Dr. Mzgin mohammed ayoob | Salahaddin University-Erbil (original) (raw)
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Papers by Dr. Mzgin mohammed ayoob
Inorganic Chemistry Communication , 2023
In this study, a novel series of pyrimidine compounds featuring azo linkages was synthesized via ... more In this study, a novel series of pyrimidine compounds featuring azo linkages was synthesized via a sequence of stepwise and one-pot three-component reactions. The synthetic process commenced with the diazotization of 3chloro-4-methyl aniline, followed bycoupling reaction with 4-hydroxy acetophenone, yielding the azo molecule denoted as 1-(3-((3-chloro-4-methylphenyl)diazenyl)-4-hydroxyphenyl)ethan-1-one. Subsequently, this compound underwent benzylation with benzyl bromide by Williamson ether synthesis, leading to the formation of 1-(4-(benzyloxy)-3-((3-chloro-4-methylphenyl)diazenyl)phenyl)ethan-1-one. The resultant azo-benzyloxy compound was then subjected to both classical and one-pot methodologies to synthesize pyrimidine derivatives, from results obtained from one pot reaction were in good yield. Structural elucidation of the newly synthesized compounds was characterized by spectral analysis, including FT-IR, 1 H NMR, 13 C NMR, and 13 C-DEPT-135-NMR. The spectroscopic data confirmed the integrity of the molecular structures. Lastly, certain pyrimidine derivatives were evaluated for their antimicrobial activity against two strains of bacteria, namely Staphylococcus aureus and Escherichia coli. The results revealed that as the increasing of concentration, the sensitivity increased as reached 800 µg /mL no growth of bacterial was seen, It is also notable that the synthesized compounds have antimicrobial efficacy against both bacterial types.
Egyptian Journal of Chemistry
In this study, novel benzamide derivatives were synthesized from the ring opening of benzoxazin-4... more In this study, novel benzamide derivatives were synthesized from the ring opening of benzoxazin-4-one in conduction with primary aromatic amines in relatively short reaction durations (1-5) minutes. In just a few minutes, sulphuric acid was utilized to cyclodehydration of benzamide derivatives into quinazolinones intramolecularly. FT-IR, 1H-NMR, 13C-NMR, and DEPT-135-13C-NMR were used to characterize the structure of newly synthesized compounds, and single crystal X-Ray was used to confirm the structure of compound 3a. The synthesized compounds were shown to have potent antibacterial activity against microorganisms, and a molecular docking analysis revealed a favorable binding contact with the target bacterial DNA gyrase (PDB ID: 1KZN) of S. aureus. Furthermore, in silico ADMET calculations were performed for all synthesized compounds that showed promise when compared to conventional ciprofloxacin.
AIP Conference Proceedings, 2017
Green synthesis of chalcones derivatives as intermediate of flavones and their antibacterial acti... more Green synthesis of chalcones derivatives as intermediate of flavones and their antibacterial activities
![Research paper thumbnail of Crystal structure of (6E,20E)-3,24-di-fluoro-13,14,28,29-tetra-hydro-5H,22H-tetra-benzo[e,j,p,u][1,4,12,15]tetra-oxa-cyclo-docosine-5,22-dione](https://attachments.academia-assets.com/73508509/thumbnails/1.jpg)
](Acta crystallographica. Section E, Crystallographic communications, 2017
The conformation of the title compound, C34H26F2O6, is cone-shaped, partially determined by intra... more The conformation of the title compound, C34H26F2O6, is cone-shaped, partially determined by intra-molecular C-H⋯O short contacts. The benzene rings at the top of the cone are inclined to one another by 73.10 (7)°, while the benzene rings at the bottom of the cone are inclined to one another by 35.49 (8)°. In the crystal, mol-ecules are linked by C-H⋯O and C-H⋯F hydrogen bonds, forming a three-dimensional supra-molecular structure. There are also C-H⋯π contacts present within the framework structure.
AIP Conference Proceedings, 2017
In the present study; 5-(4-chlorophenyl azo)-2-hydroxy acetophenone (1) was prepared by diazotiza... more In the present study; 5-(4-chlorophenyl azo)-2-hydroxy acetophenone (1) was prepared by diazotization of 4-chloro aniline and its coupling reaction with 2-hydroxy acetophenone, then reacted with different azo benzyloxy benzaldehydes(3a-i) to give new synthesized 2-hydroxy chalcones(4a-i). The later compounds were subjected to oxidative cyclization by catalytic amount of I 2 in DMSO affording the target molecules new flavones bearing two azo-linkages (5a-i). The structures of the newly synthesized compounds were identified on the bases of their FT-IR, 1 H-NMR, 13 C-NMR and DEPT-135 spectra. The synthesized Flavone derivatives were evaluated against two types of bacteria gram positive (Staphylococcus aurous) and gram negative (Pseudomonas aeruginosa). The results showed that most of the synthesized flavones are more sensitive against (G-ve) bacteria than (G +ve) bacteria.
Inorganic Chemistry Communication , 2023
In this study, a novel series of pyrimidine compounds featuring azo linkages was synthesized via ... more In this study, a novel series of pyrimidine compounds featuring azo linkages was synthesized via a sequence of stepwise and one-pot three-component reactions. The synthetic process commenced with the diazotization of 3chloro-4-methyl aniline, followed bycoupling reaction with 4-hydroxy acetophenone, yielding the azo molecule denoted as 1-(3-((3-chloro-4-methylphenyl)diazenyl)-4-hydroxyphenyl)ethan-1-one. Subsequently, this compound underwent benzylation with benzyl bromide by Williamson ether synthesis, leading to the formation of 1-(4-(benzyloxy)-3-((3-chloro-4-methylphenyl)diazenyl)phenyl)ethan-1-one. The resultant azo-benzyloxy compound was then subjected to both classical and one-pot methodologies to synthesize pyrimidine derivatives, from results obtained from one pot reaction were in good yield. Structural elucidation of the newly synthesized compounds was characterized by spectral analysis, including FT-IR, 1 H NMR, 13 C NMR, and 13 C-DEPT-135-NMR. The spectroscopic data confirmed the integrity of the molecular structures. Lastly, certain pyrimidine derivatives were evaluated for their antimicrobial activity against two strains of bacteria, namely Staphylococcus aureus and Escherichia coli. The results revealed that as the increasing of concentration, the sensitivity increased as reached 800 µg /mL no growth of bacterial was seen, It is also notable that the synthesized compounds have antimicrobial efficacy against both bacterial types.
Egyptian Journal of Chemistry
In this study, novel benzamide derivatives were synthesized from the ring opening of benzoxazin-4... more In this study, novel benzamide derivatives were synthesized from the ring opening of benzoxazin-4-one in conduction with primary aromatic amines in relatively short reaction durations (1-5) minutes. In just a few minutes, sulphuric acid was utilized to cyclodehydration of benzamide derivatives into quinazolinones intramolecularly. FT-IR, 1H-NMR, 13C-NMR, and DEPT-135-13C-NMR were used to characterize the structure of newly synthesized compounds, and single crystal X-Ray was used to confirm the structure of compound 3a. The synthesized compounds were shown to have potent antibacterial activity against microorganisms, and a molecular docking analysis revealed a favorable binding contact with the target bacterial DNA gyrase (PDB ID: 1KZN) of S. aureus. Furthermore, in silico ADMET calculations were performed for all synthesized compounds that showed promise when compared to conventional ciprofloxacin.
AIP Conference Proceedings, 2017
Green synthesis of chalcones derivatives as intermediate of flavones and their antibacterial acti... more Green synthesis of chalcones derivatives as intermediate of flavones and their antibacterial activities
Acta crystallographica. Section E, Crystallographic communications, 2017
The conformation of the title compound, C34H26F2O6, is cone-shaped, partially determined by intra... more The conformation of the title compound, C34H26F2O6, is cone-shaped, partially determined by intra-molecular C-H⋯O short contacts. The benzene rings at the top of the cone are inclined to one another by 73.10 (7)°, while the benzene rings at the bottom of the cone are inclined to one another by 35.49 (8)°. In the crystal, mol-ecules are linked by C-H⋯O and C-H⋯F hydrogen bonds, forming a three-dimensional supra-molecular structure. There are also C-H⋯π contacts present within the framework structure.
AIP Conference Proceedings, 2017
In the present study; 5-(4-chlorophenyl azo)-2-hydroxy acetophenone (1) was prepared by diazotiza... more In the present study; 5-(4-chlorophenyl azo)-2-hydroxy acetophenone (1) was prepared by diazotization of 4-chloro aniline and its coupling reaction with 2-hydroxy acetophenone, then reacted with different azo benzyloxy benzaldehydes(3a-i) to give new synthesized 2-hydroxy chalcones(4a-i). The later compounds were subjected to oxidative cyclization by catalytic amount of I 2 in DMSO affording the target molecules new flavones bearing two azo-linkages (5a-i). The structures of the newly synthesized compounds were identified on the bases of their FT-IR, 1 H-NMR, 13 C-NMR and DEPT-135 spectra. The synthesized Flavone derivatives were evaluated against two types of bacteria gram positive (Staphylococcus aurous) and gram negative (Pseudomonas aeruginosa). The results showed that most of the synthesized flavones are more sensitive against (G-ve) bacteria than (G +ve) bacteria.