufacturers of ultrasonic devices and companies offering medical training, the project has developed modules that can be operated as a standalone tutoring and on-linetraining system. The modules will also be integrated into future ultrasound scanners. ...
European Journal of Medical Research, 2014
Computers & Geosciences, 2014
ABSTRACT
In commercials and motion pictures, computer graphics is often used to achieve special effects, e... more In commercials and motion pictures, computer graphics is often used to achieve special effects, e.g., adding synthetic dinosaurs in "Jurassic Park". This process usually implies special camera equipment and a careful and time consuming post processing of single frames. We consider a simplified scenario, where synthetic objects are added automatically to a live scene in real-time. Reference points are identified interactively in the first image and tracked in the image sequence in realtime.
In commercials and motion pictures, computer graphics is often used to achieve special effects, e... more In commercials and motion pictures, computer graphics is often used to achieve special effects, e.g., adding synthetic dinosaurs in "Jurassic Park". This process usually implies special camera equipment and a careful and time consuming post processing of single frames. We consider a simplified scenario, where synthetic objects are added automatically to a live scene in real-time. Reference points are identified interactively in the first image and tracked in the image sequence in realtime. The camera settings including the camera position are calculated from these points. Therefore, a shot with moving camera can be handled which cannot be done satisfactorily with other current systems. The camera data is used for generating the appropriately transformed synthetic object at the correct place in the video. The whole process has to be performed within the video cycle of 1/25 sec which asks for specially op...
Lecture Notes in Computer Science, 1999
ABSTRACT . LOCALITE is a frameless neuronavigation system that particularlyaddresses a problem wi... more ABSTRACT . LOCALITE is a frameless neuronavigation system that particularlyaddresses a problem with currentinterventional magnetic resonanceimaging #iMRI# systems: non-interactive response time in theinteractive scan mode and poor image quality with fast scanning sequences.LOCALITE calculates image planes selected via a handheld localizerfrom preor intra-operativevolume data sets. This approach provides areally interactive localizer device with high quality images. The volumedata are...
Proceedings of the 9th annual ACM symposium on User interface software and technology - UIST '96, 1996
FOCUS, the Feature-Oriented Catalog USer interface, is an interactive table viewer for a common k... more FOCUS, the Feature-Oriented Catalog USer interface, is an interactive table viewer for a common kind of table, namely the object-attribute table, also called cases-by-attribute table or relational table. Typical examples of these tables are the Roll Calls in BYTE where the features and test results of a family of hardware or software products are compared. FOCUS supports data exploration by a combination of a focus+context or fisheye technique, a hierarchical outliner for large attribute sets, and a general and easy-to-use dynamic query mechanism where the user simply clicks on desired values found in the table. A PC/Windows implementation of FOCUS is publicly available (http://www.gmd.
Computers in Cardiology 1997, 1997
The CardiAssist project under the Health Telematics program of the EU aims at the support of card... more The CardiAssist project under the Health Telematics program of the EU aims at the support of cardiac diagnosis and telecooperation, where ultrasound images play a major role. The consortium consists of manufacturers of ultrasound scanners, research partners and medical universities: I GMD, German national research center for 2 Vingmed Sound, ultrasound manufacturer 3 4 University of Trondheim, SINTEFDDT 5 University Bonn, Kinderklinik 6 University Lisbon 7 The project uses a three-fold approach: information technology TomTec, manufacturer of workstation software for 3 -0 rendering Thoraxcenter / Erasmus University Rotterdam Improving the quality of 3 0 ultrasound images Integrating an enabling system to impart an in-depth understanding of cardiac diseases through interactive 3 0 graphics and animation Using 3 0 ultrasound images together with a corresponding model and a variety of annotations and references as a communication medium between health care professionals (cardiologists, surgeons).
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011
Microscopic images of tissue sections are used for diagnosis and monitoring of therapy, by analys... more Microscopic images of tissue sections are used for diagnosis and monitoring of therapy, by analysis of protein patterns correlating to disease states. Spatial protein distribution is influenced by protein translocation between different membrane compartments and quantified by comparison of microscopic images of biological samples. Cholestatic liver diseases are characterized by translocation of transport proteins, and quantification of their dislocation offers new diagnostic options. However, reliable and unbiased tools are lacking. The nowadays used manual method is slow, subjective and errorprone. We have developed a new workflow based on automated image analysis and improved it by the introduction of scalefree descriptors for the translocation quantification. This fast and unbiased method can substitute the manual analysis, and the suggested descriptors perform better than the earlier used statistical variance.
Biomedical Engineering, 2011
ABSTRACT Many dynamic cellular processes are associated with intra- and intercellular translocati... more ABSTRACT Many dynamic cellular processes are associated with intra- and intercellular translocation of proteins. Several proteins are responsible for the active transport across the membrane of liver cells. For example, bile salts are exported from hepatocytes into adjacent canaliculi by transporter proteins embedded in the membrane. Under hyperosmotic conditions they are retrieved into intracellular vesicles and transport is down regulated. The location of these transporters can be explored by fluorescence microscopy. A toponomic analysis of the hepatic transporters may reveal functional information of clinical relevance and serve as an example of other location-regulated processes. An automated method was developed which quantifies the localisation of transporter proteins in a cell. Laser scanning confocal microscopy images were analysed for suitable membrane segments by automatic image processing. Protein distribution profiles across the membrane were obtained and quantified. Rat liver tissue samples incubated under normal and hyperosmotic conditions were compared. The fully automated workflow for the information extraction and statistical evaluation has been elaborated and produces robust results. Slow manual calculation can be substituted by the faster and completely automated method. Furthermore, the new method only uses objective and reproducible criteria. Robustness and stable performance have been shown on various data sets.
Proceedings of the IFIP TC2/WG2. 7 Working …, 1992
... The GINA Interaction Recorder. ...
Journal of the American Society of Echocardiography, 2005
Two-dimensional (2D) echocardiography is a userdependant technique that poses some inherent probl... more Two-dimensional (2D) echocardiography is a userdependant technique that poses some inherent problems to the beginner. The first problem for beginners is spatial orientation, especially the orientation of the scan plane in reference to the 3-dimensional (3D) geometry of the heart. The second problem for beginners is steering of the ultrasound probe. We have designed a simulator to teach these skills. On a computer screen a side-by-side presentation of a 3D virtual reality scene on the right side and a 2D echocardiographic view on the left side is given. The virtual scene consists of a 3D heart and an ultrasound probe with scan plane. The 2D echocardiographic image is calculated from 3D echocardio-
Journal of Geophysics and Engineering, 2007
Electrical borehole wall images represent grey-level-coded micro-resistivity measurements at the ... more Electrical borehole wall images represent grey-level-coded micro-resistivity measurements at the borehole wall. Different scientific methods have been implemented to transform image data into quantitative log curves. We introduce a pattern recognition technique applying texture analysis, which uses second-order statistics based on studying the occurrence of pixel pairs. We calculate so-called Haralick texture features such as contrast, energy, entropy and homogeneity. The supervised classification method is used for assigning characteristic texture features to different rock classes and assessing the discriminative power of these image features. We use classifiers obtained from training intervals to characterize the entire image data set recovered in ODP hole 1203A. This yields a synthetic lithology profile based on computed texture data. We show that Haralick features accurately classify 89.9% of the training intervals. We obtained misclassification for vesicular basaltic rocks. Hence, further image analysis tools are used to improve the classification reliability. We decompose the 2D image signal by the application of wavelet transformation in order to enhance image objects horizontally, diagonally and vertically. The resulting filtered images are used for further texture analysis. This combined classification based on Haralick features and wavelet transformation improved our classification up to a level of 98%. The application of wavelet transformation increases the consistency between standard logging profiles and texture-derived lithology. Texture analysis of borehole wall images offers the potential to facilitate objective analysis of multiple boreholes with the same lithology.
Vol 3: Recent Advances, 2005
Decision support for planning and improving software development projects is a crucial success fa... more Decision support for planning and improving software development projects is a crucial success factor. The special characteristics of software development aggregate these tasks in contrast to the planning of many other processes, such as production processes. Process simulation can be used to support decisions on process alternatives on the basis of existing knowledge. Thereby, new development knowledge can be gained faster and more cost-effectively. This chapter gives a short introduction to experimental software engineering, describes simulation approaches within that area, and introduces a method for systematically developing discrete-event software process simulation models. Advanced simulation modeling techniques will point out key problems and possible solutions, including the use of visualization techniques for better simulation result interpretation.
Skin Research and Technology, 2011
To automatically assess hair growth during cosmetic trials, incorporating parameters such as anag... more To automatically assess hair growth during cosmetic trials, incorporating parameters such as anagen-to-telogen rate, growth rate, and especially hair diameter. We designed and qualified a new and automatic phototrichogram system based on a high-resolution DSLR camera system (theoretical resolution of 2.557 μm/pixel) and modular macrolens system with fixed focus, combined with a trainable pattern recognition software for automated analysis. We improved the standard routine for dermatological phototrichogram technique to overcome inaccuracy in thickness measurements due to hair swelling by using an alternative immersion fluid, and increased the effective resolution for hair size and thickness measurement to <4 μm. After having qualified manual measurements as gold standard for the determination of hair diameters, we established a new trainable automatic picture analysis software able to locate and measure individual hairs in length and thickness even in picture series taken from the same skin area at different time points. Comparisons between manual and automatic measurements of the same hairs showed a >90% correlation, and by comparing the automatic results with manual measurements of the same images without individual hair annotation, we could find a correlation of at least 80%. According to the results and findings generated in this qualification study, we have a reliable tool now that enables us to test cosmetic products for hair treatment in a highly automated way with a sufficient degree of precision and accuracy to detect even small changes in hair diameter during cosmetic trials.
International Congress Series, 2001
... Thomas Berlage a , Corresponding Author Contact Information , E-mail The Corresponding Author... more ... Thomas Berlage a , Corresponding Author Contact Information , E-mail The Corresponding Author ,Arno Schmitgen a , Christoph Schmitz b and Armin Welz b. ... 4. N. Bruining, IP Kay, G. Grunst, T. Berlage, J. Waldinger, B. Mumm and J. Roelandt, Virtual reality guides image ...
Proceedings of the Ifip Tc2 Wg2 7 Working Conference on Engineering For Human Computer Interaction, 1992
... The GINA Interaction Recorder. ...
Proceedings of the Third IEEE International Conference on Multimedia Computing and Systems, 1996
... Bonn and Cologne, manufacturers of ultrasonic devices and companies offering medical training... more ... Bonn and Cologne, manufacturers of ultrasonic devices and companies offering medical training, the project has developed modules that can be operated as a standalone tutoring and on-linetraining system. The modules will also be integrated into future ultrasound scanners. ...
European Journal of Medical Research, 2014
Computers & Geosciences, 2014
ABSTRACT
In commercials and motion pictures, computer graphics is often used to achieve special effects, e... more In commercials and motion pictures, computer graphics is often used to achieve special effects, e.g., adding synthetic dinosaurs in "Jurassic Park". This process usually implies special camera equipment and a careful and time consuming post processing of single frames. We consider a simplified scenario, where synthetic objects are added automatically to a live scene in real-time. Reference points are identified interactively in the first image and tracked in the image sequence in realtime.
In commercials and motion pictures, computer graphics is often used to achieve special effects, e... more In commercials and motion pictures, computer graphics is often used to achieve special effects, e.g., adding synthetic dinosaurs in "Jurassic Park". This process usually implies special camera equipment and a careful and time consuming post processing of single frames. We consider a simplified scenario, where synthetic objects are added automatically to a live scene in real-time. Reference points are identified interactively in the first image and tracked in the image sequence in realtime. The camera settings including the camera position are calculated from these points. Therefore, a shot with moving camera can be handled which cannot be done satisfactorily with other current systems. The camera data is used for generating the appropriately transformed synthetic object at the correct place in the video. The whole process has to be performed within the video cycle of 1/25 sec which asks for specially op...
Lecture Notes in Computer Science, 1999
ABSTRACT . LOCALITE is a frameless neuronavigation system that particularlyaddresses a problem wi... more ABSTRACT . LOCALITE is a frameless neuronavigation system that particularlyaddresses a problem with currentinterventional magnetic resonanceimaging #iMRI# systems: non-interactive response time in theinteractive scan mode and poor image quality with fast scanning sequences.LOCALITE calculates image planes selected via a handheld localizerfrom preor intra-operativevolume data sets. This approach provides areally interactive localizer device with high quality images. The volumedata are...
Proceedings of the 9th annual ACM symposium on User interface software and technology - UIST '96, 1996
FOCUS, the Feature-Oriented Catalog USer interface, is an interactive table viewer for a common k... more FOCUS, the Feature-Oriented Catalog USer interface, is an interactive table viewer for a common kind of table, namely the object-attribute table, also called cases-by-attribute table or relational table. Typical examples of these tables are the Roll Calls in BYTE where the features and test results of a family of hardware or software products are compared. FOCUS supports data exploration by a combination of a focus+context or fisheye technique, a hierarchical outliner for large attribute sets, and a general and easy-to-use dynamic query mechanism where the user simply clicks on desired values found in the table. A PC/Windows implementation of FOCUS is publicly available (http://www.gmd.
Computers in Cardiology 1997, 1997
The CardiAssist project under the Health Telematics program of the EU aims at the support of card... more The CardiAssist project under the Health Telematics program of the EU aims at the support of cardiac diagnosis and telecooperation, where ultrasound images play a major role. The consortium consists of manufacturers of ultrasound scanners, research partners and medical universities: I GMD, German national research center for 2 Vingmed Sound, ultrasound manufacturer 3 4 University of Trondheim, SINTEFDDT 5 University Bonn, Kinderklinik 6 University Lisbon 7 The project uses a three-fold approach: information technology TomTec, manufacturer of workstation software for 3 -0 rendering Thoraxcenter / Erasmus University Rotterdam Improving the quality of 3 0 ultrasound images Integrating an enabling system to impart an in-depth understanding of cardiac diseases through interactive 3 0 graphics and animation Using 3 0 ultrasound images together with a corresponding model and a variety of annotations and references as a communication medium between health care professionals (cardiologists, surgeons).
2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, 2011
Microscopic images of tissue sections are used for diagnosis and monitoring of therapy, by analys... more Microscopic images of tissue sections are used for diagnosis and monitoring of therapy, by analysis of protein patterns correlating to disease states. Spatial protein distribution is influenced by protein translocation between different membrane compartments and quantified by comparison of microscopic images of biological samples. Cholestatic liver diseases are characterized by translocation of transport proteins, and quantification of their dislocation offers new diagnostic options. However, reliable and unbiased tools are lacking. The nowadays used manual method is slow, subjective and errorprone. We have developed a new workflow based on automated image analysis and improved it by the introduction of scalefree descriptors for the translocation quantification. This fast and unbiased method can substitute the manual analysis, and the suggested descriptors perform better than the earlier used statistical variance.
Biomedical Engineering, 2011
ABSTRACT Many dynamic cellular processes are associated with intra- and intercellular translocati... more ABSTRACT Many dynamic cellular processes are associated with intra- and intercellular translocation of proteins. Several proteins are responsible for the active transport across the membrane of liver cells. For example, bile salts are exported from hepatocytes into adjacent canaliculi by transporter proteins embedded in the membrane. Under hyperosmotic conditions they are retrieved into intracellular vesicles and transport is down regulated. The location of these transporters can be explored by fluorescence microscopy. A toponomic analysis of the hepatic transporters may reveal functional information of clinical relevance and serve as an example of other location-regulated processes. An automated method was developed which quantifies the localisation of transporter proteins in a cell. Laser scanning confocal microscopy images were analysed for suitable membrane segments by automatic image processing. Protein distribution profiles across the membrane were obtained and quantified. Rat liver tissue samples incubated under normal and hyperosmotic conditions were compared. The fully automated workflow for the information extraction and statistical evaluation has been elaborated and produces robust results. Slow manual calculation can be substituted by the faster and completely automated method. Furthermore, the new method only uses objective and reproducible criteria. Robustness and stable performance have been shown on various data sets.
Proceedings of the IFIP TC2/WG2. 7 Working …, 1992
... The GINA Interaction Recorder. ...
Journal of the American Society of Echocardiography, 2005
Two-dimensional (2D) echocardiography is a userdependant technique that poses some inherent probl... more Two-dimensional (2D) echocardiography is a userdependant technique that poses some inherent problems to the beginner. The first problem for beginners is spatial orientation, especially the orientation of the scan plane in reference to the 3-dimensional (3D) geometry of the heart. The second problem for beginners is steering of the ultrasound probe. We have designed a simulator to teach these skills. On a computer screen a side-by-side presentation of a 3D virtual reality scene on the right side and a 2D echocardiographic view on the left side is given. The virtual scene consists of a 3D heart and an ultrasound probe with scan plane. The 2D echocardiographic image is calculated from 3D echocardio-
Journal of Geophysics and Engineering, 2007
Electrical borehole wall images represent grey-level-coded micro-resistivity measurements at the ... more Electrical borehole wall images represent grey-level-coded micro-resistivity measurements at the borehole wall. Different scientific methods have been implemented to transform image data into quantitative log curves. We introduce a pattern recognition technique applying texture analysis, which uses second-order statistics based on studying the occurrence of pixel pairs. We calculate so-called Haralick texture features such as contrast, energy, entropy and homogeneity. The supervised classification method is used for assigning characteristic texture features to different rock classes and assessing the discriminative power of these image features. We use classifiers obtained from training intervals to characterize the entire image data set recovered in ODP hole 1203A. This yields a synthetic lithology profile based on computed texture data. We show that Haralick features accurately classify 89.9% of the training intervals. We obtained misclassification for vesicular basaltic rocks. Hence, further image analysis tools are used to improve the classification reliability. We decompose the 2D image signal by the application of wavelet transformation in order to enhance image objects horizontally, diagonally and vertically. The resulting filtered images are used for further texture analysis. This combined classification based on Haralick features and wavelet transformation improved our classification up to a level of 98%. The application of wavelet transformation increases the consistency between standard logging profiles and texture-derived lithology. Texture analysis of borehole wall images offers the potential to facilitate objective analysis of multiple boreholes with the same lithology.