Ecological analysis of antigen-specific CTL repertoires defines the relationship between naïve and immune T-cell populations (original) (raw)

“…Although we have previously shown selective expansion of T cells from the naive into the immune repertoire (17,28), the data in this study suggest that this selection favors high-avidity T cells. Intriguingly, the proportion of high-avidity cells in both the naive and immune populations for all of the epitope specificities analyzed reflected the immunodominance hierarchy observed postinfection, with NP 366 -and PA 224 -specific populations containing significantly more high-avidity cells than the PB1-F2 62 or NS2 114 populations (p , 0.001).…”

Section: Prevalence Of High-avidity T Cells Is a Determinant Of Respocontrasting