Structure and stability of warfarin-sodium inclusion complexes formed with permethylated monoamino-β-cyclodextrin (original) (raw)

“…Both 3DGM (HP-βCD/DPU = 1/1) and 3DGM (HP-βCD/DPU = 2/1) showed cross-peaks between H-A (7.32 ppm) and H-B (7.11 ppm) of DPU and H-6 (3.78 ppm) in the βCD cavity (Figures and S2). Notably, NOESY NMR spectroscopy can be used to identify the protons involved in the inclusion complex of the guest molecule and CD based on cross-peaks . The H-3 and H-6 protons of CD are located at the wide and narrow ring edges of CD, respectively .…”

Section: Resultsmentioning

“…Notably, NOESY NMR spectroscopy can be used to identify the protons involved in the inclusion complex of the guest molecule and CD based on cross-peaks. 35 The H-3 and H-6 protons of CD are located at the wide and narrow ring edges of CD, respectively. 36 Tachikawa et al reported that 1 H– 1 H NOESY NMR spectroscopic results showed that S-allyl cysteine in garlic forms a cross-peak with H-6 of CD, revealing an inclusion mode.…”

Section: Resultsmentioning

“…The inclusion complexes between PMMABCD and warfarin were investigated using CE coupled to NMR spectroscopy in aqueous solution [31]. The reversal in elution order was observed at varied pH values.…”

Section: Monocationic and Dual-cationic Cds As Chiral Additivesmentioning

“…21 In contrast, an NMR study of an inclusion complex between Warfarin and b-cyclodextrin was interpreted as R-and S-Warfarin binding in the anionic open-chain form (Figure 1). 22 Other experimental studies involving a combination of NMR, absorption spectroscopy and fluorescence spectroscopy have suggested the simultaneous presence of multiple different tautomers in alternative environments making any interpretation of the available data challenging. [23][24] Some structural data on Warfarin bound to different biological targets is also available.…”

Section: Introductionmentioning