Repolarization reserve determines drug responses in human pluripotent stem cell derived cardiomyocytes (original) (raw)

“…A better approach is where a cell expressing many types of ion channels is used to more accurately assess all potential interactions. One group, using MEA, tested the effects of eleven reference compounds on electrical activity of iPSC-CMs [89]. Of these, 5 were hERG blockers, 2 were Ca 2+ channel blockers, 1 was a nonselective Ca 2+ channel/hERG blocker, 1 was a K ATP -channel blocker, and 2 were I Ks blockers.…”