Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer (original) (raw)

“…34,45 Here, our data reveal for the first time that expansion of circulating and tumor-infiltrating MDSC populations in NPC patients is positively correlated with the levels of COX-2 in tumor tissues (P < 0.001). COX-2 derives bioactive PGs, particularly PGE2, which is one of the main proinflammatory factors.…”

Section: Discussionmentioning

See 3 more Smart Citations

“…34,45 Here, our data reveal for the first time that expansion of circulating and tumor-infiltrating MDSC populations in NPC patients is positively correlated with the levels of COX-2 in tumor tissues (P < 0.001). COX-2 derives bioactive PGs, particularly PGE2, which is one of the main proinflammatory factors.…”

Section: Discussionmentioning

“…Many studies have reported that COX-2 expression is usually upregulated in human cancers, including NPC. 34,44,45 COX-2 activity is detected throughout the progression of a premalignant lesion to a metastatic phenotype. Increased expression of COX-2 is associated with angiogenesis, decreased host immunity, enhanced invasion and metastasis in cancers.…”

Section: Discussionmentioning

See 2 more Smart Citations

“…IDO is also produced by MDSCs, regulatory dendritic cells and TAMs [6,52,125,126]. Silencing of IDO within the tumor using Salmonella typhimurium as a tumor-homing vector to deliver a short-hairpin RNA targeting IDO, allowed tumor infiltration of activated ROS-producing neutrophils and consequent tumor cell death [127].…”

Section: Other Immunosuppressive Moleculesmentioning