What we can and cannot tell about the wiring of the human brain (original) (raw)

“…dMRI and tractography methods can be also used to extract connection patterns and probe functional boundaries. 4,9 This has been shown with controlled studies for a large number of regions in the cortex and subcortex (for instance References [41][42][43][44] ; see also Section 3.2). However, current limitations in structural connectome estimation, as we explore throughout this review, can limit the accuracy, interpretability and generalizability of such approaches for node delineation.…”

Section: Limitations and Open Problemsmentioning

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“…dMRI and tractography methods can be also used to extract connection patterns and probe functional boundaries. 4,9 This has been shown with controlled studies for a large number of regions in the cortex and subcortex (for instance References [41][42][43][44] ; see also Section 3.2). However, current limitations in structural connectome estimation, as we explore throughout this review, can limit the accuracy, interpretability and generalizability of such approaches for node delineation.…”

Section: Limitations and Open Problemsmentioning

“…46 Here, we briefly review some of these considerations. *Extrinsic 4,9 connections that traverse white matter include local U-fibers (up to~30 mm in length) connecting neighboring regions and long-range fascicles connecting remote regions within or between hemispheres. Intrinsic connections are horizontal and intra-cortical (<3 mm in length).…”

Section: Limitations and Open Problemsmentioning

“…White matter is highly relevant to ageing: later-life cognitive decline may partly be caused by 'cortical disconnection', a microstructural deterioration of the brain's connective pathways through processes such as axonal demyelination that reduces information transfer efficiency [1][2][3] . The concept of disconnection has in large part been supported by analyses of diffusion MRI (dMRI); a non-invasive, quantitative method that exploits the Brownian motion of water molecules, allowing inferences to be made about the underlying microstructure of brain white matter in vivo [4][5][6] .…”

Section: Introductionmentioning

“…White matter is highly relevant to ageing: later-life cognitive decline may partly be caused by cortical disconnection, a microstructural deterioration of the brain's connective pathways through processes such as axonal demyelination that reduces information transfer efficiency123. The concept of disconnection has in large part been supported by analyses of diffusion magnetic resonance imaging (dMRI), a non-invasive, quantitative method that exploits the Brownian motion of water molecules, allowing inferences to be made about the underlying microstructure of brain white matter in vivo 456.…”

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