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Resource Information

URL: http://www.broadinstitute.org/cancer/cga/absolute

Proper Citation: ABSOLUTE (RRID:SCR_005198)

Description: Software to estimate purity / ploidy, and from that compute absolute copy-number and mutation multiplicities. When DNA is extracted from an admixed population of cancer and normal cells, the information on absolute copy number per cancer cell is lost in the mixing. The purpose of ABSOLUTE is to re-extract these data from the mixed DNA population. This process begins by generation of segmented copy number data, which is input to the ABSOLUTE algorithm together with pre-computed models of recurrent cancer karyotypes and, optionally, allelic fraction values for somatic point mutations. The output of ABSOLUTE then provides re-extracted information on the absolute cellular copy number of local DNA segments and, for point mutations, the number of mutated alleles.

Abbreviations: ABSOLUTE

Resource Type: software resource

Defining Citation: PMID:22544022

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Related Condition: Cancer, Normal

Availability: Account required

Resource Name: ABSOLUTE

Resource ID: SCR_005198

Alternate IDs: OMICS_00217

Record Creation Time: 2022-01-29 12:02:28

Record Last Update: 2024-10-14 03:27:22

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