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Digestive and Liver Disease, 2008

An intravenous injection of heparin releases diamine oxidase (DAO) from villous tip enterocytes. ... more An intravenous injection of heparin releases diamine oxidase (DAO) from villous tip enterocytes. In a previous study, we found that postheparin plasma DAO (PHD) values were significantly lower in patients with malabsorption syndrome and small bowel atrophy at jejunal biopsy than in normal subjects. In this study we performed the PHD test in 14 coeliac patients before and after three and six months of gluten free diet to show whether the enterocytes maturing processes induced by the diet joined with enhanced PHD values and to assess the clinical usefulness of this test. In all subjects jejunal biopsy carried out after six months showed a partial but consistent histological recovery. The clinical status, xylosuria and daily faecal fat excretion improved progressively and there was a significant increase (p < 0O001) in mean PHD activity that reached the normal range after three months. After six months a further slight increase of the mean PHD value was recorded. These data indicate that PHD values rise together with the improved intestinal absorptive functions of coeliac patients on gluten free diet and that this test is a useful tool in monitoring recovery of the small bowel mucosa.

AIM: To study the prevalence of functional dyspepsia (FD)(Rome III criteria) across eating disord... more AIM: To study the prevalence of functional dyspepsia (FD)(Rome III criteria) across eating disorders (ED), obese patients, constitutional thinner and healthy volunteers. METHODS: Twenty patients affected by anorexia nervosa, 6 affected by bulimia nervosa, 10 affected by ED not otherwise specified according to diagnostic and statistical manual of mental disorders, 4th edition, nine constitutional thinner subjects and, thirty-two obese patients were recruited from an outpatients clinic devoted to eating behavior disorders.

Summary The trefoil factor family (TFF) encompasses small peptides of which intestinal trefoil fa... more Summary The trefoil factor family (TFF) encompasses small peptides of which intestinal trefoil factor (ITF) is expressed specifically in goblet cells of the small and large intestine. Previous studies have shown that ITF plays an important role in mucosal protection and repair. Coeliac disease represents a model of immune-mediated small intestinal inflammation and damage, with recovery on gluten-free diet.

Materials and Methods: We conducted a ran-domized, double-blind, multicentre study in 186 patient... more Materials and Methods: We conducted a ran-domized, double-blind, multicentre study in 186 patients aged 18-65 years with IBS diagnosed according to Rome II criteria. Following a 2-week washout period, patients received octatropine plus diazepam 40 mg/2.5 mg twice daily or placebo for 6 weeks.

Abstract Transglutaminase (TG) activity is increased in the mucosa of patients with coeliac disea... more Abstract Transglutaminase (TG) activity is increased in the mucosa of patients with coeliac disease. Among 18 patients with untreated coeliac disease we have found a significant decrease (p less than 0.001) in serum levels of TG activity (0.72 (0.23) mU/ml). There was no significant differences between 16 treated coeliacs (1.24 (0.28) mU/ml) and 30 normal controls (1.63 (0.42) mU/ml).

Purpose The aim of this study is to test in a double-blinded, randomised placebo-controlled study... more Purpose The aim of this study is to test in a double-blinded, randomised placebo-controlled study the effects of a commercially available multi-strain symbiotic mixture on symptoms, colonic transit and quality of life in irritable bowel syndrome (IBS) patients who meet Rome III criteria. Background There is only one other double-blinded RCT on a single-strain symbiotic mixture in IBS. Methods This is a double-blinded, randomised placebo-controlled study of a symbiotic mixture (Probinul, 5 g bid) over 4 weeks after 2 weeks of run-in.

Abstract.–Although small bowel nonen-docrine neoplasms are rare, their incidence has increased dr... more Abstract.–Although small bowel nonen-docrine neoplasms are rare, their incidence has increased dramatically over the past 30 years. Small bowel malignacies can be classified depending upon their cellular origin into four principal histotypes: carcinoid tumors, adenocarcinomas, lymphomas and mesenchymal tumors.

BACKGROUND.: The development of cranial proportions is the result of genetic, embriogenetic and e... more BACKGROUND.: The development of cranial proportions is the result of genetic, embriogenetic and environmental factors. Coeliac disease is a genetically inherited disease that is frequently diagnosed in adulthood in individuals, in whom the disease runs unidentified for years and can affect child growth from the moment of dietary gluten introduction up to the moment of gluten withdrawal following diagnosis. Data on the effects of gluten on craniofacial development in coeliac children are not available.

Abstract The directional cell response to chemical gradients, referred to as chemotaxis, plays an... more Abstract The directional cell response to chemical gradients, referred to as chemotaxis, plays an important role in physiological and pathological processes including development, immune response and tumor cell invasion. Despite such implications, chemotaxis remains a challenging process to study under physiologically-relevant conditions in-vitro, mainly due to difficulties in generating a well characterized and sustained gradient in substrata mimicking the in-vivo environment while allowing dynamic cell imaging.

Abstract. – Background: Irritable bowel syndrome (IBS) is a very common functional gastrointestin... more Abstract. – Background: Irritable bowel syndrome (IBS) is a very common functional gastrointestinal (GI). Diagnosis of IBS is based on the fulfilment of the Rome III criteria. Common GI symptoms are lower abdominal pain, bloating and disturbed defecation, such as urgent diarrhoea and/or episodes of chronic constipation. Many agents have been employed in the management of IBS, although only few have been demonstrated to show a relevant efficacy.

Abstract Arthritis has often been alluded to as an extra-intestinal clinical manifestation of coe... more Abstract Arthritis has often been alluded to as an extra-intestinal clinical manifestation of coeliac disease, but definitive data regarding its prevalence are still lacking. We therefore evaluated the overall prevalence of articular involvement in 200 consecutive adult coeliac patients attending routine gastroenterology follow-up and in 40 controls, and determined whether the prevalence and pattern of articular involvement varied according to the dietary status.

From the Department of Medicine,“Dr C. Bonorino Udaondo” Gastroenterology Hospital, Buenos Aires,... more From the Department of Medicine,“Dr C. Bonorino Udaondo” Gastroenterology Hospital, Buenos Aires, Argentina. The authors declare that they have nothing to disclose. Reprints: Julio C. Bai, MD, Department of Medicine,“Dr C. Bonorino Udaondo” Gastroenterology Hospital, Caseros 2061, Buenos Aires 1264, Argentina (e-mail: jbai@ intramed. net). Copyright r 2013 by Lippincott Williams & Wilkins

BACKGROUND Villus atrophy is the most distinctive sign of untreated coeliac disease (CD) and epit... more BACKGROUND Villus atrophy is the most distinctive sign of untreated coeliac disease (CD) and epithelial apoptosis is considered to be involved in this stage of the coeliac lesion. The extent of villus atrophy is, however, not homogeneous and patients with patchy or mild lesions have been described. AIMS To address:(a) the degree of “patchiness” in untreated CD patients; and (b) to clarify if apoptosis, and eventually which trigger drives it, causes epithelial damage.

Abstract An intravenous injection of heparin releases diamine oxidase (DAO) from villous tip ente... more Abstract An intravenous injection of heparin releases diamine oxidase (DAO) from villous tip enterocytes. In a previous study, we found that postheparin plasma DAO (PHD) values were significantly lower in patients with malabsorption syndrome and small bowel atrophy at jejunal biopsy than in normal subjects.

Journal of Clinical Investigation, Jan 1, 1993

Digestive and Liver Disease, 2008

An intravenous injection of heparin releases diamine oxidase (DAO) from villous tip enterocytes. ... more An intravenous injection of heparin releases diamine oxidase (DAO) from villous tip enterocytes. In a previous study, we found that postheparin plasma DAO (PHD) values were significantly lower in patients with malabsorption syndrome and small bowel atrophy at jejunal biopsy than in normal subjects. In this study we performed the PHD test in 14 coeliac patients before and after three and six months of gluten free diet to show whether the enterocytes maturing processes induced by the diet joined with enhanced PHD values and to assess the clinical usefulness of this test. In all subjects jejunal biopsy carried out after six months showed a partial but consistent histological recovery. The clinical status, xylosuria and daily faecal fat excretion improved progressively and there was a significant increase (p < 0O001) in mean PHD activity that reached the normal range after three months. After six months a further slight increase of the mean PHD value was recorded. These data indicate that PHD values rise together with the improved intestinal absorptive functions of coeliac patients on gluten free diet and that this test is a useful tool in monitoring recovery of the small bowel mucosa.

AIM: To study the prevalence of functional dyspepsia (FD)(Rome III criteria) across eating disord... more AIM: To study the prevalence of functional dyspepsia (FD)(Rome III criteria) across eating disorders (ED), obese patients, constitutional thinner and healthy volunteers. METHODS: Twenty patients affected by anorexia nervosa, 6 affected by bulimia nervosa, 10 affected by ED not otherwise specified according to diagnostic and statistical manual of mental disorders, 4th edition, nine constitutional thinner subjects and, thirty-two obese patients were recruited from an outpatients clinic devoted to eating behavior disorders.

Summary The trefoil factor family (TFF) encompasses small peptides of which intestinal trefoil fa... more Summary The trefoil factor family (TFF) encompasses small peptides of which intestinal trefoil factor (ITF) is expressed specifically in goblet cells of the small and large intestine. Previous studies have shown that ITF plays an important role in mucosal protection and repair. Coeliac disease represents a model of immune-mediated small intestinal inflammation and damage, with recovery on gluten-free diet.

Materials and Methods: We conducted a ran-domized, double-blind, multicentre study in 186 patient... more Materials and Methods: We conducted a ran-domized, double-blind, multicentre study in 186 patients aged 18-65 years with IBS diagnosed according to Rome II criteria. Following a 2-week washout period, patients received octatropine plus diazepam 40 mg/2.5 mg twice daily or placebo for 6 weeks.

Abstract Transglutaminase (TG) activity is increased in the mucosa of patients with coeliac disea... more Abstract Transglutaminase (TG) activity is increased in the mucosa of patients with coeliac disease. Among 18 patients with untreated coeliac disease we have found a significant decrease (p less than 0.001) in serum levels of TG activity (0.72 (0.23) mU/ml). There was no significant differences between 16 treated coeliacs (1.24 (0.28) mU/ml) and 30 normal controls (1.63 (0.42) mU/ml).

Purpose The aim of this study is to test in a double-blinded, randomised placebo-controlled study... more Purpose The aim of this study is to test in a double-blinded, randomised placebo-controlled study the effects of a commercially available multi-strain symbiotic mixture on symptoms, colonic transit and quality of life in irritable bowel syndrome (IBS) patients who meet Rome III criteria. Background There is only one other double-blinded RCT on a single-strain symbiotic mixture in IBS. Methods This is a double-blinded, randomised placebo-controlled study of a symbiotic mixture (Probinul, 5 g bid) over 4 weeks after 2 weeks of run-in.

Abstract.–Although small bowel nonen-docrine neoplasms are rare, their incidence has increased dr... more Abstract.–Although small bowel nonen-docrine neoplasms are rare, their incidence has increased dramatically over the past 30 years. Small bowel malignacies can be classified depending upon their cellular origin into four principal histotypes: carcinoid tumors, adenocarcinomas, lymphomas and mesenchymal tumors.

BACKGROUND.: The development of cranial proportions is the result of genetic, embriogenetic and e... more BACKGROUND.: The development of cranial proportions is the result of genetic, embriogenetic and environmental factors. Coeliac disease is a genetically inherited disease that is frequently diagnosed in adulthood in individuals, in whom the disease runs unidentified for years and can affect child growth from the moment of dietary gluten introduction up to the moment of gluten withdrawal following diagnosis. Data on the effects of gluten on craniofacial development in coeliac children are not available.

Abstract The directional cell response to chemical gradients, referred to as chemotaxis, plays an... more Abstract The directional cell response to chemical gradients, referred to as chemotaxis, plays an important role in physiological and pathological processes including development, immune response and tumor cell invasion. Despite such implications, chemotaxis remains a challenging process to study under physiologically-relevant conditions in-vitro, mainly due to difficulties in generating a well characterized and sustained gradient in substrata mimicking the in-vivo environment while allowing dynamic cell imaging.

Abstract. – Background: Irritable bowel syndrome (IBS) is a very common functional gastrointestin... more Abstract. – Background: Irritable bowel syndrome (IBS) is a very common functional gastrointestinal (GI). Diagnosis of IBS is based on the fulfilment of the Rome III criteria. Common GI symptoms are lower abdominal pain, bloating and disturbed defecation, such as urgent diarrhoea and/or episodes of chronic constipation. Many agents have been employed in the management of IBS, although only few have been demonstrated to show a relevant efficacy.

Abstract Arthritis has often been alluded to as an extra-intestinal clinical manifestation of coe... more Abstract Arthritis has often been alluded to as an extra-intestinal clinical manifestation of coeliac disease, but definitive data regarding its prevalence are still lacking. We therefore evaluated the overall prevalence of articular involvement in 200 consecutive adult coeliac patients attending routine gastroenterology follow-up and in 40 controls, and determined whether the prevalence and pattern of articular involvement varied according to the dietary status.

From the Department of Medicine,“Dr C. Bonorino Udaondo” Gastroenterology Hospital, Buenos Aires,... more From the Department of Medicine,“Dr C. Bonorino Udaondo” Gastroenterology Hospital, Buenos Aires, Argentina. The authors declare that they have nothing to disclose. Reprints: Julio C. Bai, MD, Department of Medicine,“Dr C. Bonorino Udaondo” Gastroenterology Hospital, Caseros 2061, Buenos Aires 1264, Argentina (e-mail: jbai@ intramed. net). Copyright r 2013 by Lippincott Williams & Wilkins

BACKGROUND Villus atrophy is the most distinctive sign of untreated coeliac disease (CD) and epit... more BACKGROUND Villus atrophy is the most distinctive sign of untreated coeliac disease (CD) and epithelial apoptosis is considered to be involved in this stage of the coeliac lesion. The extent of villus atrophy is, however, not homogeneous and patients with patchy or mild lesions have been described. AIMS To address:(a) the degree of “patchiness” in untreated CD patients; and (b) to clarify if apoptosis, and eventually which trigger drives it, causes epithelial damage.

Abstract An intravenous injection of heparin releases diamine oxidase (DAO) from villous tip ente... more Abstract An intravenous injection of heparin releases diamine oxidase (DAO) from villous tip enterocytes. In a previous study, we found that postheparin plasma DAO (PHD) values were significantly lower in patients with malabsorption syndrome and small bowel atrophy at jejunal biopsy than in normal subjects.

Journal of Clinical Investigation, Jan 1, 1993