Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles (original) (raw)

“…The regular spacing between hair follicles is an example of periodic patterning and has been attributed to a reaction-diffusion mechanism in the epidermis (Huh et al, 2013;Nagorcka, 1983;Nagorcka and Mooney, 1985). Simulations show qualitative similarities between reaction-diffusion models and a final 'spotted' pattern of hair follicles, although, as we have argued in this article, this type of observation is not unique to a reactiondiffusion mechanism (see Fig.…”

Section: Hair Follicle Patterningmentioning

“…Recently, it has been demonstrated that Fgf20 knockout mice do not show dermal condensation, which is required for hair follicle formation, and thus the defect results in the loss of guard hair (Huh et al, 2013). Furthermore, it has been reported that the Scaleless chicken mutant, which lacks feathers and limb scales, harbours a nonsense mutation in the Fgf20 gene (Wells et al, 2012).…”

Section: Discussionmentioning

“…Condensation of dermal fibroblasts follows the occurence of placode formation. In condensation; synthesis of Fibroblast Growth Factor (FGF) gene synthesized from placodes and first stages of development of hair follicle is completed and this enables the dermal papillae to condensate (13). Besides it is thought that Fibroblast Growth Factor Receptor (FGFR1) gene may be one of initiator factors of the hair morphogenesis (6).…”

Section: Effective Genes On Hair Follicle Growthmentioning