Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. (original) (raw)
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Cell | 2012
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non-myf-5 lineage. Here, we report the isolation of "beige" cells from murine white fat depots. Beige cells resemble white fat cells in having extremely low basal expression of UCP1, but, like classical brown fat, they respond to cyclic AMP stimulation with high UCP1 expression and respiration rates. Beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone irisin. Finally, we provide evidence that previously identified brown fat deposits in adult humans are composed of beige adipocytes. These data provide a foundation for studying this mammalian cell type with therapeutic potential. PAPERCLIP:
Pubmed ID: 22796012 RIS Download
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Associated grants
- Agency: NIDDK NIH HHS, United States
Id: DK90861 - Agency: NIDDK NIH HHS, United States
Id: RC4 DK090861 - Agency: NIDDK NIH HHS, United States
Id: K01 DK094824 - Agency: NIDDK NIH HHS, United States
Id: DK31405 - Agency: NIDDK NIH HHS, United States
Id: R37 DK031405 - Agency: NIDDK NIH HHS, United States
Id: R01 DK031405