MD. SHOFIUL AZAM | University of Chinese Academy of Sciences (original) (raw)

Papers by MD. SHOFIUL AZAM

Food Science and Nutrition, May 22, 2023

Viruses produce a variety of illnesses, which may also cause acute respiratory syndrome. All vira... more Viruses produce a variety of illnesses, which may also cause acute respiratory syndrome. All viral infections, including COVID‐19, are associated with the strength of the immune system. Till now, traditional medicine or vaccines for most viral diseases have not been effective. Antiviral and immune‐boosting diets may provide defense against viral diseases by lowering the risk of infection and assisting rapid recovery. The purpose of this review was to gather, analyze, and present data based on scientific evidence in order to provide an overview of the mechanistic insights of antiviral bioactive metabolites. We have covered a wide range of food with antiviral properties in this review, along with their potential mechanism of action against viral infections. Additionally, the opportunities and challenges of using antiviral food have been critically reviewed. Bioactive plant compounds, not only help in maintaining the body's normal physiological mechanism and good health but are also essential for improving the body's immunity and therefore can be effective against viral diseases. These agents fight viral diseases either by incorporating the body's defense mechanism or by enhancing the cell's immune system. Regular intake of antiviral foods may prevent future pandemic and consumption of these antiviral agents with traditional medicine may reduce the severity of viral diseases. Therefore, the synergistic effect of antiviral foods and medication needs to be investigated.

Food Science and Nutrition, Jun 6, 2017

Polyunsaturated fatty acids (PUFA) are considered as functional ingredients and beneficial to the... more Polyunsaturated fatty acids (PUFA) are considered as functional ingredients and beneficial to the human health. Finding a career food suitable for delivering them is still a challenge to food industry. Ice cream is a highly popular food item that could be used to deliver PUFA. The aims of the study were to develop functional dairy ice creams (Vanilla and Chocolate flavored) fortified with silver carp oil, a rich and cheapest source of PUFA and to investigate the physiochemical and sensory properties of developed fortified ice cream compared to control sample. Prior to addition to the ice cream mix, silver carp oil was microencapsulated by modified starch and maltodextrin to mask the fishy off flavor. The fat, solid non-fat, protein content, viscosity, specific gravity of the ice cream mixes and pH, acidity, microstructure, over run, melting properties of frozen ice cream were examined. The ice cream samples were also evaluated for sensory attributes of color and appearance, body and texture, flavor and taste, and over all acceptability. Study revealed addition of silver carp oil microcapsules did not significantly affect the physiochemical properties of ice cream except fat and SNF content (p<0.05). The fat content of ice creams were ranging from 11.41 to 11.83% wherein chocolate flavored fortified ice cream had the highest fat. Ice creams fortified with fish oil microcapsule also had significantly higher solid non-fat (SNF) content compared to their respective control sample. Sensory evaluation test presented that panelists could detect the presence of fish oil only in fortified vanilla flavored ice cream resulting in a lower acceptability (67.92%), however a decent acceptability (82.17%) was obtained by fortified chocolate flavored ice cream. Results indicated that development of ice cream fortified with microencapsulated silver carp oil could be an effective way to deliver PUFA and enhance nutritional and functional values of ice cream.

Pharmaceutical Research, Apr 1, 2022

PURPOSE This review aims to provide a precise perceptive of the insulin-degrading enzyme (IDE) an... more PURPOSE This review aims to provide a precise perceptive of the insulin-degrading enzyme (IDE) and its relationship to type 2 diabetes (T2D), Alzheimer's disease (AD), obesity, and cardiovascular diseases. The purpose of the current study was to provide clear idea of treating prevalent diseases such as T2D, and AD by molecular pharmacological therapeutics rather than conventional medicinal therapy. METHODS To achieve the aims, molecular docking was performed using several softwares such as LIGPLOT+, Python, and Protein-Ligand Interaction Profiler with corresponding tools. RESULTS The IDE is a large zinc-metalloprotease that breakdown numerous pathophysiologically important extracellular substrates, comprising amyloid β-protein (Aβ) and insulin. Recent studies demonstrated that dysregulation of IDE leads to develop AD and T2D. Specifically, IDE regulates circulating insulin in a variety of organs via a degradation-dependent clearance mechanism. IDE is unique because it was subjected to allosteric activation and mediated via an oligomer structure. CONCLUSION In this review, we summarised the factors that modulate insulin reformation by IDE and interaction of IDE and some recent reports on IDE inhibitors against AD and T2D. We also highlighted the latest signs of progress of the function of IDE and challenges in advancing IDE- targetted therapies against T2D and AD.

The Fusarium mycotoxins are one of the agro-economically important toxins that seriously and freq... more The Fusarium mycotoxins are one of the agro-economically important toxins that seriously and frequently contaminate cereal-derived food and feedstuffs. The currently biological enzymes are widely applied in practice with ubiquitous acceptance for the desirably specific degradation of target mycotoxin contamination. Simultaneously, biotransformation of target mycotoxins by application with the specific enzyme is a suitable and practically favorable prevention measure. Major Fusarium mycotoxins studied in this section are the following: trichothecene, zearalenone, and fumonisins groups. The possible bi- or trifunctional enzymes for degrading various target mycotoxins are also first mentioned as the trend. This section also discussed various resources of these degradation enzymes. In the future perspective, as predicted, this enzymatic control measure needs to target the actual co-occurring mycotoxins to strengthen its industrial and economic importance. From this control strategy, especially through the large-scale application, cereal-derived food and feedstuffs will be obviously protected and will minimize the food loss to ensure food security. Ultimately, food safety problems will be somewhat resolved worldwide.

Health protection/management is a point of view is one the imperative issues for all developing n... more Health protection/management is a point of view is one the imperative issues for all developing nations and holds a great importance for Bangladesh as well. This research study examines about basic wellbeing care in Bangladesh. For this study we have utilized research articles, daily newspaper and related bulletin to build a supportive literature review. Main analysis includes the qualitative study of the available literature. The study illustrates that Bangladesh faces so many challenges in health care framework to disperse the facilities to masses. Fundamental issues summarized include; health care Policy framework, Fraud & misconduct in Health care segment, Lack of association and participation of private sector (NGO), destitute individuals, Low health care information and deficiency of new modern framework and systems in Health Industry. The suggested long-term effective remedies include; First-rate administration & Governance, registrations and documentation of private segment with application of modern advancements of ICT and internet based surveillance and supervision of all sectors. Bangladesh has a few additional plus points since it manufactures economical and low priced medication. Here, government clinics and health care institutes provide nearly free expert advices, treatment and medication.

Food Research, Oct 23, 2022

The compound polysaccharide composed of chitosan and hydroxypropyl starch was aimed in this study... more The compound polysaccharide composed of chitosan and hydroxypropyl starch was aimed in this study to be used as a novel treatment to improve the quality of Tilapia fish surimi. Surimi gel properties, retention of oil, rate of water loss, colour changes, changes in protein content and gas composition were analysed. Compared with the control group, with the increase of hydroxypropyl starch content, the rate of water loss in all the groups (chitosan and hydroxypropyl starch) was improved, and 1.5% chitosan-treated samples showed significantly lower water losses. The protein content tended to increase at the beginning and then decrease. The whiteness index of surimi in both groups was significantly improved. The addition of 1.0% hydroxypropyl starch showed the highest oil retention in all treated groups (1.0% chitosan treated sample showed oil retention of 0.77 mL/g, while 1.5% chitosan treated samples showed maximum oil retention of 0.7 mL/g). Gas chromatography-mass spectroscopy (GC-MS) analysis detected two identical volatile organic compounds (VOCs) in both the control and compound polysaccharide groups. These results indicate that using complex polysaccharides can significantly improve the quality of fish surimi and, therefore, can be used as a practical basis for industries to improve freshwater fish surimi's gel properties.

Journal of Food Processing and Preservation

Journal of Food Measurement and Characterization

Journal of Agriculture and Food Research, 2021

Abstract Recently, the demand for natural antioxidants in food manufacturing has increased signif... more Abstract Recently, the demand for natural antioxidants in food manufacturing has increased significantly because of the possible toxicity of synthetic antioxidants. In this context, this research work was performed to evaluate the potentiality of seed (seed with kernel) and pulp (edible portion: pulp with peel) of Syzygium claviflorum to serve as natural antioxidants. The free radical scavenging capacity of S. claviflorum extracts was evaluated by 2,2′-azino-bis (3-ethylbenzothiazolin)-6-sulfonic acid (ABTS), and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays. In DPPH and ABTS free radical scavenging assays seed extract demonstrated significantly (p

Agronomy, 2021

Nontoxic polymers PVP and Na-alginate may provide a favorable environment for the survival of bac... more Nontoxic polymers PVP and Na-alginate may provide a favorable environment for the survival of bacteria. Therefore, PVP and Na-alginate were added to a growth medium to develop a liquid inoculant of Bradyrhizobium japonicum strain. The strain was identified by 16S rDNA sequencing. The addition of PVP (1.8%) and Na-alginate (0.2%) in the medium promoted a better survival (1.93 × 109 cells mL−1) of B. japonicum strain compared to the control (3.50 × 102 cells mL−1) after 6 months of storage. The combination of PVP and Na-alginate ensured 1.53 × 107 cells mL−1 up to 12 months of storage under ambient temperature (28 ± 2 °C), whereas PVP (1.8%) or Na-alginate (0.2%) alone produced similar cell counts only up to 8 months and 6 months, respectively. Consecutive field experiments proved the efficacy of the liquid inoculant on nodulation and yield of soybean. The combination of PVP and Na-alginate-based inoculation of B. japonicum strain significantly increased the nodule number per plant, n...

Toxins, 2019

Zearalenone (ZEA) is an estrogenic and ochratoxin A (OTA) is a hepatotoxic Fusarium mycotoxin com... more Zearalenone (ZEA) is an estrogenic and ochratoxin A (OTA) is a hepatotoxic Fusarium mycotoxin commonly seen in cereals and fruits products. No previous investigation has studied on a single platform for the multi degradation mycotoxin. The current study aimed to investigate the bifunctional activity of a novel fusion recombinant. We have generated a recombinant fusion enzyme (ZHDCP) by combining two single genes named zearalenone hydrolase (ZHD) and carboxypeptidase (CP) in frame deletion by crossover polymerase chain reaction (PCR). We identified enzymatic properties and cell cytotoxicity assay of ZHDCP enzyme. Our findings have demonstrated that ZEA was completely degraded to the non-toxic product in 2 h by ZHDCP enzyme at an optimum pH of 7 and a temperature of 35 °C. For the first time, it was found out that ZEA 60% was degraded by CP degrades in 48 h. Fusion ZHDCP and CP enzyme were able to degrade 100% OTA in 30 min at pH 7 and temperature 30 °C. ZEA- and OTA-induced cell deat...

Journal of Aquatic Food Product Technology, 2019

This study aimed to microencapsulate silver carp oil by spray drying with different combinations ... more This study aimed to microencapsulate silver carp oil by spray drying with different combinations of wall materials (gum Arabic, modified starch Hi-cap, maltodextrin, and inulin) and evaluate the effects of these combinations on the physiochemical and oxidative stability of the microcapsules. Feed emulsions were also investigated prior to spray drying. Modified starch-based microcapsules had higher encapsulation efficiency (91.22-92.78%) and yield (87.41-92.15%), excellent solubility (91.85-93.67%), good particle size (301.20-407.73 d.nm), color, and powder morphology. The presence of inulin reduced agglomeration in powders. All the powders exhibited good protection against lipid oxidation during 2 months of storage, whereas the modified starch and inulin combination provided the best stability.

Scientific Reports, 2016

Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic tr... more Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic transition between fasting and feeding, whereas much less is known about the mechanism of its own expression. Here we show that hepatic Angptl8 is rhythmically expressed, which involving the liver X receptor alpha (LXRα) and glucocorticoid receptor (GR) modulation during feeding and fasting periods, respectively. In addition, Angptl8 mRNA is very unstable, which contributes to the nature of its daily rhythmicity by rapidly responding to fasting/feeding transition. To explore its pathological function in dexamethasone (DEX)-induced fatty liver, we reversed its suppression by glucocorticoids through adenoviral delivery of Angptl8 gene in mouse liver. Surprisingly, hepatic overexpression of Angptl8 dramatically elevated plasma triglyceride (TG) and non-esterified fatty acid (NEFA) levels in DEX-treated mice, suggesting a metabolic interaction between Angptl8 and glucocorticoid signaling. More...

Advances in Bioscience and Bioengineering, 2015

The screening method for discovering new lipid synthesis inhibitors has not been well developed. ... more The screening method for discovering new lipid synthesis inhibitors has not been well developed. Lipid synthesis genes are responsible for the synthesis of fatty acids in normal and tumor cells. Mortierella alpina(M. alpina) fungus has been found to produce large amounts of fatty acids because it possesses a full complement of lipid synthesis genes. We therefore hypothesized that M. alpina could be a good screening tool to find new compounds that inhibit fatty acid synthesis. We developed a M. alpina liquid culture based method to analyze the inhibitory effects of lipid synthesis inhibitors. We applied a color indicator method to monitor the oil production using some well documented lipid inhibitors (C75, Cerulenin) to verify the system, and analyzing pictures using image analysis software. The experimental drug nocodazole inhibited the lipid production in M. alpina almost to the same extent as the control inhibitors. Compared with biomass and protein levels, there was a profound effect on fatty acid level. We report the development of a fast and effective method for screening lipid synthesis inhibitors which can be used against obesity and cancer. This method can further be used to screen additional lipid and fatty acid synthesis inhibitors from natural compound libraries.

EUROPEAN ACADEMIC RESEARCH , 2017

Reduction of childhood morbidity and mortality was the 4 th goal of Millennium development Goal a... more Reduction of childhood morbidity and mortality was the 4 th goal of Millennium development Goal and routine measles vaccination coverage was one of the indicators of progress for the reduction of childhood mortality and morbidity. So the consideration for achieving this goal, funds were increased by national and international agencies and worked with national government. Furthermore, they had tried to find out more influential factors which will have strong significances for taking measles vaccination as well as for covering 100% measles vaccination. From that sense, paternal educational level was one of the factors which can played an important role for up taking measles vaccination among 9 to 59 months of child.

EUROPEAN ACADEMIC RESEARCH , 2017

Objectives: The objective of this study was what motivation worked on worker for doing to the tob... more Objectives: The objective of this study was what motivation worked on worker for doing to the tobacco factory and how to influence to do this such type of works. Try to explore the motivational factors what respondents thought about those types of motivation. Methods: Qualitative method was used in this study. Rapport building was done with in-depth techniques. Data collection procedure was according to qualitative method. Written consent, recorder and field dairy were used during interview. In-depth interview technique was applied for conducting 25 in-depth interviews followed by one Bengali guideline. Data analysis was done by one researcher and one research assistant and report was written by researcher. Results: Socio economic, psychological and regional causes and belief were main factors which were influenced tremendously upon workers. Socioeconomic motivation like economic crisis, inspiration of friend's proposal, scarcity of other job, level of tobacco addiction, Cultivation and occupation and hereditary were influenced on tobacco workers to join in tobacco factory. Moreover, psychological factors like

American Journal of Social Sciences , 2018

Health protection/management is a point of view is one the imperative issues for all developing n... more Health protection/management is a point of view is one the imperative issues for all developing nations and holds a great importance for Bangladesh as well. This research study examines about basic wellbeing care in Bangladesh. For this study we have utilized research articles, daily newspaper and related bulletin to build a supportive literature review. Main analysis includes the qualitative study of the available literature. The study illustrates that Bangladesh faces so many challenges in health care framework to disperse the facilities to masses. Fundamental issues summarized include; health care Policy framework, Fraud & misconduct in Health care segment, Lack of association and participation of private sector (NGO), destitute individuals, Low health care information and deficiency of new modern framework and systems in Health Industry. The suggested long-term effective remedies include; First-rate administration & Governance, registrations and documentation of private segment with application of modern advancements of ICT and internet based surveillance and supervision of all sectors. Bangladesh has a few additional plus points since it manufactures economical and low priced medication. Here, government clinics and health care institutes provide nearly free expert advices, treatment and medication.

Scientific RepoRts , 2016

Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic tr... more Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic transition between fasting and feeding, whereas much less is known about the mechanism of its own expression. Here we show that hepatic Angptl8 is rhythmically expressed, which involving the liver X receptor alpha (LXRα) and glucocorticoid receptor (GR) modulation during feeding and fasting periods, respectively. In addition, Angptl8 mRNA is very unstable, which contributes to the nature of its daily rhythmicity by rapidly responding to fasting/feeding transition. To explore its pathological function in dexamethasone (DEX)-induced fatty liver, we reversed its suppression by glucocorticoids through adenoviral delivery of Angptl8 gene in mouse liver. Surprisingly, hepatic overexpression of Angptl8 dramatically elevated plasma triglyceride (TG) and non-esterified fatty acid (NEFA) levels in DEX-treated mice, suggesting a metabolic interaction between Angptl8 and glucocorticoid signaling. Moreover, intracellular hepatic Angptl8 is implicated in the regulation of lipid homeostasis by the experiments with ectopic expression of a nonsecreted Angptl8 mutant (Δ25-Angptl8). Altogether, our data demonstrate the molecular mechanism of the diurnal rhythm of Angptl8 expression regulated by glucocorticoid signaling and LXRα pathway, and provide new evidence to understand the role of Angptl8 in maintaining plasma TG homeostasis. Hypertriglyceridemia is one of major risk factors of nonalcoholic fatty liver (NAFL), and elevated serum triglyc-erides (TG) commonly associates with insulin resistance and represent a valuable clinical marker of the metabolic syndrome 1,2. Plasma TG concentrations are mainly determined by the balance between their production and clearance. The former involves the synthesis of very low density lipoprotein triglyceride (VLDL-TG) and chy-lomicron triglyceride (chylomicron-TG) in the liver and small intestine 3,4 , respectively, while the latter involves lipoprotein lipase (LPL)-mediated lipolysis of VLDL-TG 5. Angiopoietin-like proteins (Angptls) are a family of proteins structurally similar to the angiopoietins. Angptls have emerged as crucial regulators of circulating TG levels and thus have been expected as potential targets for metabolic syndrome therapy in recent years 6,7. For instance, Angptl3 and Angptl4 have been reported to inhibit LPL activity to impair TG clearance 8-10. Several studies with Angptl8-deficient and/or Angptl8-overexpressing mice have revealed that Angptl8, similar to Angptl3 and 4, plays an important role in modulating circulating TG clearance via the inhibition of LPL activity 11-13. Of note, overexpression of Angptl3 alone does not alter the levels of circulating TG, whereas co-expressing it with Angptl8 results in hypertriglyceridemia in mice 11. On the other hand, ectopic expression of Angptl8 in Angptl3-null mice has also little effect on plasma TG levels 11. These results indicate that Angptl3 and Angptl8 have to function together in vivo. Previous studies have shown that Angptl8 is dramatically suppressed by fasting and significantly induced by refeeding in mice 12,14,15. Although many efforts have been taken 12,15-17 , the regulatory mechanisms of Angptl8 gene expression remain inconclusive. Here we show that the liver X receptor alpha (LXRα) and glucocorticoid receptor

American Journal of Food Science and Nutrition Research , 2017

Polyunsaturated fatty acids (PUFA) are considered as functional ingredients and beneficial to the... more Polyunsaturated fatty acids (PUFA) are considered as functional ingredients and beneficial to the human health. Finding a career food suitable for delivering them is still a challenge to food industry. Ice cream is a highly popular food item that could be used to deliver PUFA. The aims of the study were to develop functional dairy ice creams (Vanilla and Chocolate flavored) fortified with silver carp oil, a rich and cheapest source of PUFA and to investigate the physiochemical and sensory properties of developed fortified ice cream compared to control sample. Prior to addition to the ice cream mix, silver carp oil was microencapsulated by modified starch and maltodextrin to mask the fishy off flavor. The fat, solid non-fat, protein content, viscosity, specific gravity of the ice cream mixes and pH, acidity, microstructure, over run, melting properties of frozen ice cream were examined. The ice cream samples were also evaluated for sensory attributes of color and appearance, body and texture, flavor and taste, and over all acceptability. Study revealed addition of silver carp oil microcapsules did not significantly affect the physiochemical properties of ice cream except fat and SNF content (p<0.05). The fat content of ice creams were ranging from 11.41 to 11.83% wherein chocolate flavored fortified ice cream had the highest fat. Ice creams fortified with fish oil microcapsule also had significantly higher solid non-fat (SNF) content compared to their respective control sample. Sensory evaluation test presented that panelists could detect the presence of fish oil only in fortified vanilla flavored ice cream resulting in a lower acceptability (67.92%), however a decent acceptability (82.17%) was obtained by fortified chocolate flavored ice cream. Results indicated that development of ice cream fortified with microencapsulated silver carp oil could be an effective way to deliver PUFA and enhance nutritional and functional values of ice cream.

Journal of Aquatic Food Product Technology, 2018

This study aimed to microencapsulate silver carp oil by spray drying with different combinations ... more This study aimed to microencapsulate silver carp oil by spray drying with
different combinations of wall materials (gum Arabic, modified starch Hi-cap,
maltodextrin, and inulin) and evaluate the effects of these combinations on
the physiochemical and oxidative stability of the microcapsules. Feed emul-
sions were also investigated prior to spray drying. Modified starch-based
microcapsules had higher encapsulation efficiency (91.22-92.78%) and yield
(87.41-92.15%), excellent solubility (91.85-93.67%), good particle size (301.20-
407.73 d.nm), color, and powder morphology. The presence of inulin reduced
agglomeration in powders. All the powders exhibited good protection
against lipid oxidation during 2 months of storage, whereas the modified
starch and inulin combination provided the best stability.

Food Science and Nutrition, May 22, 2023

Viruses produce a variety of illnesses, which may also cause acute respiratory syndrome. All vira... more Viruses produce a variety of illnesses, which may also cause acute respiratory syndrome. All viral infections, including COVID‐19, are associated with the strength of the immune system. Till now, traditional medicine or vaccines for most viral diseases have not been effective. Antiviral and immune‐boosting diets may provide defense against viral diseases by lowering the risk of infection and assisting rapid recovery. The purpose of this review was to gather, analyze, and present data based on scientific evidence in order to provide an overview of the mechanistic insights of antiviral bioactive metabolites. We have covered a wide range of food with antiviral properties in this review, along with their potential mechanism of action against viral infections. Additionally, the opportunities and challenges of using antiviral food have been critically reviewed. Bioactive plant compounds, not only help in maintaining the body's normal physiological mechanism and good health but are also essential for improving the body's immunity and therefore can be effective against viral diseases. These agents fight viral diseases either by incorporating the body's defense mechanism or by enhancing the cell's immune system. Regular intake of antiviral foods may prevent future pandemic and consumption of these antiviral agents with traditional medicine may reduce the severity of viral diseases. Therefore, the synergistic effect of antiviral foods and medication needs to be investigated.

Food Science and Nutrition, Jun 6, 2017

Polyunsaturated fatty acids (PUFA) are considered as functional ingredients and beneficial to the... more Polyunsaturated fatty acids (PUFA) are considered as functional ingredients and beneficial to the human health. Finding a career food suitable for delivering them is still a challenge to food industry. Ice cream is a highly popular food item that could be used to deliver PUFA. The aims of the study were to develop functional dairy ice creams (Vanilla and Chocolate flavored) fortified with silver carp oil, a rich and cheapest source of PUFA and to investigate the physiochemical and sensory properties of developed fortified ice cream compared to control sample. Prior to addition to the ice cream mix, silver carp oil was microencapsulated by modified starch and maltodextrin to mask the fishy off flavor. The fat, solid non-fat, protein content, viscosity, specific gravity of the ice cream mixes and pH, acidity, microstructure, over run, melting properties of frozen ice cream were examined. The ice cream samples were also evaluated for sensory attributes of color and appearance, body and texture, flavor and taste, and over all acceptability. Study revealed addition of silver carp oil microcapsules did not significantly affect the physiochemical properties of ice cream except fat and SNF content (p<0.05). The fat content of ice creams were ranging from 11.41 to 11.83% wherein chocolate flavored fortified ice cream had the highest fat. Ice creams fortified with fish oil microcapsule also had significantly higher solid non-fat (SNF) content compared to their respective control sample. Sensory evaluation test presented that panelists could detect the presence of fish oil only in fortified vanilla flavored ice cream resulting in a lower acceptability (67.92%), however a decent acceptability (82.17%) was obtained by fortified chocolate flavored ice cream. Results indicated that development of ice cream fortified with microencapsulated silver carp oil could be an effective way to deliver PUFA and enhance nutritional and functional values of ice cream.

Pharmaceutical Research, Apr 1, 2022

PURPOSE This review aims to provide a precise perceptive of the insulin-degrading enzyme (IDE) an... more PURPOSE This review aims to provide a precise perceptive of the insulin-degrading enzyme (IDE) and its relationship to type 2 diabetes (T2D), Alzheimer's disease (AD), obesity, and cardiovascular diseases. The purpose of the current study was to provide clear idea of treating prevalent diseases such as T2D, and AD by molecular pharmacological therapeutics rather than conventional medicinal therapy. METHODS To achieve the aims, molecular docking was performed using several softwares such as LIGPLOT+, Python, and Protein-Ligand Interaction Profiler with corresponding tools. RESULTS The IDE is a large zinc-metalloprotease that breakdown numerous pathophysiologically important extracellular substrates, comprising amyloid β-protein (Aβ) and insulin. Recent studies demonstrated that dysregulation of IDE leads to develop AD and T2D. Specifically, IDE regulates circulating insulin in a variety of organs via a degradation-dependent clearance mechanism. IDE is unique because it was subjected to allosteric activation and mediated via an oligomer structure. CONCLUSION In this review, we summarised the factors that modulate insulin reformation by IDE and interaction of IDE and some recent reports on IDE inhibitors against AD and T2D. We also highlighted the latest signs of progress of the function of IDE and challenges in advancing IDE- targetted therapies against T2D and AD.

The Fusarium mycotoxins are one of the agro-economically important toxins that seriously and freq... more The Fusarium mycotoxins are one of the agro-economically important toxins that seriously and frequently contaminate cereal-derived food and feedstuffs. The currently biological enzymes are widely applied in practice with ubiquitous acceptance for the desirably specific degradation of target mycotoxin contamination. Simultaneously, biotransformation of target mycotoxins by application with the specific enzyme is a suitable and practically favorable prevention measure. Major Fusarium mycotoxins studied in this section are the following: trichothecene, zearalenone, and fumonisins groups. The possible bi- or trifunctional enzymes for degrading various target mycotoxins are also first mentioned as the trend. This section also discussed various resources of these degradation enzymes. In the future perspective, as predicted, this enzymatic control measure needs to target the actual co-occurring mycotoxins to strengthen its industrial and economic importance. From this control strategy, especially through the large-scale application, cereal-derived food and feedstuffs will be obviously protected and will minimize the food loss to ensure food security. Ultimately, food safety problems will be somewhat resolved worldwide.

Health protection/management is a point of view is one the imperative issues for all developing n... more Health protection/management is a point of view is one the imperative issues for all developing nations and holds a great importance for Bangladesh as well. This research study examines about basic wellbeing care in Bangladesh. For this study we have utilized research articles, daily newspaper and related bulletin to build a supportive literature review. Main analysis includes the qualitative study of the available literature. The study illustrates that Bangladesh faces so many challenges in health care framework to disperse the facilities to masses. Fundamental issues summarized include; health care Policy framework, Fraud & misconduct in Health care segment, Lack of association and participation of private sector (NGO), destitute individuals, Low health care information and deficiency of new modern framework and systems in Health Industry. The suggested long-term effective remedies include; First-rate administration & Governance, registrations and documentation of private segment with application of modern advancements of ICT and internet based surveillance and supervision of all sectors. Bangladesh has a few additional plus points since it manufactures economical and low priced medication. Here, government clinics and health care institutes provide nearly free expert advices, treatment and medication.

Food Research, Oct 23, 2022

The compound polysaccharide composed of chitosan and hydroxypropyl starch was aimed in this study... more The compound polysaccharide composed of chitosan and hydroxypropyl starch was aimed in this study to be used as a novel treatment to improve the quality of Tilapia fish surimi. Surimi gel properties, retention of oil, rate of water loss, colour changes, changes in protein content and gas composition were analysed. Compared with the control group, with the increase of hydroxypropyl starch content, the rate of water loss in all the groups (chitosan and hydroxypropyl starch) was improved, and 1.5% chitosan-treated samples showed significantly lower water losses. The protein content tended to increase at the beginning and then decrease. The whiteness index of surimi in both groups was significantly improved. The addition of 1.0% hydroxypropyl starch showed the highest oil retention in all treated groups (1.0% chitosan treated sample showed oil retention of 0.77 mL/g, while 1.5% chitosan treated samples showed maximum oil retention of 0.7 mL/g). Gas chromatography-mass spectroscopy (GC-MS) analysis detected two identical volatile organic compounds (VOCs) in both the control and compound polysaccharide groups. These results indicate that using complex polysaccharides can significantly improve the quality of fish surimi and, therefore, can be used as a practical basis for industries to improve freshwater fish surimi's gel properties.

Journal of Food Processing and Preservation

Journal of Food Measurement and Characterization

Journal of Agriculture and Food Research, 2021

Abstract Recently, the demand for natural antioxidants in food manufacturing has increased signif... more Abstract Recently, the demand for natural antioxidants in food manufacturing has increased significantly because of the possible toxicity of synthetic antioxidants. In this context, this research work was performed to evaluate the potentiality of seed (seed with kernel) and pulp (edible portion: pulp with peel) of Syzygium claviflorum to serve as natural antioxidants. The free radical scavenging capacity of S. claviflorum extracts was evaluated by 2,2′-azino-bis (3-ethylbenzothiazolin)-6-sulfonic acid (ABTS), and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assays. In DPPH and ABTS free radical scavenging assays seed extract demonstrated significantly (p

Agronomy, 2021

Nontoxic polymers PVP and Na-alginate may provide a favorable environment for the survival of bac... more Nontoxic polymers PVP and Na-alginate may provide a favorable environment for the survival of bacteria. Therefore, PVP and Na-alginate were added to a growth medium to develop a liquid inoculant of Bradyrhizobium japonicum strain. The strain was identified by 16S rDNA sequencing. The addition of PVP (1.8%) and Na-alginate (0.2%) in the medium promoted a better survival (1.93 × 109 cells mL−1) of B. japonicum strain compared to the control (3.50 × 102 cells mL−1) after 6 months of storage. The combination of PVP and Na-alginate ensured 1.53 × 107 cells mL−1 up to 12 months of storage under ambient temperature (28 ± 2 °C), whereas PVP (1.8%) or Na-alginate (0.2%) alone produced similar cell counts only up to 8 months and 6 months, respectively. Consecutive field experiments proved the efficacy of the liquid inoculant on nodulation and yield of soybean. The combination of PVP and Na-alginate-based inoculation of B. japonicum strain significantly increased the nodule number per plant, n...

Toxins, 2019

Zearalenone (ZEA) is an estrogenic and ochratoxin A (OTA) is a hepatotoxic Fusarium mycotoxin com... more Zearalenone (ZEA) is an estrogenic and ochratoxin A (OTA) is a hepatotoxic Fusarium mycotoxin commonly seen in cereals and fruits products. No previous investigation has studied on a single platform for the multi degradation mycotoxin. The current study aimed to investigate the bifunctional activity of a novel fusion recombinant. We have generated a recombinant fusion enzyme (ZHDCP) by combining two single genes named zearalenone hydrolase (ZHD) and carboxypeptidase (CP) in frame deletion by crossover polymerase chain reaction (PCR). We identified enzymatic properties and cell cytotoxicity assay of ZHDCP enzyme. Our findings have demonstrated that ZEA was completely degraded to the non-toxic product in 2 h by ZHDCP enzyme at an optimum pH of 7 and a temperature of 35 °C. For the first time, it was found out that ZEA 60% was degraded by CP degrades in 48 h. Fusion ZHDCP and CP enzyme were able to degrade 100% OTA in 30 min at pH 7 and temperature 30 °C. ZEA- and OTA-induced cell deat...

Journal of Aquatic Food Product Technology, 2019

This study aimed to microencapsulate silver carp oil by spray drying with different combinations ... more This study aimed to microencapsulate silver carp oil by spray drying with different combinations of wall materials (gum Arabic, modified starch Hi-cap, maltodextrin, and inulin) and evaluate the effects of these combinations on the physiochemical and oxidative stability of the microcapsules. Feed emulsions were also investigated prior to spray drying. Modified starch-based microcapsules had higher encapsulation efficiency (91.22-92.78%) and yield (87.41-92.15%), excellent solubility (91.85-93.67%), good particle size (301.20-407.73 d.nm), color, and powder morphology. The presence of inulin reduced agglomeration in powders. All the powders exhibited good protection against lipid oxidation during 2 months of storage, whereas the modified starch and inulin combination provided the best stability.

Scientific Reports, 2016

Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic tr... more Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic transition between fasting and feeding, whereas much less is known about the mechanism of its own expression. Here we show that hepatic Angptl8 is rhythmically expressed, which involving the liver X receptor alpha (LXRα) and glucocorticoid receptor (GR) modulation during feeding and fasting periods, respectively. In addition, Angptl8 mRNA is very unstable, which contributes to the nature of its daily rhythmicity by rapidly responding to fasting/feeding transition. To explore its pathological function in dexamethasone (DEX)-induced fatty liver, we reversed its suppression by glucocorticoids through adenoviral delivery of Angptl8 gene in mouse liver. Surprisingly, hepatic overexpression of Angptl8 dramatically elevated plasma triglyceride (TG) and non-esterified fatty acid (NEFA) levels in DEX-treated mice, suggesting a metabolic interaction between Angptl8 and glucocorticoid signaling. More...

Advances in Bioscience and Bioengineering, 2015

The screening method for discovering new lipid synthesis inhibitors has not been well developed. ... more The screening method for discovering new lipid synthesis inhibitors has not been well developed. Lipid synthesis genes are responsible for the synthesis of fatty acids in normal and tumor cells. Mortierella alpina(M. alpina) fungus has been found to produce large amounts of fatty acids because it possesses a full complement of lipid synthesis genes. We therefore hypothesized that M. alpina could be a good screening tool to find new compounds that inhibit fatty acid synthesis. We developed a M. alpina liquid culture based method to analyze the inhibitory effects of lipid synthesis inhibitors. We applied a color indicator method to monitor the oil production using some well documented lipid inhibitors (C75, Cerulenin) to verify the system, and analyzing pictures using image analysis software. The experimental drug nocodazole inhibited the lipid production in M. alpina almost to the same extent as the control inhibitors. Compared with biomass and protein levels, there was a profound effect on fatty acid level. We report the development of a fast and effective method for screening lipid synthesis inhibitors which can be used against obesity and cancer. This method can further be used to screen additional lipid and fatty acid synthesis inhibitors from natural compound libraries.

EUROPEAN ACADEMIC RESEARCH , 2017

Reduction of childhood morbidity and mortality was the 4 th goal of Millennium development Goal a... more Reduction of childhood morbidity and mortality was the 4 th goal of Millennium development Goal and routine measles vaccination coverage was one of the indicators of progress for the reduction of childhood mortality and morbidity. So the consideration for achieving this goal, funds were increased by national and international agencies and worked with national government. Furthermore, they had tried to find out more influential factors which will have strong significances for taking measles vaccination as well as for covering 100% measles vaccination. From that sense, paternal educational level was one of the factors which can played an important role for up taking measles vaccination among 9 to 59 months of child.

EUROPEAN ACADEMIC RESEARCH , 2017

Objectives: The objective of this study was what motivation worked on worker for doing to the tob... more Objectives: The objective of this study was what motivation worked on worker for doing to the tobacco factory and how to influence to do this such type of works. Try to explore the motivational factors what respondents thought about those types of motivation. Methods: Qualitative method was used in this study. Rapport building was done with in-depth techniques. Data collection procedure was according to qualitative method. Written consent, recorder and field dairy were used during interview. In-depth interview technique was applied for conducting 25 in-depth interviews followed by one Bengali guideline. Data analysis was done by one researcher and one research assistant and report was written by researcher. Results: Socio economic, psychological and regional causes and belief were main factors which were influenced tremendously upon workers. Socioeconomic motivation like economic crisis, inspiration of friend's proposal, scarcity of other job, level of tobacco addiction, Cultivation and occupation and hereditary were influenced on tobacco workers to join in tobacco factory. Moreover, psychological factors like

American Journal of Social Sciences , 2018

Health protection/management is a point of view is one the imperative issues for all developing n... more Health protection/management is a point of view is one the imperative issues for all developing nations and holds a great importance for Bangladesh as well. This research study examines about basic wellbeing care in Bangladesh. For this study we have utilized research articles, daily newspaper and related bulletin to build a supportive literature review. Main analysis includes the qualitative study of the available literature. The study illustrates that Bangladesh faces so many challenges in health care framework to disperse the facilities to masses. Fundamental issues summarized include; health care Policy framework, Fraud & misconduct in Health care segment, Lack of association and participation of private sector (NGO), destitute individuals, Low health care information and deficiency of new modern framework and systems in Health Industry. The suggested long-term effective remedies include; First-rate administration & Governance, registrations and documentation of private segment with application of modern advancements of ICT and internet based surveillance and supervision of all sectors. Bangladesh has a few additional plus points since it manufactures economical and low priced medication. Here, government clinics and health care institutes provide nearly free expert advices, treatment and medication.

Scientific RepoRts , 2016

Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic tr... more Emerging evidence implies a key role of angiopoietin-like protein 8 (Angptl8) in the metabolic transition between fasting and feeding, whereas much less is known about the mechanism of its own expression. Here we show that hepatic Angptl8 is rhythmically expressed, which involving the liver X receptor alpha (LXRα) and glucocorticoid receptor (GR) modulation during feeding and fasting periods, respectively. In addition, Angptl8 mRNA is very unstable, which contributes to the nature of its daily rhythmicity by rapidly responding to fasting/feeding transition. To explore its pathological function in dexamethasone (DEX)-induced fatty liver, we reversed its suppression by glucocorticoids through adenoviral delivery of Angptl8 gene in mouse liver. Surprisingly, hepatic overexpression of Angptl8 dramatically elevated plasma triglyceride (TG) and non-esterified fatty acid (NEFA) levels in DEX-treated mice, suggesting a metabolic interaction between Angptl8 and glucocorticoid signaling. Moreover, intracellular hepatic Angptl8 is implicated in the regulation of lipid homeostasis by the experiments with ectopic expression of a nonsecreted Angptl8 mutant (Δ25-Angptl8). Altogether, our data demonstrate the molecular mechanism of the diurnal rhythm of Angptl8 expression regulated by glucocorticoid signaling and LXRα pathway, and provide new evidence to understand the role of Angptl8 in maintaining plasma TG homeostasis. Hypertriglyceridemia is one of major risk factors of nonalcoholic fatty liver (NAFL), and elevated serum triglyc-erides (TG) commonly associates with insulin resistance and represent a valuable clinical marker of the metabolic syndrome 1,2. Plasma TG concentrations are mainly determined by the balance between their production and clearance. The former involves the synthesis of very low density lipoprotein triglyceride (VLDL-TG) and chy-lomicron triglyceride (chylomicron-TG) in the liver and small intestine 3,4 , respectively, while the latter involves lipoprotein lipase (LPL)-mediated lipolysis of VLDL-TG 5. Angiopoietin-like proteins (Angptls) are a family of proteins structurally similar to the angiopoietins. Angptls have emerged as crucial regulators of circulating TG levels and thus have been expected as potential targets for metabolic syndrome therapy in recent years 6,7. For instance, Angptl3 and Angptl4 have been reported to inhibit LPL activity to impair TG clearance 8-10. Several studies with Angptl8-deficient and/or Angptl8-overexpressing mice have revealed that Angptl8, similar to Angptl3 and 4, plays an important role in modulating circulating TG clearance via the inhibition of LPL activity 11-13. Of note, overexpression of Angptl3 alone does not alter the levels of circulating TG, whereas co-expressing it with Angptl8 results in hypertriglyceridemia in mice 11. On the other hand, ectopic expression of Angptl8 in Angptl3-null mice has also little effect on plasma TG levels 11. These results indicate that Angptl3 and Angptl8 have to function together in vivo. Previous studies have shown that Angptl8 is dramatically suppressed by fasting and significantly induced by refeeding in mice 12,14,15. Although many efforts have been taken 12,15-17 , the regulatory mechanisms of Angptl8 gene expression remain inconclusive. Here we show that the liver X receptor alpha (LXRα) and glucocorticoid receptor

American Journal of Food Science and Nutrition Research , 2017

Polyunsaturated fatty acids (PUFA) are considered as functional ingredients and beneficial to the... more Polyunsaturated fatty acids (PUFA) are considered as functional ingredients and beneficial to the human health. Finding a career food suitable for delivering them is still a challenge to food industry. Ice cream is a highly popular food item that could be used to deliver PUFA. The aims of the study were to develop functional dairy ice creams (Vanilla and Chocolate flavored) fortified with silver carp oil, a rich and cheapest source of PUFA and to investigate the physiochemical and sensory properties of developed fortified ice cream compared to control sample. Prior to addition to the ice cream mix, silver carp oil was microencapsulated by modified starch and maltodextrin to mask the fishy off flavor. The fat, solid non-fat, protein content, viscosity, specific gravity of the ice cream mixes and pH, acidity, microstructure, over run, melting properties of frozen ice cream were examined. The ice cream samples were also evaluated for sensory attributes of color and appearance, body and texture, flavor and taste, and over all acceptability. Study revealed addition of silver carp oil microcapsules did not significantly affect the physiochemical properties of ice cream except fat and SNF content (p<0.05). The fat content of ice creams were ranging from 11.41 to 11.83% wherein chocolate flavored fortified ice cream had the highest fat. Ice creams fortified with fish oil microcapsule also had significantly higher solid non-fat (SNF) content compared to their respective control sample. Sensory evaluation test presented that panelists could detect the presence of fish oil only in fortified vanilla flavored ice cream resulting in a lower acceptability (67.92%), however a decent acceptability (82.17%) was obtained by fortified chocolate flavored ice cream. Results indicated that development of ice cream fortified with microencapsulated silver carp oil could be an effective way to deliver PUFA and enhance nutritional and functional values of ice cream.

Journal of Aquatic Food Product Technology, 2018

This study aimed to microencapsulate silver carp oil by spray drying with different combinations ... more This study aimed to microencapsulate silver carp oil by spray drying with
different combinations of wall materials (gum Arabic, modified starch Hi-cap,
maltodextrin, and inulin) and evaluate the effects of these combinations on
the physiochemical and oxidative stability of the microcapsules. Feed emul-
sions were also investigated prior to spray drying. Modified starch-based
microcapsules had higher encapsulation efficiency (91.22-92.78%) and yield
(87.41-92.15%), excellent solubility (91.85-93.67%), good particle size (301.20-
407.73 d.nm), color, and powder morphology. The presence of inulin reduced
agglomeration in powders. All the powders exhibited good protection
against lipid oxidation during 2 months of storage, whereas the modified
starch and inulin combination provided the best stability.