Ganesh Kumar | Sathyabama University (original) (raw)

Papers by Ganesh Kumar

Rasayan journal of Chemistry, 2020

Steel slag is generated during the steel production of around10-15% per tonne. Steel slag composi... more Steel slag is generated during the steel production of around10-15% per tonne. Steel slag composite has various metal oxides mainly composed of iron, aluminum, manganese and calcium along with silica. Dyes of textile industry effluent are one of the major threats to the environment. Methylene Blue (MB) a cationic dye originated from various dyeing processes of textile industries. In this research work, Induction Furnace (IF) steel slag is utilized in the removal of cationic textile dye Methylene Blue (MB). Steel slag materials were thermally activated at 600˚C for 4 hrs. UV-Vis spectroscopy is used to determine the removal properties of IF steel slag on MB dye. Adsorbent dosage, initial dye concentration and pH with various contact time were studied. Surface morphology and structural bonding of steel slag materials over dye molecule were studied using Scanning Electron Microscope (SEM) and Fourier Transform Infrared (FTIR) analysis respectively. The removal mechanism of textile dye (MB) using industrial by-product slag composite has been explored.

Nanotechnology has prospects of opening new avenues to fight and prevent diseases using atomic-sc... more Nanotechnology has prospects of opening new avenues to fight and prevent diseases using atomic-scale tailoring of materials. As the nano revolution emerges, it is imperative to develop "nano-naturo" links between nanotechnology and green domains of the nature. The present investigation describes the mangrove Rhizophora lamarckii's property of synthesizing magnesium oxide nanoparticles. The newly synthesized magnesium oxide nanoparticle morphology is nanohexagonal and spherical. The particles range in dimensions between 20 and 50 nm and are crystalline in nature. The functional groups of the mangrove, amine, and alkane are found to act as reductants and stabilizers. The newly synthesized MgO nanoparticles are found to have potent antibacterial activity.

Rasayan Journal of Chemistry, 2020

Rasayan Journal of Chemistry, 2019

In the present investigation, metakaolin is used to replace a portion of the cement and induction... more In the present investigation, metakaolin is used to replace a portion of the cement and induction furnace steel slag as partial replacement of fine aggregate in concrete. Metakaolin is a dehydroxylated aluminium silicate pozzolanic material obtained from kaolinite clay mineral. Induction Furnace steel slag is obtained as an industrial by-product during steel production. Hexagonal shaped paver block specimens of side 120 mm and height 80 mm are casted. Compressive strength, flexural Strength, split tensile strength, abrasion, water absorption, acid and alkali attack tests were performed. The results show that optimum level replacement of metakaolin (cement) and IF steel slag (fine aggregate) in concrete is 10% and 20% respectively.

Colloids and Surfaces B: Biointerfaces, 2011

Bio-directed synthesis of metal nanoparticles is gaining importance due to their biocompatibility... more Bio-directed synthesis of metal nanoparticles is gaining importance due to their biocompatibility, low toxicity and eco-friendly nature. We used culture supernatant of Pseudomonas aeruginosa strain BS-161R for the simple and cost effective green synthesis of silver nanoparticles. The reduction of silver ions occurred when silver nitrate solution was treated with the Pseudomonas aeruginosa culture supernatant at room temperature. The nanoparticles

Journal of chemical and pharmaceutical research, 2015

In the present investigation silver nanoparticles of spherical shape was synthesized biologically... more In the present investigation silver nanoparticles of spherical shape was synthesized biologically by rapid biological drip method using marine brown macro algae, Sargassum wightii (S. Wightii). Seaweed extract act as a reducing agent for silver nitrate. Silver nanoparticles have been characterized by UV-Visible spectrophotometer, Fourier-Transform Infrared spectroscopy (FTIR), X-ray diffractometer (XRD) and High Resolution Transmission Electron Microscope (HR-TEM). Antibacterial activity of these nanoparticles was carried out by antibiotic disc diffusion method against pathogenic microorganisms such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. Seaweed S. wightii mediated silver nanoparticles were found to be effective against these pathogens than silver nitrate.

V. Karthick, C. Akhila, V. Ganesh Kumar, D. Subashini, T. Stalin Dhas, K. Govindaraju, & K. Vasan... more V. Karthick, C. Akhila, V. Ganesh Kumar, D. Subashini, T. Stalin Dhas, K. Govindaraju, & K. Vasanth Nanoscience Division, Centre for Ocean Research, Sathyabama Institute of Science and Technology, Chennai, India Department of Biotechnology, Sathyabama Institute of Science and Technology, Chennai, India Interdisciplinary School of Indian System of Medicine, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India [E-mail: ganeshkumar@sathyabama.ac.in]

SN Applied Sciences, 2021

Metals and metal oxide-based nanocomposites play a significant role over the control of microbes.... more Metals and metal oxide-based nanocomposites play a significant role over the control of microbes. In this study, antibacterial activity of iron oxide (Fe2O3) nanocomposites based on induction furnace (IF) steel slag has been carried out. IF steel slag is an industrial by-product generated from secondary steel manufacturing process and has various metal oxides which includes Al2O3 (7.89%), MnO (5.06), CaO (1.49%) and specifically Fe2O3 (14.30%) in higher content along with metalloid SiO2 (66.42). Antibacterial activity of iron oxide nanocomposites has been revealed on bacterial species such as Micrococcus luteus, Bacillus subtilis and Staphylococcus aureus. Micrococcus luteus has undergone maximum zone of inhibition (ZOI) of 12 mm for 10 mg/mL concentration of steel slag iron oxide nanocomposite. Growth inhibitory kinetics of bacterial species has been studied using ELISA microplate reader at 660 nm by varying the concentration of steel slag iron oxide nanocomposites. The results ill...

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2013

In the present investigation, functionalization of gold nanoparticles synthesized using propanoic... more In the present investigation, functionalization of gold nanoparticles synthesized using propanoic acid 2-(3-acetoxy-4,4,14-trimethylandrost-8-en-17-yl) (PAT) an active biocomponent isolated from Cassia auriculata is studied in detail. On reaction of PAT with aqueous HAuCl4, rapid formation of stable gold nanoparticles was achieved. Formation of gold nanoparticles was confirmed by UV-vis spectroscopy, XRD, GC-MS,FTIR, TEM and SEM with EDAX. Gold nanoparticles mostly were monodisperse, spherical in shape and ranged in size 12-41 nm. Gold nanoparticles synthesised using PAT was administered to alloxan (150 mg/kg body weight) induced diabetic male albino rats at different doses (0.25, 0.5, 0.75 and 1.0mg/kg body weight) for 28 days. Plasma glucose level, cholesterol and triglyceride were significantly (p<0.001) reduced in experimental animals treated with gold nanoparticles at dosage of 0.5mg/kg body weight and plasma insulin increased significantly. The newly genre green gold nanopa...

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2012

h i g h l i g h t s " Biosynthesis of gold nanoparticles. " Pharmaceutical potential. " Single st... more h i g h l i g h t s " Biosynthesis of gold nanoparticles. " Pharmaceutical potential. " Single step synthesis.

Journal of …, 2009

Synthesis and stabilization of water dispersed silver nanoparticles was achieved by a simple one ... more Synthesis and stabilization of water dispersed silver nanoparticles was achieved by a simple one step procedure using N-methyl-N'-(5-indol-yl-pentyl)-4,4'-bipyridinium dibromide as reducing and stabilizing agent. The viologen pendant stabilized silver nanoparticles were characterized using UV-vis spectroscopy, Transmission Electron Microscope (TEM) and Atomic Force Microscopy (AFM). Further, viologen pendant stabilized silver nanoparticles were studied for antibacterial activity against Staphylococcus aureus, Escherichia coli, Bacillus cereus and Klebsiella nemoniae.

The process of development of reliable and eco-friendly metallic nanoparticles is an important st... more The process of development of reliable and eco-friendly metallic nanoparticles is an important step in the field of nanotechnology. To achieve this use of natural sources like biological systems becomes essential. In the present, work we have investigated extracellular biosynthesis of gold nanoparticles using Sargassum wightii and have achieved rapid formation of gold nanoparticles in a short duration. The UV-vis spectrum of the aqueous medium containing gold ion showed peak at 527 nm corresponding to the plasmon absorbance of gold nanoparicles. Transmission electron microcopy (TEM) showed formation of well-dispersed gold nanoparticles in the range of 8-12 nm. X-ray diffraction (XRD) spectrum of the gold nanoparticles exhibited Bragg reflections corresponding to gold nanoparticles.

A simple biological method for the synthesis of gold nanoparticles (AuNPs) using Cassia auriculat... more A simple biological method for the synthesis of gold nanoparticles (AuNPs) using Cassia auriculata aqueous leaf extract has been carried out in the present study. The reduction of auric chloride led to the formation of AuNPs within 10 min at room temperature (28 • C), suggesting a higher reaction rate than chemical methods involved in the synthesis. The size, shape and elemental analysis were carried out using X-ray diffraction, TEM, SEM-EDAX, FT-IR and visible absorption spectroscopy. Stable, triangular and spherical crystalline AuNPs with well-defined dimensions of average size of 15-25 nm were synthesized using C. auriculata. Effect of pH was also studied to check the stability of AuNPs. The main aim of the investigation is to synthesize AuNPs using antidiabetic potent medicinal plant. The stabilizing and reducing molecules of nanoparticles may promote anti-hyperglycemic if tested further.

Materials with enhanced physical and biological properties have been used for biomedical applicat... more Materials with enhanced physical and biological properties have been used for biomedical applications and can be developed by functionalizing them using various components. Hydroxyapatite (HAP), among other available synthetic material, serves as one of the best tools in orthopaedics and ceramic coatings. The porous structure of HAP helps in bone cell regeneration, chemical integration of bone and also favours the interaction between bone and tissues. Herein, we have demonstrated a simple procedure for the synthesis of HAP using low molecular weight heparin (LMWH), a structural analogue of bone heparan sulphate proteoglycan. The presence of small sized HAP plates with well-defined structures was revealed using electron microscopic analysis. The phase purity of the synthesized HAP was evaluated using X-ray diffraction pattern obtained before and after immersion in simulated body fluid (SBF).

In the present investigation, the cardioprotective nature of proanthocyanidin (PAC)-synthesized g... more In the present investigation, the cardioprotective nature of proanthocyanidin (PAC)-synthesized gold nanoparticles (AuNPs) is addressed in detail. There was a rapid reduction of gold metal ions by PAC and the new-genre AuNPs exhibited remarkable in vitro stability both in biological and chemical solutions. Transmission electron microscopy (TEM) indicated that the newly formed nanoparticles ranged in size from 17 to 29 nm (∼24 nm). MTT assay carried out with peripheral blood mononuclear cells demonstrated the non-toxic nature of AuNPs. PAC-synthesized AuNPs showed cardioprotective action in isoproterenol-induced myocardial injury at a lowest dosage (9 mg kg −1 ). Cardiac marker enzymes and antioxidant parameters in serum and heart tissue were also measured.

Please cite this article in press as: V. Karthick, et al., Effect of biologically synthesized gol... more Please cite this article in press as: V. Karthick, et al., Effect of biologically synthesized gold nanoparticles on alloxan-induced diabetic rats-An in vivo approach, Colloids Surf. B: Biointerfaces (2014), http://dx.a b s t r a c t Development of novel antidiabetic agents using various organic compounds and biomolecules has been in practice for a long time. Recently, nanomaterials are also being used in antidiabetic studies for their unique properties such as small size, biocompatibility and ability to penetrate cell membrane for carrying drugs. Herein, in vivo antidiabetic activity of gold nanoparticles (AuNPs) synthesized using the antidiabetic potent plant Gymnema sylvestre R. Br on wistar albino rats has been evaluated. The formation of AuNPs and their morphology were confirmed using spectroscopic and microscopic analyses, respectively. The treatment of AuNPs has shown significant reduction in blood glucose level on diabetic rats. AuNPs were also tested for its anti-inflammatory effect by estimating the serum levels of tumor necrosis factor-alpha (TNF-␣), interleukin-6 (IL-6) and high-sensitive C-reactive protein (CRP).

Interaction of single-cell protein of Spirulina platensis with aqueous AgNO3 and HAuCl4 was inves... more Interaction of single-cell protein of Spirulina platensis with aqueous AgNO3 and HAuCl4 was investigated for the synthesis of Ag, Au and Au core—Ag shell nanoparticles. Biological reduction and extracellular synthesis of nanoparticles were achieved in 120 h at 37 °C at pH 5.6. The nanometallic dispersions were characterized by surface plasmon absorbance measuring at 424 and 530 nm for Ag and Au nanoparticles, respectively. For bimetallic nanoparticles, absorption peak was observed at 509, 486 and 464 nm at 75:25, 50:50 and 25:75 (Au:Ag) mol concentrations, respectively. High-resolution transmission electron microscopy showed formation of nanoparticles in the range of 7–16 (silver), 6–10 (gold) and 17–25 nm (bimetallic 50:50 ratio). XRD analysis of the silver and gold nanoparticles confirmed the formation of metallic silver and gold. Fourier transform infrared spectroscopic measurements revealed the fact that the protein is the possible biomolecule responsible for the reduction and capping of the biosynthesized nanoparticles.

Extracellular synthesis of silver nanoparticles by a brown seaweed, Sargassum wightii is reported... more Extracellular synthesis of silver nanoparticles by a brown seaweed, Sargassum wightii is reported in this study. The silver nanoparticles synthesized by this method were characterized by means of UV-Vis spectroscopy, FT-IR, XRD and HR-TEM. Antibacterial studies were carried out using the bacteriae isolated from the infected silkworm. The recorded antibacterial effect of silver nanoparticles was found more potent when compared to the chemically synthesized silver nanoparticles and it is expected to be biocompatible.